Sympathetic Effect on Pacemaker/Cardiac Muscle Cells
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6 Terms
What is the effect of sympathetic stimulation on pacemaker cells?
promotes Na+ & Ca2+ inward movement, increasing frequent action potential and heart rate
How does sympathetic stimulation affect the pacemaker potential of pacemaker cells?
Makes the pacemaker potential shorter and faster
What happens to the drift toward threshold in pacemaker cells under sympathetic stimulation?
The drift toward threshold is quicker
How does sympathetic stimulation affect contraction in atrial and ventricular cardiomyocytes?
Increases contraction speed and strength by enhancing L-type Ca²⁺ channel activity
When the L-type Ca2+ channels (Ca2+) amplify, what happens?
Brings in more Ca2+ during the plateau phase:
More Ca2+
More CBs
More force production
How does sympathetic stimulation affect the relaxation of cardiac muscle cells?
Increases relaxation speed through enhancing the SERCA pump & preparing the heart for the next contraction
