[MEDORG-LEC-SEMIS-01-PT2] PARASYMPATHETIC VS SYMPATHETIC DRUGS

THIS FLASHCARDS IS ABOU [MEDORG] ADRENERGIC AGONISTS TO ADRENERGIC BLOCKERS

Adrenergic Agonists

Sympathetic Agonists is also known as?

Norepinephrine

What is the Prototype Structure of Sympathetic Agonists (Adrenergic Agonists)?

a and B receptors

What are the Primary Receptors of Sympathetic Agonists (Adrenergic Agonists)?

Primary or Secondary Amine

What is the Nitrogen Type of Sympathetic Agonists (Adrenergic Agonists)?

Variable

What is the CNS Penetration of Sympathetic Agonists (Adrenergic Agonists)?

Small-Moderate

What is the Molecular Size of Sympathetic Agonists (Adrenergic Agonists)?

Moderate Flexibility

What is the Flexibility of Sympathetic Agonists (Adrenergic Agonists)?

Present (Catechol Ring)

What is the Aromatic Rings of Sympathetic Agonists (Adrenergic Agonists)?

Not essential

What is the Ester Group Role of Sympathetic Agonists (Adrenergic Agonists)?

Critical for Potency

What is the Hydroxyl Groups Role of Sympathetic Agonists (Adrenergic Agonists)?

Moderate

What is the Lipophilicity of Sympathetic Agonists (Adrenergic Agonists)?

Depends on Structure

What is the BBB Crossing Ability of Sympathetic Agonists (Adrenergic Agonists)?

Short if catechol

What is the Duration of Action of Sympathetic Agonists (Adrenergic Agonists)?

Adrenergic Blockers

Sympathetic Antagonists is also known as?

Propranolol/Prazosin

What is the Prototype Structure of Sympathetic Antagonists (Adrenergic Blockers)?

a or B receptors

What is the Primary Receptors of Sympathetic Antagonists (Adrenergic Blockers)?

Secondary Amine

What is the Nitrogen Type of Sympathetic Antagonists (Adrenergic Blockers)?

Often Moderate

What is the CNS Penetration of Sympathetic Antagonists (Adrenergic Blockers)?

Larger bulky molecules

What is the Molecular Size of Sympathetic Antagonists (Adrenergic Blockers)?

More rigid structures

What is the Flexibility of Sympathetic Antagonists (Adrenergic Blockers)?

Present (bulky aromatic systems)

What is the Aromatic Rings of Sympathetic Antagonists (Adrenergic Blockers)?

Not essential

What is the Ester Group Role of Sympathetic Antagonists (Adrenergic Blockers)?

Usually absent

What is the Hydroxyl Groups Role of Sympathetic Antagonists (Adrenergic Blockers)?

Higher

What is the Lipophilicity of Sympathetic Antagonists (Adrenergic Blockers)?

Often higher than agonists

What is the BBB Crossing Ability of Sympathetic Antagonists (Adrenergic Blockers)?

Longer

What is the Duration of Action of Sympathetic Antagonists (Adrenergic Blockers)?