Blood cell labeling, mechanisms of localization, and qc Copy

copy of Blood cell labeling, mechanisms of localization, and qc

what is plasma

liquid part of blood, clear portion with clotting factors, a dilute solution of salts glucose amino acids vitamins urea proteins and fats

what are white blood cells involved in

immune system

what are platelets involved in

blood clotting

what are red blood cells involved in

carrying oxygen

what are the two compartments of blood

plasma and cells

what serum

clear portion without clotting factors

what is the amount of blood in the body

5×10^6/mm3

T/F red blood cells are biconcave discs

true

what is the diameter of red blood cells

7-8um

what is the excess amount of red blood cells called

polycythemia

what are deficient amount of red blood cells called

anemia, macrocytic or megaloblastic, microcytic, hemolytic

how long does it take for red blood cells to synthesis in marrow

2-3 days

what is the order of red blood cell formation

stem cell (hemocytoblast) - committed cell (proerythroblast) - ribosome synthesis (early erythroblast) - hemoglobin accumulation ( lase erythroblast) -normoblast - rejection of nucleus (reticulocyte) - erythrocyte

what are the three main components that red blood cells are composed of

hemoglobin, b-12, iron

what is the job of red blood cells

carry oxygen to the body

what is the size of white blood cells

8 x 10^3/ mm3

what are megakaryocytes

platelets

what is the size of megakaryocytes/platelets

150-300K/ mm3

what are the different kinds of white blood cells

neutrophiles (62%), eosinophils (2.5%), basophils (0.5%), lymphocytes, monocytes

red blood cells, white blood cells and megakaryocytes/platelets are made were

bone marrow (myeloid tissue)

how long do red blood cells circulate in the bloodstream for

100-120 days

T/F can red blood cells twist and change shape

true

what happens when red blood cells become fragile

removed from the spleen

what does hemoglobin molecule provides binding sites for what

O2, Fe, B -12

O2 is attached to what in the hemoglobin molecule

iron

what is the gas exchange in the lungs

O2 in, CO2 out

what to do white blood cells have

nucleus

T/F does white blood cells have hemoglobin

false

how long do white blood cells live for

a few hours or days

what is the formation of lymphocytes

pluripotent stem cells - lymphoid stem cells - lymphoblast - lymphocyte

what is the formation of eosinophils

pluripotent stem cells - myeloid stem cells - eosinophilic myeloblast - eosinophils

what is the formation of basophil

pluripotent stem cells - myeloid stem cells - basophilic myeloblast - basophil

what is the formation of neutrophil

pluripotent stem cells - myeloid stem cells - neutrophilic myeloblast - neutrophil

what is the formation of monocyte

pluripotent stem cells - myeloid stem cells - monoblast - monocyte

what white blood cells are granular

eosinophil, basophil, neutrophil

what white blood cells are agranular

monocyte, lymphocytes

what is the chemotaxis movement of white blood cells

move toward sites of infection or tissue damage in response to chemical signals called chemoattractants.

what is the diapedis movement of white blood cells

squeeze through the walls of blood vessels to exit the bloodstream and migrate into tissues to fight infection or respond to injury

what can to many white blood cells lead to

leukemia AML (acute myeloid leukemia), CML (chronic myeloid leukemia), ALL (acute lymphoblastic leukemia), CLL (chronic lymphoblastic leukemia)

what can to many white blood cells lead to

agranulocytosis or leukopenia

platelets are used for what

clotting around vascular tear

platelets are created where

marrow inside a megakaryocyte

what can abnormal amounts of platelets lead to

thrombocytopenia

what is thrombocytopenia

low platelet count

what exams use Tc-99m labeled red blood cells or ultratag method

RVG cardia imaging, GI bleed studies,liver hemangiomas

what does this image show

MUGA or RVG

what does this image show

Gi bleed (accumulation outside of normal vasculature = bleed

what does this image show liver hemangioma, hot focus in liver = memangioma

what are the methods for red blood cell labeling

in- vitro, modified in vivo, in vivo

what is used for all red blood cell labeling

Tc-99m and cold pyrophosphate kit contents