Microbiology basics repetition

Focal infection

Pathogen from local infection enter blood / lymph and spread

Septicemia

Pathogens multiply in blood

Virulence

Strain-specific degree of pathogenocity

Microbiota

**Types of organisms** present in certain environment

Bacteremia

Pathogens in blood

Pathogenocity

Ability of a whole species to cause infection / disease

Sepsis

**Toxic inflammatory** by spread of pathogens or products

Microbiome

Collection of organisms including its functions -metabolism, genes - in certain environment

Koch postulates

1. Organism must be present in the same region that show disease

2. Isolation & cultivation are possible

3. Injected culture cause disease with the same symptoms

4. Pathogen can be isolated & injected over and over again

Pediculosis

Pediculosis humanus capitis

Cytolytigen toxins

• Hemagglutinate red blood cells

• Pore formation L.monocytogenes, S.aureus

• Cleaving components:

  • phosphotidylcholine clostridum

  • sphingomyelinase S.aureus

^^Clostridioides difficile^^

Associated diarrhea, mild + pseudomembraneous colis fatal

Clostridium perfringens

perfringen diarrhea with gas