Biochemistry - Chapter 18 - Outline

What is the link between glycolysis and the citric acid cycle?

Pyruvate (Glycolysis) or Fatty acid degradation → acetyl CoA (Fuels the Citric acid cycle)

(Acetyl CoA) (Aerobic Cond.) Pyruvate enter where to be converted into pyruvate?

Mitochodnria

What is acetyl CoA?

Acetyl CoA is the fuel for the citric acid cycle, which processes the two-carbon acetyl unit to two molecules of CO2 while generating high-energy electrons that can be used to form ATP.

Coenzyme A (CoA or CoA-SH) is an activated carrier of what groups.

…of acyl groups such as the acetyl group.

For CoA, why is the transfer of the acyl group exergonic?

The transfer of the acyl group is exergonic because the thioester is unstable.

The pyruvate dehydrogenase complex is what type of enzyme?

A mitochondrial matrix enzyme.9

What does the pyruvate dehydrogenase complex do? Is this reaction irreversible?

It oxidatively decarboxylates pyruvate to form acetyl-CoA; the reaction is an irreversible link between glycolysis and the citric acid cycle.