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Ch. 5 - 8
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What are the functions of the skeletal system?
Functions of the Skeletal System
Support
Storage of minerals (95% calcium stored in the bones)
Blood cell production (bone marrow)
Leverage (muscles contract to pull on bone)
Protection (skull protect brain)
What is the structure (or matrix) of bone?
Matrix of Bone:
Calcium hydroxide + calcium phosphate = hydroxyapatite crystals
Hydroxyapatite crystals resist compression
2/3 of the matrix is collagen which gives bone tensile strength
Bones can break w/ enough force, but collagen fibers prevent it from shattering
Hydroxyapatite crystals + Collagen makes bone tissue extremely strong
What is the difference between compact bone & spongy bone?
1) Compact Bone (outer)
Compact bone is all hard, solid matrix called Lamellae
2) Spongy Bone (inner) - aka Trabeculae bone
Spongy bone has these struts that go in different directions called trabeculae - allows bone to withstand pressure from different directions
Define compact bone.
Compact Bone is all hard, solid matrix called Lamellae.
3 rings of Lamellae fit in to create an Osteon
In the center of each osteon there is a space called central canal - that holds blood vessels and is an important source of O2 and nutrients for the cells in the bone
Perpendicular to central canals - there are perforating canals - blood vessels
Explain the lamellae of compact bone.
Lamellae = concentric (central)
3 layers of Lamellae
each lamellae has collagen fibers going in different directions - this gives some flexibility to bone
In compact bone, you have concentric lamellae called Osteons.
Between the Osteons, there’s more lamellae called interstitial lamellae
All around the bone - circumferential lamellae
What does the structure of bone (Osteon) consist of? What is the function of central canal? Canaliculi? Lacunae? Osteocytes?
Osteon:
Lamellae - matrix
Central canal - holds blood vessels
Canaliculi - from central canal to osteocytes, canaliculi are tiny canals that travel from lacunae to lacunae, to get to the osteocytes in each lacunae - this allows the passage of oxygen and nutrients for mature bone cells
Osteocytes - mature bone cells
Lacunae - houses osteocytes
What are the 4 types of cells in bone tissue?
Osteoblasts
Osteocytes
Osteoclasts
Osteoprogenitor cells
What are osteoblasts?
Osteoblasts
found on the inner & outer surfaces of bone
make bone by laying down osteoid (unmineralized - no calcium or phosphate)
when osteoid becomes mineralized, then it becomes the matrix of bone
an osteogenic cell (means forming bone) → osteogenesis (process of forming bone)
… When osteoblasts stop secreting the matrix and trap themselves in that matrix/lacuna — they lose their function of secreting more matrix — therefore they become mature Osteocytes.
What are osteocytes?
Osteocytes = mature bone cells
function: maintain the protein and mineral content of the matrix
if osteocytes die, bone will break down
What are osteoclasts?
Osteoclasts
secrete HCI and enzymes to breakdown calcium, phosphate, & collagen
leads to osteolysis
lysis = breakdwon
we only want this to happen when blood calcium is low - since calcium is stored in the bone, it removes calcium from bone and put it in our blood
What are osteoprogenitor cells?
Osteoprogenitor cells → osteoblasts
found on inner & outer surfaces of bones
stem cells that differentiated to form new osteoblasts
osteoblasts are important in laying down osteoid, which can become mineralized and give rise to the matrix of bone)
heavily involved in the repair after a fracture (osteogenesis)
What are the 2 bone membranes? Explain.
Bone Membranes
Periosteum
outer surface of the bone
isolates & protects the bone from surrounding tissue
actively participates in bone growth & repair
periosteum has 2 layers:
inner layer: osteoprogenitor cells, osteoblasts, osteoclasts
outer layer: made of dense irregular connective tissue; it holds the bone to muscle
attached
Endosteum
inner surface of bone (covers spongy bone/trabecular)
lines the medullary cavity, incomplete
consists of osteoprogenitor cells
actively involved in repair & growth
peri = around
endo = within
How is the periosteum anchored & attached to the bone?
Sharpey’s fibers (perforating fibers): collagen fibers
periosteum has an outer layer:
outer layer: made of dense irregular connective tissue; it holds the bone to muscle
What is epiphysis, diaphysis, & metaphysis?
