PHAR101A Introduction: Dosage Computation and Legal Control of Drugs

Dosage Computation Formula

Dosage = (D x W) / C

Concentration

active ingredient + excipient + carrier + binder

10 mg/ml

Drug concentration equivalent of 1% w/v

10 mg/g

Drug concentration equivalent of 1% w/w

10 ml/liter

Drug concentration equivalent of 1% v/v

10 mg/ml

1% concentration

100 mg/ml

1o% concentration

200 mg/ml

20% concentration

27 ml

Compute for the total amount of 10% (w/v) concentration tetracycline HCl, to be injected to a 210 lbs steer, if the dose is 9.5 mg/kg bw sid (once a day) for 3 days.

1.75 tab

Compute for the total amount of 100 mg calcium tablet to be given to a 15 lbs bitch, if the dose is 26 mg/kg bw daily for 1 month. COMPUTE FOR 1 DAY.

52.5 tabs

Compute for the total amount of 100 mg calcium tablet to be given to a 15 lbs bitch, if the dose is 26 mg/kg bw daily for 1 month. COMPUTE FOR 1 MONTH.

1 ppm

1 mg/kg

1 ppm

1 g/ton

250 g/ton

How much penicillin is needed by 1 ton of feed, if the inclusion rate is 250 ppm?

8 tons

How many tons of feed can be medicated by 1 kg of josamycin, if the inclusion rate is 125 ppm?

How to change % to ppm

move the decimal point 4 places to the right

How to change ug/dl to ppm

Change dl to L, add 1 digit THEN Change ug to mg, move the decimal point 3 places to the left

100 ppm

convert 0.01% to ppm

0.8 ppm

convert 80 ug/dl to ppm

2.24 ml

Compute for vincristine sulfate to be injected to a 44 lbs, if the dose is 0.75 mg/m2 once a week for 2 months. Available drug in the market is 2 mg/ml vial. CHECK ANTINEOPLASTIC CHART.

Stock Solution Formula

Formula: Quantity wanted x % wanted / % at hand

1,333.33 ml

Prepare a 1 gal of 10% formaldehyde from 30% stock solution. COMPUTE FOR ml of formalin.

2, 666.67 ml

Prepare a 1 gal of 10% formaldehyde from 30% stock solution. COMPUTE FOR ml of water.

Legal Controls of Drugs

Registration under FDA and BAI + Requirements are LTO and CPR

Certificate of Product Registration

CPR stands for

License to Operate

LTO stands for

Bureau of Animal Industry

BAI stands for

Food and Drug Administrations

FDA stands for

Manufacturing

Studies on efficacy, adverse effect, contraindications, interactions, and withdrawal period

Good manufacturing practices

GMP stands for

Primary Packaging

shall mean any material including printed material, employed in the packaging of product, excluding any outer packaging used for transportation or shipment, that is in direct contact with the electronic cigarette refill solution.

Secondary Packaging

shall mean any material including printed material, employed in the packaging of product, excluding any outer packaging used for transportation or shipment, that is not in direct contact with the electronic cigarette refill solution (e.g. product inserts, tags, etc.).

Over The Counter drugs

OTC stands for

Prescription Drug

Rx stands for

Yellow Prescription Drugs

S2 stands for

S2 license

license for doctor that will prescribe narcotics/controlled substances

S3 license

license for pharmacist

S4 license

license for drug supplier

Generic Act of 1988

rules for vets to follow when writing prescription

Class I

Classification of Controlled Substances for drugs that have a high potential for abuse. No medical uses for treatment.

Class I

Classification of this Controlled Substances: Ecstasy, heroin, LSD, marijuana, PCP

Class II

Classification of Controlled Substances for drugs that have High potential for abuse. Has accepted medical use for treatment with HIGH physical and HIGH psychological abuse potential.

Class III

Classification of Controlled Substances for drugs that have less potential for abuse. Has accepted medical use for treatment with LOW physical and HIGH psychological abuse potential.

Class IV

Classification of Controlled Substances for drugs that have lesspotential for abuse. Has accepted medical use for treatment with LOW physical and LOW psychological abuse potential.

Class V

Classification of Controlled Substances for drugs that have lesspotential for abuse. Has accepted medical use for treatment with LOW physical and LOW psychological abuse potential like cough medicines with Codeine

Class II

Classification of this Controlled Substances: Morphine, oxycodone, methamphetamine

Class III

Classification of this Controlled Substances: Anabolic steroids, hydrocodone

Class IV

Classification of this Controlled Substances: Vallum, Xanex, Darvon, Phentermine

extra label use of drug

ELUD stands for

22. 4691 or 22.5 or 23 tons

How many tons of feeds can be medicated with 2 pails of 10 lbs apramycin, if the inclusion rate is 405 ppm?