Catabolism AA+urea cycle

How to form ammoniac(NH3)::oxidative deamination+transamination

How to get rid of ammoniac::Ammoniagenesis(15%)+ureogenesis(85%)

4 steps of ureogenesis

1. Ammoniac→==CarbomoylP== by @@CSP-1@@ (Mitochondria)
2. CP+$Ornithine$→==citrulline== by @@OCT@@ (Mitochondria)
3. Citrulline+^^Aspartate^^→==Arginosuccinate== by @@AS@@ (Cytosol by tORNT)
4. Arginosuccinate→==Arginine==+^^fumarate^^ by @@AL@@ (Cytosol)
5. Arginine→==urea==+$ornithine$ by @@arginase@@

==Urea cycle== uses 3ATP but %%Krebs cycle%% produces 3ATP→neutral

Causes increase urea:: Hypercatabolism proteins+nephropathy

Causes increase ammoniac:+ Liver failure+Iatrogenic+Alcool poisoning

OCT deficiency:: stops step 2=metabolism citrulline → acute decompensation neuro-hepato-digestive

AA only ketogenesis:: L+K

AA ketogenesis+Gluconeogenesis:: W+I+F+Y