Epiphysis: ends of long bones
Diaphysis: shaft of long bones
Metaphysis: narrow growth zone between epiphysis & diaphysis
Define the shapes of bones: long bones, short bones, pneumatized bones, suture bones, flat bones, irregular bones, sesamoid bones.
Long bones: longer than wider
Short bones: look irregularly boxy
Pneumatized bones: air cells to make the bone lighter (pneumo = air)
Suture bones: small bones found within suture lines
Flat bones: spongey bone, sandwiched between 2 plates of compact bone
Irregular bones: complex shapes
Sesamoid bones: formed within tendons - the only one we have is the patella
What are the 2 types of ossification (bone growth)?
Ossification = bone growth
Intramembranous ossification
only head, face, clavicle
begins at 6 weeks
Endochondral Ossification
all other bones in the body formed thru this process
involved in the development of limbs, vertebrae, & hips
formed initially as cartilage, then formed into bone
Define intramembranous ossification.
Intramembranous ossification
Flat bones of the head, face, & clavicle
This process begins w/ mesenchymal cells
Mesenchyme = embryonic tissue & gives rise to all kinds of CT
mesenchymal cells are cells of mesenchyme - which are going to start differentiating (specialized cells)
as soon as angiogenesis (blood vessel formation) secure around mesenchymal cells, they differentiate into osteoblasts - which create matrix
spicules grow into one another - keeps growing and builds osteoid around blood vessels until it creates spongey bone
Define endochondral ossification. What are the 2 parts to bone growth?
Endochondral ossification
all other bones in the body formed thru this process
the developing bone begins as cartilage cells
cartilage matrix grows inward (grows in length) → interstitial growth
cartilage matrix grows outward (grow thick) → appositional growth
Endochondral Ossification: Interstitial Growth
Endochondral Ossification: Interstitial Growth (grow longer)
occur at around 8 weeks of development
continues due to hormonal influence until early adulthood the growth stops
cartilage wants to be a bone - it has chondrocytes inside and the membrane is pericardium
once angiogenesis begins and blood vessels start coming in, the perichondrium is going to become periosteum
periosteum contains osteoblasts - starts secreting osteoids, as they secrete osteoid they lay down a thin collar of bone around the diaphysis (shaft of bone)
when this bone collar is created, the chondrocytes in the shaft are being deprived of oxygen and start dying - and start leaving small cavities
the blood vessels start piercing and move in - taking some of those osteogenic cells from the periosteum in w/ them - which they start laying down spongey bone (built from osteogenic cells)
Primary ossification center: in the region of diaphysis
then some things occur at the epiphysis (ends of long bone)
blood vessels go in and take in osteogenic cells - start making spongey bone
Secondary ossification center: formed at epiphysis
metaphysis: nothing happens - we save that cartilage its our growth plate
we lay down more bone and bone elongates - continues until done growing
when fully grown, its called Epiphysial Line (no longer spongey bone)
Endochondral Ossification: Appositional Growth
Endochondral Ossification: Appositional Growth (grows in girth, thicker)
enlarging the diameter of bone
blood vessels that run parallel to the bone becomes surrounded by bone cells
“tunnels” begin to form
each tunnel had a blood vessel in it
Explain bone maintenance, remodeling & repair.
Injury & repair
when a bone is broken, bleeding occurs (bone is highly vascular)
a network of spongey bone forms
osteoblasts are overly activated, thus resulting in enlarged callused area
this area is now stronger and thicker than normal bone
How does a fracture repair itself?
Repair of a Fracture
blood vessels are severed at the fracture - tear in the periosteum
bleeding leads to hematoma (blood clot) which closes off the site of injury, blood cells in the area die off - tissue becomes swollen & painful
phagocytic cells start cleaning up that area and lay down a soft callus
new bone & collagen fibers laid down by osteogenic cells, fibroblasts from periosteum, and endosteum - stabilized bone
What are the 5 types of fractures?
5 Types of Fractures
Transverse fracture: break is across the shaft - transverse axis of bone
Displaced fracture: not aligned, sharp edges pierce into soft tissue
Compression fracture: more common in vertebrae - looks compressed
Colles’ fracture: distal radius - lateral forearm bone
Spiral fracture: twisting force applied to bone
What is achondroplasia?
