Immuno/Coag MediaLab Questions

Warfarin-based (coumarin derivative) oral anti-coagulant therapy is commonly monitored with :

A PTT

PT/INR

APTT and PT

Thrombin time

PT/INR

A patient's coagulation mixing study results are shown below after an initially prolonged aPTT result.

Has the aPTT been corrected by the mix? Is a factor deficiency or a coagulation inhibitor the more likely cause of the patient's prolonged aPTT?

Corrected, Factor Deficiency

Corrected, Coagulation Inhibitor

Not Corrected, Factor Deficiency

Not Corrected, Coagulation Inhibitor

Not Corrected, Coagulation Inhibitor

The causative agent of infectious mononucleosis attaches to a receptor on which of the following cells?

T helper cell

B lymphocyte

T suppressor cell

NK cell

B lymphocyte

Which of the following tests is used to monitor therapy with unfractionated heparin?

Prothrombin time (PT)

Activated partial thromboplastin time (aPTT)

Fibrinogen assay

Platelet function assay

Activated partial thromboplastin time (aPTT)

All of the following characteristics describe T lymphocytes EXCEPT?

CD4 & CD8 positive

Production of surface immunoglobulins

Production of cytokines and chemokines

Recruitment of inflammatory cells to site of inflammation or infection

Production of surface immunoglobulins

Plasmin is known to degrade Factors Va, VIIIa, and GPIb. What other substance is it known to digest?

Fibrin

Thrombin

Plasminogen

Hageman Factor

Fibrin

What is the ultimate goal of secondary hemostasis?

Formation of a platelet plug

Production of coagulation factors

Formation of a fibrin clot

Dissolution of the fibrin clot

Formation of a fibrin clot

Which of the following best describes the benefits of the RPR or VDRL tests:

Diagnostic of active syphilis

Diagnostic of latent syphilis

Diagnostic of neuro-syphilis

Monitoring course of treatment

Monitoring course of treatment

When a Specked Nuclear Antibody (ANA) pattern is observed, what follow-up test for antibodies related to Systemic Lupus Erythematosus (SLE) is not beneficial?

Testing for antibodies to Smith (Sm)

Testing for all antibodies to the extractable nuclear antigens (ENA)

Testing for antibodies to SS-A/SS-B+

Testing for antibodies to U1RNP+ and dcSSc

Testing for antibodies to U1RNP+ and dcSSc

A patient has a history of repeated spontaneous abortion. Coagulation studies reveal an elevated APTT, normal P T, normal platelet function, and normal thrombin time. Schistocytes were seen on the peripheral blood smear. Which test should be performed to determine if the patient has lupus anticoagulant?

Factor VIII assay

Mixing studies with factor-deficient plasmas

Antinuclear antibody test

Platelet neutralization test

Platelet neutralization test

Which laboratory assay is a highly specific indicator and the most sensitive assay for a diagnosis of rheumatoid arthritis?

Cyclic citrullinated peptide

Sensitized sheep cells

Latex particle agglutination

C-Reactive Protein agglutination

Cyclic citrullinated peptide

Which of the following may be seen in a CSF sample of a patient that has a subarachnoid (intracranial) hemorrhage (SAH)?

Macrophages containing hemosiderin

Uneven distribution of blood in CSF tubes collected

Clot is present in the CSF sample

Supernatant of CSF sample does not have xanthochromia

Macrophages containing hemosiderin

The type of hypersensitivity reaction associated with macrophage activation, cytokine-mediated inflammation is:

Type I Anaphylactic (Immediate hypersensitivity)

Type II Cytotoxic (Antibody mediated and antibody dependent, complement mediated

hypersensitivity)

Type Ill Immune complex mediated hypersensitivity

Type IV Cell mediated hypersensitivity (T-cell dependent)

Type IV Cell mediated hypersensitivity (T-cell dependent)

All of the following are likely the causes of an abnormal thrombin time (TT) EXCEPT:

Fibrin split products

Heparin

Aspirin

Dysfibrinogenemia

Aspirin

A prothrombin time (P T) specimen was collected at an outpatient clinic and will not be picked up by the testing laboratory's courier until several hours later. How should the specimen be stored until it is picked up by the courier?

The specimen should be centrifuged right away and stored in the refrigerator at 40 C until is

picked up the the courier.

The specimen should be frozen immediately and kept there until is tested.

The tube should remain unopened and be kept at room temperature (20-25 C).

The specimen should be protected from light.

The tube should remain unopened and be kept at room temperature (20-25 C).