aplastic anemias chapter 19 objectives + review questions

bone marrow failure is

the reduction or cessation of blood cell production affecting one or more cell lines

common finding of aplastic anemia

pancytopenia

aplastic anemia severity based on

bone marrow hypocellularity, neutophil count, platelet count

fanconi anemia

inherited chromosomal instability

most common inherited aplastic anemia

FA

dyskeratosis congenita is

short telomers on chromosomes

schwachman bodian diamond syndrome (SBDS) is characterized by

decreased pancreatic enzyme secretion

chronic kidney disease is characterized by

decrease EPO secretion from kidneys

pure red cell aplasia is

disorder of RBC production

the clinical consequences of pancytopenia include

fatigue, infection, & bleeding

idiopathic acquired aplastic anemia is due to a(n)

unknown cause

the pathophysiology mechanism of acquired idiosyncratic aplastic anemia is

destruction of stem cells by autoimmune T cells

the most consistent blood findings in severe aplastic anemia are

macrocytosis, thrombocytopenia, & neutropenia

the treatment that has shown the best success rate in young patients with severe aplastic anemia is

bone marrow transplant with an HLA-identical sibling

mutations in genes that code for the telomerase complex may induce bone marrow failure by causing

premature death of hematopoietic stem cells

the primary pathophysiologic mechanism of anemia associated with CKD is

inadequate production of EPO