Achondroplasia (genetic disorder - Dwawrfism)
A = without
Chondro = cartilage
a congenital condition involving defective growth of cartilage and defective endochondral ossification (process of bone formation in all other bones of body)
(normal head, small body)
What is osteoporosis? Which bone cells are responsible for osteoporosis?
Osteoporosis
Bone becomes porous, loses mass & often leads to fractures
Which bone cells are responsible for osteoporosis?
Osteoclasts are responsible for osteoporosis
But bone remodels to stress, so if you put stress on your bone, they will build more bones
What bones are in the axial skeleton?
Axial Skeleton (80 bones)
Skull & associated bones
Cranium
Face
Auditory ossicles
Hyoid
Thoracic cage
Sternum
Ribs
Vertebral column
Vertebrae
Sacrum
Coccyx
What is the top half of the head called?
Top Half of Head = Calvarium
if you remove the calvarium, you can see the cranial floor
notice 3 fossa (depression)
anterior cranial fossa
middle cranial fossa
posterior cranial fossa: cerebellum
What are the 8 cranial bones of the skull?
Cranial Bones:
Frontal bone
Parietal bones (2)
Temporal bones (2)
Occipital bone
Sphenoid bone
Ethmoid bone
What are the 14 facial bones of the skull?
14 Facial Bones
Unpaired bones (2):
Mandible
Vomer: forms inferior part of nasal septum
Paired bones (12)
Maxillae: forms upper jaw
Palatine bones: 2 L-shaped bones that lie posterior to the maxillae
Nasal bones: 2 rectangular bones join medially to form bridge of the nose
Inferior nasal conchae
Lacrimal bones: really small, anterior to ethmoid bone - located on medial wall of orbits, lacrimal = tears
Zygomatic bones
Besides the nasal bone, what’s the rest of the nose made of?
Hyaline cartilage
What bone is not part of the skull but associated with it? What is its function?
Hyoid bone
U-shaped & just inferior to the mandible (high up in neck)
Function: to anchor the deep muscles of the tongue
unique bc its the only bone in body that doesn’t articulate w/ any other bone
Greater cornu & lesser cornu (horn)
What are the 3 ear ossicles in order from lateral to medial? Where are they found?
3 Ear Ossicles
found within petrous portion of temporal bone
MIS
Malleus
Ineus
Stapes
The Vertebral Column (Spinal Column)
The Vertebral Column (Spinal Column)
flexible, curve S-shaped structure
the main support for the body axis
protects spinal cord, provides attachment sites for ribs & for muscles of neck & back
in fetus & infant, it consists of 33 bones at birth but inferiorly, 9 of those bones fuse to form the sacrum & coccyx
end up with a total of 26 bones adult
What is in between vertebrae?
In between veterbrae, we have fibrocartilage, intervertebral discs that help w/ cushioning & separating vertebrae
What are the parts of the vertebrae?
7 Cervical vertebrae
12 Thoracic vertebrae
5 Lumbar vertebrae
Sacrum (5 fused vertebrae)
Coccyx (4 fused vertebrae)
What are the primary curvatures of the spine?
Primary Curvatures
Thoracic & Sacral
What are the secondary curvatures of the spine?
Secondary Curvatures
cervical & lumbar
What is the function of the transverse foramina of cervical spine?
transverse foramina: all allow blood vessels to pass through
Define bifid appearance.
Bifid appearance
spinous process of C2 appears to be splitting almost like a wishbone
Everywhere we have articulation w/ another bone, we have ________.
Everywhere we have articulation w/ another bone, we have hyaline cartilage.
What are the components of the general vertebra?
