Drugs for IP5 Exam 3

Entecavir

Treats Hep B and HIV. MOA is inhibits base priming, inhibits reverse trasncription from pregenomic RNA, and inhibits synthesis of positive stranded HBV DNA

Tenofovir disoproxil fumarate (TDF)

Treats Hep B and HIV. Can cause nephrotoxicity so monitor for renal impairment. It is hydrolyzed in the cell.

Tenofovir alafenamide fumarate (TAF)

Treats Hep B and HIV. Phosphonodimidate appendages make drug more lipophilic, hydrolyzed in cell by carboxypeptidase liposomal cathepsin A (Cat A). Lower incidence of nephrotoxicity

Ribavirin

Used to treat Hep C. MOA is inhibits RNA polymerase. Has an ADR of hemolytic anemia

\-previr or -pravir

Used to treat Hep C. These drugs are NS3/4A protease inhibitors. They have low genetic barrier to resistance.

This drug is a NS3/4A protease inhibitor and has an ADR of photosensitivity (used to treat Hep C)

Simeprevir

Sofosbuvir

Used to treat hep C. This drug is a NS5B polymerase nucleoside inhibitor. MOA is mimics polymerase substrates and are incorporated into RNA to casue chain termination. It has high resistance barrier

\-buvir

Used to treat Hep C. What group of drugs are NS5B palm polymerase inhibitors. MOA is bind to several sites in the palm of NS5B, resulting in protein conformational change. They have a low genetic barrier to resistance

NS5B palm polymerase inhibitors

What drug class is Dasabuvir. Used to treat Hep C

\-asvir

Used to treat Hep C. These drugs are NS5A inhibitors. MOA is inhibitors act synergistically with interferons and direct acting antivirals. Do not take this drug with antacids or PPIs

NS5A inhibitor

Used to treat Hep C. What class is Ledispasvir?

Epclusa, Harvoni, Vosevi, and Mavyret

What four drugs have a black box warning for reactivation of HBV?

INSTI and two NRTIs

(BIC/TAF/FTC)

Bictegravir 50mg/Tenofovir alafenamide 25mg/ Emtricitabine 200mg

Once a day

Biktarvy

Class?

Drugs?

How to take?

INSTI and Two NRTIs

(EVG/c/TAF/FTC)

Elvitegravir 150mg/cobicistat 150mg/tenofovir alafenamide 10mg/emtricitabine 200mg

Once a day with food

Genovoya

Class?

Drugs?

How to take?

INSTIs and Two NRTIs

(EVG/c/TDF/FTC)

Elvitegravir 150mg/cobicistat 150mg/tenofovir disoproxil fumarate 300mg/emtricitabine 200mg

once a day with food

Stribild

Class?

Drugs?

How to take?

INSTI and Two NRTIs

(DTG/ABC/3TC)

Dolutegravir 50mg/abacavir 600mg/lamivudine 300mg

take once a day

Triumeq (Has same drugs for Triumeq PD just suspension form but different dosaging)

Class?

Drugs?

How to take?

INSTI and one NRTI

(DTG/3TC)

dolutegravir 50mg/lamivudine 300mg

take one a day

Dovato

Class?

Drugs?

How to take?

PI and two NRTIs

(DRV/c/TAF/FTC)

Darunavir 800mg/cobicistat 150mg/tenofovir alafenamide 10mg/emtricitabine 200mg

one a day with food

Symtuza

Class?

Drugs?

How to take?

TAF (NRTI) and NRTI

(TAF/FTC)

Tenofovir alafenamide 25mg/emtricitabine 200mg

take one a day

Descovy

TDF (NRTI) and NRTI

(TDF/FTC)

Tenofovir disproxil fumarate 300mg/emtricitabine 200mg

take one a day

Truvada

Class?

Drugs?

How to take?