Unit 12 immunosuppressant agents and chemotherapy

Basic principles of immunosuppressive therapy

Steroids

dexamethasone

Prednisone

methylprednisolone

Basic principles of immunosuppressive therapy

Anti-rejection / immunosuppression agents

mycophenolate mofetil

cyclosporine

tacrolimus

muromonab-CD3 (reversal agent AND prevention of ongoing rejection)

Immunity

Active

diphtheria, tetanus, pertussis vaccine

flu vaccine

meningococcal vaccine

Immunity

Passive

Antivenin

digoxin immune Fab

Rho(D) immunoglobulin

Cancer

Angiogenesis inhibitor

bevacizumab

Cancer

Antimetabolites - CCS

methotrexate

Cancer

Mitotic inhibitors - CCS

paclitaxel

Cancer

Topoisomerase inhibitors - CCS

topotecan

Cancer

Alkylating agents - CCNS

cisplatin

Cancer

Cytotoxic antibiotics - CCNS

doxorubicin

Cancer

Management of side effects

allergic response: diphenhydramine

inflammatory response: dexamethasone

N&V: ondansetron

renal damage, bone marrow suppression