General Vertebra
Body: flat, intervertebral disc found between bodies - anterior = body
Spinous process (posterior): when you touch your back and feel bumps
Transverse process: project laterally (each side)
Lamina: connects the spinous & transverse process (2)
Pedicle “little feet”: connects transverse process to vertebral body
Vertebral arch: inner rim of both lamina and both pedicle
the opening is called Vertebral foramen
this is where the spinal cord is found & protected by the vertebral foramen
Intervertebral foramen
What are the characteristics of the Cervical Vertebra : Atlas/C1
Cervical Vertebra : Atlas/C1
basically holding the head
no vertebral body, kinda looks like a ring
transverse process: projects laterally
no spinous process
anterior & posterior tubercle found on anterior & posterior arch
transverse foramina
facet for dens
superior articular facet
forms a joint which helps to nod “yes”
slight depressed, occipital condyles fit here to allow for rocking head
What are the characteristics of the Cervical Vertebra : Axis/C2
Cervical Vertebra : Axis/C2
has a body, spinous process, & other typical vertebral processes
transverse processes are much shorter
Odontoid process (aka Dens): on the anterior & surface, on vertebral body, acts like a pivot for head rotation “no”
What is the importance of the Atlas and Axis of the cervical vertebra?
Atlas and Axis (C1 + C2)
In severe head trauma or a car crash where the head is jerked forward and back, the dens may fracture and be forced posteriorly into the brain stem
fatal → causing death
Dens (Odontoid Process): projection from vertebral body of Axis - rotation for “no”
Transverse ligament holds the Dens in place
What are the characteristics of C3 - C7 of the cervical vertebrae?
C3 - C7
Body is wider than the depth of vertebrae
Spinous process are short and bifid - except for C7
Vertebral foramen is triangular
Transverse foramen
Characteristics of Thoracic Vertebrae
Characteristics of Thoracic Vertebrae (12)
the 12 vertebrae all articulate w ribs
laterally each side of the vertebral body has 2 facets called demifacets or costal facets which articulate w/ the ribs
transverse processes have facets that articulate w the tubercles of the ribs called transverse costal facets
vertebral foramen is circular
Characteristics of Lumbar Vertebrae
Characteristics of Lumbar Vertebrae (5)
Pedicles and Lamina are shorter and thicker
spinous processes are short and flat, project out posteriorly
processes are larger to accommodate larger muscles of the back
vertebral foramen is triangular (kinda like cervical region is triangular)
provide stability, no rotation between vertebrae
Characteristics of Sacrum
Sacrum
5 fused vertebrae
curved, triangular shaped
Landmarks to know:
Base: the widest part of the sacrum at the top
superior articular process (of S1) will articulate w/ inferior articular process (of L5)
Promontory: on the anterior aspect of S1 body, the lip or edge of the base
Transverse lines: created where fusion of vertebrae took place
Ala (wings): can be seen anterior or posterior, both sides
Auricular surface: can be seen laterally
There’s more… read notebook
Coccyx - why is it important
Coccyx = “Tailbone”
3-5 fused vertebrae
small & triangular
important to anchor ligaments that help hold down your spinal cord
coccygeal cornu: projections
Explain the Thoracic Vertebrae and Rib Articulation.
Thoracic Vertebrae and Rib Articulation
Head of rib and tubercle of rib articulate w/ the vertebra
Ribs have two ends:
the anterior end attaches to costal cartilage, which connects rib to sternal end
vertebral end (more rounded shape, head of rib), as you move away from the head it tapers in a little called the neck of rib, then tubercle of the rib, then the rib angles, the rest is the body
Why is the costal groove important? Why is costal cartilage important?
(costal = ribs)
Costal groove: found on the inferior aspect of the ribs, important for nerves and blood vessels
Costal cartilage: connects rib to sternal end
Head of rib articulates with _____ of the thoracic vertebrae. Costal tubercle articulates w/ _________ of the thoracic. It angles, then curves anterior, then the sternum would be there, connected by ______.
Head of rib articulates with costal facet of the thoracic vertebrae. Costal tubercle articulates w/ transverse costal facet of the thoracic. It angles, then curves anterior, then the sternum would be there, connected by costal cartilage.
How many ribs are there? What are the 3 types of ribs?
Ribs (24 total)
True Ribs: ribs 1-7
each true rib has own costal cartilage - connects to sternum
False Ribs: ribs 8-12
8-10 merge w costal cartilage of true 7
Floating Ribs: ribs 11-12
very short costal cartilage that they just float & don’t connect to sternum
Landmarks:
Body or shaft w/ angle
Costal groove: important for nerves & blood vessels, inferior view
Costal cartilage: connects rib to sternal end
What are the 3 parts to the sternum?
Sternum
Manubrium (superior)
Body (middle)
Xiphoid process (inferior)
What are fontanels? Why are they important?
