Microbiology basics repetition

Focal infection

Pathogen from local infection enter blood / lymph and spread

Septicemia

Pathogens multiply in blood

Virulence

Strain-specific degree of pathogenocity

Microbiota

**Types of organisms** present in certain environment

Bacteremia

Pathogens in blood

Pathogenocity

Ability of a whole species to cause infection / disease

Sepsis

**Toxic inflammatory** by spread of pathogens or products

Microbiome

Collection of organisms including its functions -metabolism, genes - in certain environment

Koch postulates

1. Organism must be present in the same region that show disease
2. Isolation & cultivation are possible
3. Injected culture cause disease with the same symptoms
4. Pathogen can be isolated & injected over and over again

Pediculosis

Pediculosis humanus capitis

Cytolytigen toxins

* Hemagglutinate red blood cells
* Pore formation *L.monocytogenes, S.aureus*
* *Cleaving components:*
* **phosphotidylcholine** *clostridum*
* **sphingomyelinase** *S.aureus*

^^Clostridioides difficile^^

Associated diarrhea, mild + pseudomembraneous colis fatal

Clostridium perfringens

perfringen diarrhea with gas