general transcription factors
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7 Terms
What is the role of TFIID?
Contains TBP - the TATA binding protein, TBP binds the TATA box in the promoter DNA and bends and starts to unwind DNA
What is the role of TFIIA?
Stabilises the interaction between TBP and TATA box
What is the role if TFIIB?
Bridges TFIID and RNA polymerase, bends DNA to facilitate preinitaiton complex formation
What is the role of TFIIF?
Brings in RNA polymerase 2 to the promoter and stabilises the binding interaction
What is the role of TFIIE?
Recruits TFIIH
What is the role of TFIIH?
It has helicase activity to unwind promoter DNA
It has kinase activity, this allows phosphorylation of the C terminal domain of RNA polymerase 2, allowing elongation to occur
Describe the formation of the preinitation complex
TFIID binds the promoter through the TBP-TATA box interaction
TFIIA stabilises the TBP-TATA box interaction
TFIIB binds and bridges TFIID and polymerase 2
TFIIF brings in RNA polymerase 2
TFIIE joins the complex and recruits TFIIH
TFIIH binds. It has helicase activity and uses this to unwind DNA. It also has kinase activity, it phosphorylates the C terminal domain of the RNA polymerse, causing elongation to begin
Note 
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