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pregnancy
highly variable even within the same couple, due dates are rarely birthdates, 3 trimesters
first trimester for mother
pregnancy test - measure HCG in urine/blood
morning sickness - can happen any time of day, good for baby
prenatal development for child
zygote (germinal)
embryo
fetus
implantation
endometrium is receptive to implantation for 4-5 days
blastocyst attaches to the endometrium via villi
blastocyst is now an embryo
trophoblast - umbilical cord, amnion, chrion, placenta, cells that contribute to birth
embryoblast > baby
zygotic phase
23-48 hours after fertilization
fertilized egg begins to divide
splitting of cells = cleavage
morula phase
zygote becomes morula (mass with many divided cells or blastomeres)
cells divide into groups (what will become baby and what will become placenta)
blastocyst phase
air bubbles appear in morula and grow to become amniotic sac
blsatocyst attaches itself to fallopian tube
“hatches” egg in uterus and attach to walls
3 stages of implantaion
apposition - adhesion of blastocyst to wall of uterus
stable adhesion - continuation of first stage to make it more secure
invasion - blastocyst buries itself in outer walls of uterus, baby begins interaction with mother’s cells
problems with implantation
genetic causes - missing genetic material, chromosomal problems
timing issues - ideal implantation time 8-9 days after ovulation
maternal causes - uterine and fallopian issues, lead to miscarriages but don’t know exact cause
endometriosis - condition where tissue from uterus moves to other parts of body, can cause clots and cysts and infertility
uterine fibroids - tumors in uterus (fibroids)
previous abortions
previous STIs
ectopic pregnancy - implantation in wrong part of body
types of fertility drugs
clomiphene - increase hormone production, triggers ovulation
gonadotropins - produce multiple ova at ovulation
other methods for pregnancy
artificial insemination - implant sample of sperm during ovulation
assisted reproduction technologies (ART) - donors
IVF - ova on petri dish with doses of sperm
gamete intrafallopian transfer (GIFT) - sperm injected into fallopian tubes
ICSI - sperm injected into ovum, places in uterus
assisted hatching - increase chances blastocyst will attach to endometrial wall
multiple births
nonidentical multiples (fraternal) - separate ova and sperm
identical multiples - single ova and sperm (monozygotic)
diamnotic and monochrionic - type of identical twins with seperate amniotic sacs but shared placenta
monoamniotic and monochorionic - rare type of identical twins, same amniotic sac and placenta
conjoined twins
placenta
allows baby and mother’s cells to not kill each other, mediator
placenta functions
lung function - absorb oxygen from mother to baby
kidney function - regulates toxins and byproducts for baby
digestive system - gives basic needs to baby
endocrine system - alters hormones from mother’s body
potential issues with placenta
placenta previa - placenta in cervix, placenta can bleed and come apart in labor
placenta abruption - premature separation from wall of utero, 1/80
umbilical cord
connects baby to placenta
parts of umbilical cord
yolk sac - outside embryo and filled with fluid that helps baby grow
allantois - collects waste
wharton’s jelly - flexible tissue that allows baby to move out of body
amniotic sac
sac filled with fluid to protect baby while giving birth, cushioning pressure, lubricant
amniotic sac problems
premature rupture - water breaking early, requires c section, induced birth
oligohydramnios - too little amniotic fluid, late pregnancies, birth defects
polyhydramnios - fluid builds up and is premature rupture that can lead to defects
gastrula
3 layers of endoderm, trimester functions
patterns of development
organogenesis
embryonic cells arrange into shield
nervulation - 1st stage, flat neural plate that forms groove, forms brain and spinal cord
nervous system development - forms parts of brain
heart development - cells clump together and form heart, heart beats faster everyday
4th week
embryo changes shape, arms begin to appear, arches for face/neck/eyebuds/earbuds
5th week
head grows to accommodate brain growth spurt, looks more human
6th week
intestines, umbilical cord, genetials, skeleton, muscles
7th week
fingers, knees, toes, ankle, organs working
8th week
brain waves begin, eyes finish developing, tail disappears
trophoblast
cells that support the baby: placenta, umbilical cord, amnion, chorion
embryoblast
cells that become baby (blastocyst becomes baby)
miscarriages
rate = 15% - 30%
percentage of miscarriages associated with chromosomal abnormality or developmental defect = 60%
ectopic pregnancies
when baby gets stuck in fallopian tube instead of uterus
the baby will not survive but an abortion (laparoscopic surgery) needs to happen to save mother
zygotic development
during the germinal period (0-14 days), the following occurs:
mitosis (cleavage)
no growth in size (blastocyst)
2 layers (1 is baby and 1 is stuff to help baby)
embryo development
During weeks 3-8, the following occurs:
differentiation in the earnest (cells specialize) into 3 layers
endoderm (inner) - internal organs
mesoderm (middle) - muscles, skeleton, blood vessels
ectoderm (outer) - nervous system, skin, teeth AND creates neural tube (brain and spinal cord)
neural tube problems
anencephaly (missing cortex) - missing part of the brain, death after birth
spina bifida (exposed spinal nerves) - spinal cord doesn’t develop
how does embryo growth occur?
cephalocaudal (head down) - develop head first then everything else
proximal distal (center outward) - inside out, inner layer first