Katzung Chapter 16 Histamine, Serotonin and the Ergot Alkaloids

Dimenhydrinate

First generation antihistamine, used for motion sickness

Diphenhydramine

First generation antihistamine, cold/allergy products and sedative in OTC sleep aid products

Hydroxizine

First generation antihistamine, anti-allergy product with marked sedation

Meclizine

First generation antihistamine, used for motion sickness, less sedation

Promethazine

First generation antihistamine, antiemetic

Chlorpheniramine

First generation antihistamine, cold/allergy products

Fexofenadine

Second generation antihistamine, anti-allergy product

Loratadine

Second generation antihistamine, anti-allergy product

Cetirizine

Second generation antihistamine, anti-allergy product

Sumatriptan

5HT1D/1B receptor agonists used for migraines

Almotriptan

5HT1D/1B receptor agonists used for migraines

Rizatriptan

5HT1D/1B receptor agonists used for migraines

Zolmitriptan

5HT1D/1B receptor agonists used for migraines

Eletriptan

5HT1D/1B receptor agonists used for migraines

Naratriptan

5HT1D/1B receptor agonists used for migraines

Frovatriptan

5HT1D/1B receptor agonists used for migraines

Melatonin

Food supplement promoted for sleep

Histamine

Mediator of immediate allergic and inflammatory reactions, important role in gastric acid secretions and mediator of immune function (infammation) and chemotaxis od WBCs

Serotonin

Involved in moods and diurnal sleep cycles, vasoconstrictor in the brain

Ramelteon

Melatonin agonists for insomnia

Tasimelteon

Melatonin agonists for non 24 hour sleep-wake disorder