GI Drugs

gastric acidity, antidiarrheals, laxatives

GI drug uses include control _____, _____, and _____

antacids, h2 receptor blockers, proton pump inhibitors, anticholinergics, prostaglandins, protective agents

control of gastric acidity includes (6)

base, neutralize

antacids contain a _____ (carbonate/hydroxide), _____ HCl in stomach

constipation, diarrhea, rebound

antacid problems include _____ (Al), _____ (Mg), and acid _____

histamine, gastric mucosa, HCl, h2 receptor blockers

_____ binds to h2 receptors in _____ and increases _____ secretion, _____ negate effects

h2 receptor blockers

cimetidine, famotidine, ranitidine

well tolerated, antihistamines, proton pump inhibitors, cns

h2 receptor blockers are generally _____, never called _____, not as effective as _____, no _____ effect

stomach wall, hydrogen ions, proton pump inhibitors, hydrogen ion

proton pump enzyme in _____ secretes _____, _____ destroy function reducing _____ concentration

proton pump inhibitors

esomeprazole, lansoprazole, omeprazole

effective, TI, side effects

proton pump inhibitors are very ____, high _____, few _____

HCl, protective mucus

mucosal cells secrete _____, goblet cells secrete _____

anticholinergics

pirenzepine

prostaglandins

misoprostol

protective agents

sucralfate

opioid derivatives, adsorbents, bismuth salicylate

antidiarrheals include (3)

opioid derivatives

loperamide, diphenoxylate

adsorbents

kaolin, pectin

overuse, constipation

problems with antidiarrheals are _____ and _____

water, GI tract

laxatives generally stimulate and draw _____ into _____

bulk forming, stimulants, hyperosmotic

laxatives include (3)

bulk forming

citrucel, metamucil

stimulants

correctol, ex-lax

hyperosmotics

epsom salts, MgOH

GI, overuse

laxative problems include _____ irritation and _____/dependence

participation, certain patients, education, overuse

general rehab concerns of GI drugs include enhancing _____, critical role in _____, patient _____ (avoid _____)

NSAIDs, GI, refer

pt implications of GI drugs include dealing with patients taking _____, adverse effect is _____ symptoms, _____ back to MD if recognized