antimicrobial principles

what does gram - have?

• lipopolysaccharide

• outer membrane

• peptidoglycan

• cytoplasmic membrane

what does gram + have?

• peptidoglycan

• cytoplasmic membrane

name some gram +

• staphlococcus

• enterococcus

name some gram -

paseudomonas aeruginosa

name some characteristics of cidal

• cell wall

• cell membrane

• reactive intermediates

• 2 interior target sites

• irreversible inhibition

• free radicals

name some characteristics of static

• 1 interior target site

• RNA

static ABs

• macrolides

• tetracyclines

• linezolid/tedizolid

• rifampin

what are some drugs with MRSA coverage?

1. ceftaroline *

2. glycopeptides

3. tetracyclines

4. lipopeptides

5. delafloxacin *

6. oxazolidinones

7. lincosamides

8. folate antagonists

9. gentamicin *

10. fosfomycin *

11. nitrofurantoin *

what are some drugs with pseudomonas coverage?

1. polymyxins

2. aminoglycosides

3. aztreonam *

4. fosfomycin *

5. beta-lactams

6. fluoroquinolones

what is concentration dependent?

aminoglycosides

what is time dependent?

beta lactams

what is AUC dependent?

vanc and fluoro