Catabolism AA+urea cycle

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Medicine

Last updated 10:53 AM on 11/11/22
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8 Terms

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How to form ammoniac(NH3)
oxidative deamination+transamination
2
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How to get rid of ammoniac
Ammoniagenesis(15%)+ureogenesis(85%)
3
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Causes increase urea
Hypercatabolism proteins+nephropathy
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Causes increase ammoniac
Liver failure+Iatrogenic+Alcool poisoning
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OCT deficiency
stops step 2=metabolism citrulline → acute decompensation neuro-hepato-digestive
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AA only ketogenesis
L+K
L+K
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AA ketogenesis+Gluconeogenesis
W+I+F+Y
W+I+F+Y
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4 steps of ureogenesis and where
Ammoniac→CarbomoylP by CSP-1 (Mitochondria)

CP+Ornithine→citrulline by OCT (Mitochondria)

Citrulline+Aspartate→Arginosuccinate by AS (Cytosol by tORNT)

Arginosuccinate→Arginine+fumarate by AL (Cytosol)

Arginine→urea+ornithine by arginase
Ammoniac→CarbomoylP by CSP-1 (Mitochondria) CP+Ornithine→citrulline by OCT (Mitochondria) Citrulline+Aspartate→Arginosuccinate by AS (Cytosol by tORNT) Arginosuccinate→Arginine+fumarate by AL (Cytosol) Arginine→urea+ornithine by arginase