Exam 1: Antipsychotics and Antidepressants

Serotonin and Dopamine Receptors

5HT and DA

3 Ring Drugs similar to TCA

Phenothiazines

Low potency Phenothiazine action

Sedation

High potency Phenothiazine action

More EP effects

Phenothiazines block what receptors? leads to what?

Many, motor EP Problems

Non-Phenothiazine antipsychotics target what receptor mainly?

D2 dopamine

Atypical Antipsychotics block what receptors?

5HT and D2

Benefit of Atypical Antipsychotics and why it is used front line? What can it negatively effect?

fewer EP motor effects, hyperglycemia

Typical Antipsychotics

Chlorpromazine and Haloperidol

Atypical Antipsychotics

Clozapine and Risperidol

Risperidol Side effect

Heart arthymia

Clozapine Side Effect

low WBC

4 Classes of Antidepressants and acronym

TCA, SSRI, SNRI, MAOI This shit sucks man

Antidepressant Type: Imipramine

TCA

Antidepressant Type: Amitriptyline

TCA

Antidepressant Type: Fluoxetine (Prozac, Sarafem)

SSRI

Antidepressant Type: Sertraline (Zoloft)

SSRI

Antidepressant Type: Venlafaxine (Effexor)

S/NRI

Antidepressant Type: Duloxetine (Cymbalta)

S/NRI

Antidepressant Type: Phenelzine

MAOI

Antidepressant Type: Selegiline (Emsam)

MAOI

TCA antidepressant block what receptors?

NE and 5HT

Most Dangerous side effect of TCAs?

Cardiac toxicity

SSRI Mechanism

Selective Serotonin Re-uptake by blocking SERT, leaves more Serotonin in synapse

Sertraline (zoloft) blocks uptake of what?

Serotonin and Dopamine

S/NRI differences Vs SSRI

Serotonin and Norepinephrine

MAOI stands for

Monoamine Oxidase Inhibitor

What does MAO do?

Degrade 5HT Serotonin

MAOI bind reversibly or Irreversibly?

Irreversibly

Problem with MAOIs

Negative Drug Drug interactions

Pro of Transdermal Selegiline (Emsam)?

Lower risk of hypertensive crisis