Bone and Joint Medications

Flashcards covering key concepts from the Bone and Joint Medications lecture notes for exam preparation.

What is the main characteristic of Rheumatoid Arthritis in Stage 1?

The body mistakenly attacks its own joint tissue.

What happens during Stage 2 of Rheumatoid Arthritis?

The body makes antibodies and the joints start swelling.

What is a common deformity associated with late-stage Rheumatoid Arthritis?

Boutonniere deformity of the thumb.

What drug classification do Methotrexate and Etanercept fall under?

Disease-Modifying Antirheumatic Drugs (DMARDs).

What is the mechanism of action for Etanercept?

Inactivates tumor necrosis factor.

What are common side effects of Methotrexate and Etanercept?

Risk for infections and hepatic toxicity.

What is the primary indication for Allopurinol?

Chronic gout.

What is the mechanism of action for Allopurinol?

Decreases uric acid levels.

What dietary recommendations are important for patients taking Allopurinol?

Stay away from foods high in purine and avoid alcohol.

What is the drug classification of Raloxifene?

Selective estrogen receptor modulator.

What is the mechanism of action for Raloxifene?

Decreases bone resorption.

What are common side effects of Raloxifene?

Hot flashes and increased risk of PE/DVT.

What is a potential adverse effect of Alendronate?

Osteonecrosis of the jaw.

What is the mechanism of action for Alendronate?

Inhibits bone resorption by decreasing the number and action of osteoclasts.

What does parathyroid hormone (PTH) do?

Pulls calcium from bone and GI from food to maintain normal calcium levels.

What should be monitored when administering Calcium Citrate/Carbonate?

Calcium levels.

What is the indication for Calcitonin-Salmon?

Treat osteoporosis and hypercalcemia caused by hyperparathyroidism.

What is the mechanism of action for Calcitonin-Salmon?

Increases renal calcium excretion.