AIDS? Incomplete

what is aids

syndrome characterized by a weakened immune system

Aids reduces

ability to fight infection and certain cancers

AIDS is caused by

HIV (Human Immunodeficiency virus)

immune system kicks in when

body detects non-self cell

how the body notices non-self cells

if they lack the class 1 protein

B cells

derived and mature in bone marrow

t cells

derived from bone marrow, mature in thymus

what consists of lymphocytes

b and t cells

t-helper/t4 cell function

alerts immune system to antigen presence and coordinate immune response

HIV virus binds to cell receptor and fuses into cells then it

uncoats and reverse transcription occurs and t4 cell is infected with HIV

Once T4 cell is infected what happens

translation of viral RNA and assembly occurs of HIV

4 ways to stop HIV

fusion inhibitors and reverse transcriptase inhibitors. and integrase inhibitors and protease inhibitors

the virus needs both...

CD4 receptor and CCR5 receptor

people immune to HIV and AIDS is missing

CCR5 receptor

Calophyllum lanigerum is a tree that

gets to 21 meters and is found in Peat swam forest in Sarawak.

NCI collected samples and analyzed Calophyllum lanigerum and isolated....

eight compounds

Calanolide A has...

anti-HIV-1 activity which inhibits reverse transcriptase and when used in a cocktail it can extend life of AIDS patient

Where is Calanolide A found

twigs and sticks from Calophyllum lanigerum

Researchers went back to original Calophyllum lanigerum tree and found...

it was gone and other trees didn't have the compound

Luckily Singapore...

had a botanic garden with Calanolide A compound

Ancistrodcladus korupensis