Obstructive pulmonary diseases - Asthma

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5 Terms

1
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What is Asthma? (2)

  1. A chronic inflammatory disorder of the airways

  2. There are recurrent episodes of wheezing, breathlessness, chest tightness, and coughing

2
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Types of asthma (4)

  1. Atopic

  2. Non-atopic

  3. Drug induced - aspirin

  4. Occupational asthma (Repeated exposure to different chemicals)

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Ultimate cause of atopic asthma

Hypersensitivity reaction in those with a genetic predisposition for the development of IgE antibodies against common environmental allergens

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Mechanism of an acute asthma attack Priming or sensitization (5)

  1. Allergen →

  2. Activation of TH2 cells →

  3. cytokines →

  4. Plasma cells produce produce IgE →

  5. IgE coats submucosal mast cells

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Mechanism of an acute asthma attack

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