Cure Your Fatigue Ch 1-3
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39 Terms
What is fatigue according to Morley Robbins?
lack of cellular energy production, not simply a lack of sleep or motivation
Where does all energy in the body originate?
From energy produced inside the mitochondria of cells
What is ATP?
Adenosine triphosphate, the molecule that stores and transfers cellular energy.
Why does Robbins say fatigue is misunderstood?
Because it is treated as a symptom instead of a metabolic dysfunction.
What body system is central to energy production?
The metabolic system, especially mitochondrial function
What is oxidative stress?
An imbalance between free radicals and antioxidants that damages cells.
Why is oxidative stress important in fatigue?
Excess oxidative stress impairs mitochondria and reduces ATP production.
What is fatigue at the cellular level?
Reduced ATP availability
Where is ATP primarily produced?
Mitochondria
What metabolic process produced ATP aerobically?
Oxidative phosphorylation
What inputs are required for oxidative phosphorylation?
Electrons, oxygen, enzymes, minerals
Why are calories insufficient for energy?
They require enzymatic conversion to ATP
What happens when ETC efficiency drops?
ATP synthesis decreases
Why does ETC inefficiency occur?
Oxidative stress and enzyme dysfunction
How does oxidative stress affect metabolism?
It down regulates ATP production
What is irons physiological role?
Oxygen transport via hemoglobin
Is iron directly involved in ATP synthesis?
No
What happens to unbound iron?
It catalyzes oxidative reactions
What is functional iron overload?
Iron excess despite normal serum markers
Why does tissue iron accumulation impair energy?
It increases mitochondrial oxidative damage
What mineral regulates iron redox state?
Copper
Why is copper required for iron metabolism?
It activates iron-oxidizing enzymes
What is ceruloplasmin?
A copper dependent ferroxidase
What does ceruloplasmin convert!
Fe2+ to Fe3+
Why is Fe3+ important?
It binds safely to transferrin.
What happens when ceruloplasmin is low?
Iron becomes redox-active.
Why can iron supplementation increase fatigue?
It raises oxidative stress
When is iron most harmful?
When copper-dependent regulation is impaired
What is the body’s primary iron source?
Recycled iron
Where does iron recycling occur?
Macrophages and liver
What do enzymes require to function?
Mineral cofactors
What I the biologically active form of ATP?
Mg-ATP
Why is magnesium required for ATP?
It stabilizes ATPs phosphate bonds.
What happens when magnesium is deficient?
ATP cannot be efficiently used
Why does stress deplete magnesium?
Increased urinary and cellular loss
How does stress affect metabolism?
Increases ROS (reactive oxygen species) and mineral loss.
What is inflammation metabolically?
An energy conserving state
How does inflammation alter mitochondrial output?
Suppresses ATP synthesis
Note 
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