hemolytic anemias (extrinsic) chapter 22 objectives + chapter questions

TTP

thrombotic thrombocytopenia purpura

HUS

hemolytic uremic syndrome

HELLP

hemolytic, elevated liver enzymes, & low platelet count

DIC

disseminated intravascular coagulation

what causes TTP

deficiency in ADAMTS-13

what can help differentiate TTP and DIC

TTP has normal coagulation test results

main cause of HUS

renal failure

characteristic of HELLP

elevated liver enzymes

characteristic of DIC

decreased platelets & fibrinogen

most common malarial infection

P. falciparum

babesiosis characteristic

tetrad forms

warm autoimmune hemolytic anemia

IgG

MAHA is characterized by

shearing of RBCs as they pass through small blood vessels

MAHA RBC morphology

schistocytes

HELLP is a serious complication of

pregnancy

which of the following is a feature found in all MAHA’s

intravascular RBC fragmentation

typical lab findings in TTP & HUS include

schistocytes & thrombocytopenia

the pathophysiology of idiopathic TTP involves

formation of platelet-VWF thrombi due to autoantibody inhibition of ADAMTS-13

which of the following tests yields results that are abnormal in DIC but are usually within reference interval or just slightly abnormal in TTP & HUS

PT & PTT

what RBC morphology is characteristically found within the first 24 hours following extensive burn injury

schistocytes & microspherocytes

which of the following test results results are abnormal in HELLP syndrome but not in DIC

aspartate aminotransferase