Antimigraine Agents (Triptans)

What is the prototype?

Sumatriptan

• Given PO, SQ, or intranasal

Why is it prescribed?

Acute migraine abortive medication

How does it work?

Vasoconstriction of cranial vessels

What happens if it works too well?

• Sedation is the main effect (i.e., CNS)

• Effects related to vasoconstriction may also occur, like dizziness, weakness, blood pressure alterations, visual disturbances (i.e., not hallucinations), and chest pain/angina

What is special about it (4)?

• Caution

  • Geriatric clients (i.e., underlying vascular disease)

  • Clients with CAD risk factors r/t vasoconstriction

  • Lactation

  • Renal/hepatic dysfunction

• CI with MAOIs are possible

  • Must wait at least 2 weeks after discontinuation

• Extreme caution with ergot-containing drugs (i.e., another migraine tx) b/c it may increase vasoconstrictive effects

• Monitor BP, kidney/liver function, migraine severity, dizziness, sedation, and falls