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Mutation
A change in DNA base sequence
Point Mutations
Chemical changes in one base pair of a gene
Silent
Point mutation that results in a new codon but codes for the same amino acid
Missense
Point mutation that results in a new codon and amino acid
Sickle Cell Anemia
Missense mutation
Nonsense
Point mutation that results in a stop codon that prematurely ends the sequence
Insertion
Mutation that inserts a codon(s)
Deletion
Mutation that deletes a codon(s)
Inframe
Insertion/deletion mutation that inserts/deletes an entire codon (multiples of 3)
Frameshift
Insertion/deletion mutation that inserts/deletes not in multiples of 3