Fontanels = soft spots
Anterior fontanel (closes last by age 2)
Posterior fontanel
Fontanelles are the soft spots on a baby's head where the skull bones have not yet fused, allowing for the head to mold during birth and for the brain to grow rapidly in infancy
Importance: age 0-2 our brains haven’t finished growing yet, we need to pass through the birth canal. That’s why we need to have these soft spots.
What’s the different between scoliosis and kyphosis?
Scoliosis: abnormal curvature of spine
Kyphosis: exaggerated rounding of the T-spine (C shape)
What is the pectoral girdle?
Pectoral Girdle
upper part of body
Clavicle & Scapula
because only the clavicle attaches to the axial skeleton, the scapula can move around quite freely across the thorax
What is the importance of the shallow socket of scapula?
Shallow socket of scapula
scapula articulates with humerus — where the humerus fits into the scapula, there’s a shallow socket — this allows for great range of motion
What are the 2 ends of the clavicle?
Clavicle has 2 ends:
Sternal end - more blunt, straight
Acromial end - more rounded, articulates w the acromion on the scapula
What is the largest and longest bone of the arm?
Humerus
What is the difference between
Coronoid fossa
Coracoid process
Conoid process
Coronoid fossa - humerus
Coracoid process - scapula
Conoid process - clavicle
What is the difference between the radius & ulna?
Ulna - medial bone of forearm
Radius - lateral bone of forearm
When we say “funny bone”, what are we actually talking about?
Ulnar nerves: passes between the medial epicondyle & olecranon process
if you hit this part of elbow, it elicits numbness or tingling sensations down to the pinky - “funny bone”
What are the 3 regions of hand? How many are there
Carpals (8)
Metacarpals (5)
Phalanges (14)
#1 thumb → #5 pinky
Define carpals. Name the two rows and bones in each row.
Carpals (16 total)
gliding movements between bones making the wrist flexible
(in order from lateral to medial)
Row 1: Proximal Carpal Bones
Scaphoid
Lunate
Triquetrum
Pisiform
Row 2: Distal Carpal Bones
Trapezium
Trapezoid
Capitate
Hamate (hook on anterior)
What is retinaculum? What is its function?
Retinaculum - fibrous connective tissue, goes from scaphoid to pisiform
function: hold down structures that pass from forearm down to hand
How many phalanges do you have on one side?
14 phalanges per side
What is the total # of phalanges in the upper extremities?
28 total phalanges in upper extremitites
In metacarpals, where is the head, shaft, and base?
Metacarpals
Head = distal end
Shaft = middle
Base = proximal end
What is the Pelvic Girdle? What does it do?
Pelvic Girdle - Hip Bones or 2 Coxal Bones (aka os coxae)
“Hip girdle” attaches lower limbs to spine & supports the viscera (organs) in the pelvis
weight of the body passes through this girdle to lower limbs
articulates w the sacrum
Anteriorly, the two hip bones unite, held together by fibrocartilage called:
Pubic symphysis - connection of both pubic bones
Name the 3 parts of Coxal Bone (hip).
Coxal bone
ilium (largest)
pubis (anterior)
ischium (inferior)
What is the acetabulum?
Where all 3 parts of the Coxal bone fuse together at their shallow, depressed regions to create a deep socket called Acetabulum.
What organ rests upon the pubis?
Bladder rests on pubis.
What’s the difference between the true (lesser) pelvis and the false (greater) pelvis?
True pelvis - urinary bladder and reproductive organs found
False pelvis - digestive organs found
Female vs Male Pelvis
Female Pelvis:
inlet larger
oval shaped
pubic angle > 100
Male Pelvis:
inlet smaller
heart shaped
pubic angle 90 or <
What is the largest, longest, & strongest bone in the body?
Femur - thigh bone
How can we tell anterior vs posterior in the Femur?
Posterior in Femur: can see linea aspara - not visible on anterior view
Linea aspara at proximal end looks like its split - can see a few lines - Y
Lateral aspect: gluteal tuberosity
Medial aspect: pectineal line
What 2 bones articulate to make up the knee joint?
