[MEDORG-LEC-SEMIS-01-PT1] PARASYMPATHETIC VS SYMPATHETIC DRUGS

THIS FLASHCARDS IS ABOUT [MEDORG] CHOLINOMIMETICS-ANTICHOLINERGICS

Cholinomimetics

Parasympathetic Agonists is also known as?

Acetylcholine

What is the Prototype Structure of Parasympathetic Agonists (Cholinomimetics)?

Muscarinic/Nicotinic

What is the Primary Receptors of Parasympathetic Agonists (Cholinomimetics)?

Quaternary ammonium

What is the Nitrogen Type of Parasympathetic Agonists (Cholinomimetics)?

Poor if quaternary

What is the CNS Penetration of Parasympathetic Agonists (Cholinomimetics)?

Small

What is the Molecular Size of Parasympathetic Agonists (Cholinomimetics)?

Flexible Molecules

What is the Flexibility of Parasympathetic Agonists (Cholinomimetics)?

Usually absent

What is the Aromatic Rings of Parasympathetic Agonists (Cholinomimetics)?

Essential

What is the Ester Group Role of Parasympathetic Agonists (Cholinomimetics)?

Minimal Role

What is the Hydroxyl Groups Role of Parasympathetic Agonists (Cholinomimetics)?

Low

What is the Lipophilicity of Parasympathetic Agonists (Cholinomimetics)?

Poor (quaternary)

What is the BBB Crossing Ability of Parasympathetic Agonists (Cholinomimetics)?

Short unless modified

What is the Duration of Action of Parasympathetic Agonists (Cholinomimetics)?

Anticholinergics

Parasympathetic Antagonists is also known as?

Atropine

What is the Prototype Structure of Parasympathetic Antagonists (Anticholinergics)?

Muscarinic (mainly)

What is the Primary Receptors of Parasympathetic Antagonists (Anticholinergics)?

Usually tertiary amine

What is the Nitrogen Type of Parasympathetic Antagonists (Anticholinergics)?

Good if tertiary

What is the CNS Penetration of Parasympathetic Antagonists (Anticholinergics)?

Bulky

What is the Molecular Size of Parasympathetic Antagonists (Anticholinergics)?

Rigid bulky molecules

What is the Flexibility of Parasympathetic Antagonists (Anticholinergics)?

Present (often two rings)

What is the Aromatic Rings of Parasympathetic Antagonists (Anticholinergics)?

Present in some

What is the Ester Group Role of Parasympathetic Antagonists (Anticholinergics)?

Minimal Role

What is the Hydroxyl Groups Role of Parasympathetic Antagonists (Anticholinergics)?

Moderate-High

What is the Lipophilicity of Parasympathetic Antagonists (Anticholinergics)?

Possible (tertiary)

What is the BBB Crossing Ability of Parasympathetic Antagonists (Anticholinergics)?

Longer

What is the Duration of Action of Parasympathetic Antagonists (Anticholinergics)?