Mon (040125) Charts, Analogies, Mnemonics

0.0(0)
studied byStudied by 16 people
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
Card Sorting

1/56

flashcard set

Earn XP

Description and Tags

Intro to hemostasis, primary hemostasis, secondary hemostasis, quality assurance, fibrinolytic systems.

Study Analytics
Name
Mastery
Learn
Test
Matching
Spaced

No study sessions yet.

57 Terms

1
New cards

Analogy of Hemostasis:

  • Roads =

  • Road Surface =

  • Traffic Flow =

  • Potholes =

  • Calling 311 to have pothole filled =

  • Construction workings patching potholes =

  • Asphalt pressing device =

  • Roads = Blood Vessels

  • Road Surface = Endothelium

  • Traffic Flow = Blood Flow

  • Potholes = Vascular Damage Injury

  • Calling 311 to have pothole filled = Chronic Signaling

  • Construction workings patching potholes = Platelets

  • Asphalt pressing device = Coag Factors

2
New cards

Stages of Hemostasis

  1. Primary Hemostasis

  2. Secondary Hemostasis

  3. Fibrinolysis

<ol><li><p>Primary Hemostasis</p></li><li><p>Secondary Hemostasis</p></li><li><p>Fibrinolysis</p></li></ol><p></p>
3
New cards

Primary Hemostasis

Platelet plug formation at site of vascular injury

4
New cards

Secondary Hemostasis

Enzymatic Activation of Coagulation Factors to stabilize the platelet plug - Fibrin / Fibrinogen

5
New cards

Fibrinolysis

Gradual Dissolving of Clot and initiation of vascular healing

6
New cards

Ligands:Platelet Receptor(s)

  • vWF:GPb/IX/V

  • Collagen:GPIa/IIa;GPVI

  • Fibrinogen: GPIIb/IIIa

  • ADP:P2Y1 and P2Y12

  • Thrombin: PAR1 and PAR4

7
New cards

What are the Platelet Receptor(s) for vWF?

GP1b / IX / V

8
New cards

What are the Platelet Receptor(s) for Collagen?

GPIa / IIa; GPVI

9
New cards

What are the Platelet Receptor(s) for Fibrinogen?

GPIIb / IIIa

10
New cards

What are the Platelet Receptor(s) for ADP?

P2Y1 and P2Y12

11
New cards

What are the Platelet Receptor(s) for Thrombin?

PAR1 and PAR4

12
New cards

Coagulation Factors

Includes: I-XIII (except VI), HK & HMWK, and PK

<p>Includes: I-XIII (except VI), HK &amp; HMWK, and PK</p>
13
New cards

Factor I Common Name

Fibrinogen

14
New cards

Factor II Common Name

Prothrombin

15
New cards

Factor III Common Name

Tissue Factor, Tissue Thromboplastin

16
New cards

Factor IV Common Name

Calcium

17
New cards

Factor V Common Name

Labile factor, Proaccelerin

18
New cards

Factor VII Common Name

Stable factor, Proconvertin

19
New cards

Factor VIII Common Name

Antihemophilic factor

20
New cards

Factor IX Common Name

Christmas factor, Plasma thromboplastin component

21
New cards

Factor X Common Name

Stuart factor, Stuart-Prower factor

22
New cards

Factor XI Common Name

Plasma thromboplastin antecedent

23
New cards

Factor XII Common Name

Hageman factor

24
New cards

Factor XIII Common Name

Fibrin-stabilizing factor

25
New cards

Factor HK, HMWK Common Name

High-Molecular-Weight Kininogen, Fitzgerald factor

26
New cards

Factor PK Common Name

Prekallikrein; Fletcher factor

27
New cards

Classification of Coagulation Factors: Functional Groupings

  • Substrate: Fibrinogen

  • Cofactor: V, VIII, & HMWK/HK

  • Enzymes:

    • Serine Proteases: IIa, VIIa, IXa, XIa, XIIa, PK

    • Transaminase: XIIIa

28
New cards

Classification of Coagulation Factors: Structural (Physical) Groupings

  • Contact Group: XII, XI, HMWK/HK, PK

  • Prothrombin Group: II, VII, IX, X, Protein C & S

  • Fibrinogen Group: I, V, VIII, XIII

29
New cards

Which Structural Group(s) are NOT consumed during clotting?

Contact group and Prothrombin group (EXCEPT FII)

30
New cards

Which Structural Group(s) are consumed during clotting?

Fibrinogen group and FII of the prothrombin group

31
New cards

Which Structural Group(s) are Vitamin K DEPENDENT?