Knee joint: femur articulates with tibia
fibula has nothing to do w knee joint
What is between the Tibia and Fibula? (hint: it’s also between the ulna & radius)
Interosseous membrane
what are the 3 regions of the foot? how many bones in each region?
Foot:
Tarsus (7)
Metatarsus (5)
Phalanges (14)
Name the tarsal bones. What is the largest tarsal bone?
Tarsal bones (7)
Calcaneous
Talus
Navicular
Cuboid
Cruciforms:
Medial
Intermediate
Lateral
Calcaneous - largest tarsal bone
function of talus? creates stability & balance + holds a lot of weight
talus articulates w 4 bones
What are joints?
Joints: connections between bones that may or may not permit movement
Two bones may be in direct contact w/ each other or separated by:
Two bones may be in direct contact w/ each other or separated by:
Fibrous tissue
Cartilage
Fluid
Joints can be classified by either ____ or ____.
Joints can be classified by either function or structure.
What are the 3 ways joints can be classified based on their range of motion - function?
Classification of Joints: Function (ROM)
Synarthrosis : immovable joints
Amphiarthrosis : slightly moveable
Diarthrosis : freely moveable
What is synarthosis? Give a few examples of it.
Classification of Joints:
Synarthrosis - very strong but immovable joint
Ex:
Sutures (no movement)
Gomphosis (joint between teeth and jaw bones)
Synchondrosis (joint within epiphysis of bone)
binds the diaphysis to the epiphysis
Synostosis (joint between two fused bones)
What is Amphiarthrosis? Give a few examples of it.
Classification of Joints:
Amphiarthrosis - strong but slightly moveable joint
Ex:
Syndesmosis (ligaments that connect two bones but limit their motion)
between radius and ulna → distal radio-ulnar joint
between tibia and fibula → distal tibiofibular joint
Symphysis
bones are seperated by a wedge or pad of cartilage
remember pubic symphysis?
What is diarthrosis? Give a few examples of it.
Classification of Joints:
Diarthrosis - weak but freely moveable joint - greatest range of motion!
also called Synovial joints
ex: shoulder, elbox, hip, knee joints
What are the classification of joints based on structure?
Classification of Joints: based on structure
Bony fusion (fusion of frontal bones) - no ROM
Fibrous joint (skull sutures) - no ROM
Cartilaginous joint (pubic symphysis and intervertebral disc)
Synovial joint (ball & socket joints, hinge joints, shoulder, elbow, hip, knee joints)
What are synovial joints? What is the function of synovial fluid?
Synovial joints: most freely moveable joints in the body
Richly supplied by sensory nerves and has a rich blood supply
Function of Synovial Fluid:
lubricates the surfaces of the articular cartilages (aka hyaline cartilage) and reduces friction
nourishes chondrocytes
shock absorber
What is the joint cavity?
Joint cavity: contains synovial fluid
every time there is movement of this joint, the chondrocytes that are in articular cartilage are actually getting pumped nutrients and oxygen into the chondrocytes
What are the accessory structures of synovial joints?
Accessory Structures of Synovial Joints
Menisci (meniscus) - knee joints
Ligaments - all joints
Tendons - most synovial joints
Bursae sac (a fluid filled sac) - filled w synovial fluid
Tendon sheath - (an elongated bursa that wraps around a tendon)
What is the meniscus and its function?
Meniscus - made of fibrocartilage
Function: absorb the load that it receives from body, distributes evenly, provides stability
What is the strongest synovial joint in the body?
The knee joint.
The fibular collateral ligament goes from ___ to ___ and provides ____ stability.
The fibular collateral ligament goes from femur to fibula and provides internal stability.
The tibial collateral ligament is on the ____ side and provides ____ stability.
The tibial collateral ligament is on the medial side and provides medial stability.
Tendon sheath
Tendon sheath
like a blanket filled with synovial fluid that protects tendons from friction between other tendons
What two ligaments cross one another in the meniscus?
Anterior cruciate ligament
Posterior cruciate ligament
X
What are the classifications of synovial joints?
Classifications of Synovial Joints
Plane joints: gliding joints
Pivot joints: rotate & pivot only (ex: axis)
Saddle joints:
Hinge joints: trochlea fits into trochlear notch
Condylar joints: wrist, knuckles, toes
Ball and socket joints: glenohumeral joint