general transcription factors

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7 Terms

1
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What is the role of TFIID?

Contains TBP - the TATA binding protein, TBP binds the TATA box in the promoter DNA and bends and starts to unwind DNA

2
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What is the role of TFIIA?

Stabilises the interaction between TBP and TATA box

3
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What is the role if TFIIB?

Bridges TFIID and RNA polymerase, bends DNA to facilitate preinitaiton complex formation

4
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What is the role of TFIIF?

Brings in RNA polymerase 2 to the promoter and stabilises the binding interaction

5
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What is the role of TFIIE?

Recruits TFIIH

6
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What is the role of TFIIH?

It has helicase activity to unwind promoter DNA

It has kinase activity, this allows phosphorylation of the C terminal domain of RNA polymerase 2, allowing elongation to occur

7
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Describe the formation of the preinitation complex

TFIID binds the promoter through the TBP-TATA box interaction

TFIIA stabilises the TBP-TATA box interaction

TFIIB binds and bridges TFIID and polymerase 2

TFIIF brings in RNA polymerase 2

TFIIE joins the complex and recruits TFIIH

TFIIH binds. It has helicase activity and uses this to unwind DNA. It also has kinase activity, it phosphorylates the C terminal domain of the RNA polymerse, causing elongation to begin