Prothrombin group

32
New cards

Contact Group Factors

XII, XI, HMWK, PK

33
New cards

Prothrombin Group

II, VII, IX, X, Protein C & S

34
New cards

Fibrinogen Group Factors

I, V, VIII, XIII

35
New cards

Clotting Factor Mnemonic

Foolish People Try Climbing Long Slopes After Christmas Some People Have Fallen

<p><strong><span style="color: red">F</span></strong>oolish <strong><span style="color: red">P</span></strong>eople <strong><span style="color: red">T</span></strong>ry <strong><span style="color: red">C</span></strong>limbing<span style="color: red"> </span><strong><span style="color: red">L</span></strong>ong <strong><span style="color: red">S</span></strong>lopes <strong><span style="color: red">A</span></strong>fter <strong><span style="color: red">C</span></strong>hristmas <strong><span style="color: red">S</span></strong>ome <strong><span style="color: red">P</span></strong>eople <strong><span style="color: red">H</span></strong>ave<strong> <span style="color: red">F</span></strong>allen</p>
36
New cards

Foolish People Try Climbing Long Slopes After Christmas Some People Have Fallen

Fibrinogen (I), Prothrombin (II), Tissue Factor (III), Calcium (IV), Labile Factor (V), Stable Factor (VII), Antihemophilic Factor (VIII), Christmas Factor (IX), Stuart-Prower Factor (X), Plasma Thromboplastin (XI), Hageman Factor (XII), Fibrin Stabilizing Factor (XIII)

<p><strong>F</strong>ibrinogen (I), <strong>P</strong>rothrombin (II), <strong>T</strong>issue Factor (III), <strong>C</strong>alcium (IV), <strong>L</strong>abile Factor (V), <strong>S</strong>table <strong>F</strong>actor (VII), <strong>A</strong>ntihemophilic Factor (VIII), <strong>C</strong>hristmas Factor (IX), <strong>S</strong>tuart-Prower Factor (X), <strong>P</strong>lasma Thromboplastin (XI), <strong>H</strong>ageman Factor (XII),<strong> F</strong>ibrin Stabilizing Factor (XIII)</p>
37
New cards

“Foolish” corresponds to which clotting factor?

Fibrinogen (I)

38
New cards

“People” corresponds to which clotting factor?

Prothrombin (II)

39
New cards

“Try” corresponds to which clotting factor?

Tissue Factor (III)

40
New cards

“Climbing” corresponds to which clotting factor?

Calcium (IV)

41
New cards

“Long” corresponds to which clotting factor?

Labile (V)

42
New cards

“Slopes” corresponds to which clotting factor?

Stable Factor (VII)

43
New cards

“After” corresponds to which clotting factor?

Antihemophilic (VIII)

44
New cards

“Christmas” corresponds to which clotting factor?

Christmas (IX)

45
New cards

“Some” corresponds to which clotting factor?

Stuart-Prower (X)

46
New cards

“People” corresponds to which clotting factor?

Plasma Thromboplastin Antecedent (XI)

47
New cards

“Have” corresponds to which clotting factor?

Hageman Factor (XII)

48
New cards

“Fallen” corresponds to which clotting factor?

Fibrin-stabilizing (XIII)

49
New cards

Intrinsic, Common, and Extrinsic Memory Chart

  • Intrinsic: TENE = 12, 11, 9, 8

  • Common: $$ = 10 → 5 → 2 → 1

  • Extrinsic: = 3+7

<ul><li><p>Intrinsic: TENE = 12, 11, 9, 8</p></li><li><p>Common: $$ = 10 → 5 → 2 → 1</p></li><li><p>Extrinsic: = 3+7</p></li></ul><p></p>
50
New cards

Intrinsic Pathway Clotting Factors

XII, XI, IX, VIII

51
New cards

Common Pathway Clotting Factors

X, V, II, I

52
New cards

Extrinsic Pathway Clotting Factors

VII, III

53
New cards

Pre-Analytical Tests: Specimen Stability

  • PT

  • PTT (non-heparinized)

  • PTT (heparinized)

  • Fibrinogen

  • D-Dimer

  • Unfractionated Heparin & LMWH

<ul><li><p>PT</p></li><li><p>PTT (non-heparinized)</p></li><li><p>PTT (heparinized)</p></li><li><p>Fibrinogen</p></li><li><p>D-Dimer</p></li><li><p>Unfractionated Heparin &amp; LMWH</p></li></ul><p></p>
54
New cards

Which Pre-Analytical Tests is NOT stable for only four hours? How long is it stable for?

Prothrombin Time (PT) is stable for 24 hrs

55
New cards

Which Pre-Analytical Test must be centrifuged? When must it be tested?

PTT (Heparinized) must be centrifuged 1 hour after collection and tested within 4 hours of collection

56
New cards

What temperature is required for Pre-Analytical Test Specimen Stability

Room temperature

57
New cards

Which Pre-Analytical Tests are stabile for four hours?

  • PTT (non-heparinized)

  • PTT (heparinized)

  • Fibrinogen

  • D-Dimer

  • Unfractionated Heparin & LMWH