MANUFACTURING PHARMACY GREEN PACOP

1. A means of administering drugs as formulated preparations is called:

a. pharmaceutical

b. drug delivery system

c. dosage forms

d. any of the above

D

2. A manufacturer who produces the products of a company without manufacturing facilities is a/ an:

a. ethical manufacturer

b. proprietary manufacturer

c. biological manufacturer

d. toll manufacturer

D

3. Primary package system as differentiated from secondary package systems:

a. are in direct contact with the product

b. have a direct effect on product shelf life

c. AOTA

d. None

C

The only true tamper resistant packaging:

a. aerosol containers

b. sealed tubes

c. breakable caps

d. shrink seals

A

Purified water that is free from pyrogen

a. purified water

b. water for injection

c. Any of the choices

d. NOTA

B

6. Viscosity enhancers are added to liquid preparations to:

a. improve pourability of products from container

b. improve palatability

c. both

d. none

C

7. The most inert grade of stainless steel used for high grade products

a. SS 304

b. SS 316

c. SS 3004

d. SS 3016

B

8. Filtration system which is recommended for handling large quantities is

a. gravimetric filtration c. pressure

b. vacuum d. cartridge filtration

C

9. Filling method which is advisable for highly viscous products

a. gravimetric filling

b. volumetric filling

c. any of the above

d. none

A

10. The advantages of emulsion over other dosage forms include:

a. increased therapeutic effects

b. increased spreading ability

c. ability to mask unpleasant odors

d. AOTA

D

11. Aggregates of powders which adhere or bond to each other to form larger particles

a. powders

b. microcapsules

c. pellets

d. granules

D

12. Storage conditions for capsules

a. 35-50% RH

b. 21-25ºC

c. AOTA

d. NOTA

C

13. Substance that "glue" powder together causing them to form granules

a. diluent

b. binder

c. lubricant

d. disintegrant

B

14. An agent that acts between surfaces in relative motion to prevent friction and wear

a. diluent

b. binder

c. lubricant

d. disintegrant

C

15. In film coating, when additives migrate to the surface, the problem is called:

a. blistering

b. wrinkling

c. sweating

d. bloom

C

16. An anteroom which separates the sterile from non sterile is a/an:

a. LAF

b. airlock

c. HEPA

d. AOTA

B

17. Area with no more than 100 particles of 0.5 micron size per cubic foot of environment:

a. Class 0.5

b. Class 500

c. Class 100

d. Class 1000

C

18. A very simple, sensitive and fast test for pyrogens using the amoebocyte of the horse shoe crab.

a. Pyrogen Test

b. LAL Test

c. Rabbit Test

d. Crab Test

B

19. Ampules are sealed by:

a. Pull sealing

b. Tip sealing

c. any of the above

d. NOTA

C

20. The period in which the product remain acceptable for use:

a. Stability

b. Shelf life

c. Accelerated Stability Studies

d. any of the above

B

21. Flow property of liquid is related to:

a. Viscosity

b. Volatility

c. Optical Property

d. Miscibility

A

22. Solubility may be enhanced through the use of:

a. Application of heat

b. Agitation

c. Reduction of particle size

d. any of the above

D

23. Dispensing equipment in the name of suspension includes:

a. Blenders

b. Impellers

c. Colloid mill

d. all of the above

D

24. A suspension may be stabilized through the use of:

a. Suspending agents

b. Hydrocolloids

c. Viscosity enhancing agents

d. AOTA

D

25. Suspensions are evaluated by:

a. Sedimentation

b. Ease of redispersability

c. Measuring of Particle size

d. Any of the above

D

26. The ff are natural emulsifying agent, except:

a. Tween 80

b. Acacia

c. Agar

d. gelatin

A

27. Water soluble abases are prepared from

a. PEG

b. sorbitol

c. Petrolatum

d. mineral oil

A

28. Polyols may be used as:

a. humectant in creams

b. viscosity contribution

c. prevent cap locking

d. AOTA

A

29. Preservatives are added to semisolid preparations to be prevent the ff except

a. decomposition

b. container

c. deterioration

d. spoilage by bacteria and molds

B

30. Mixing equipment for acid materials

a. Sigma blade mixer

b. Ribbon blender

c. Twin shell bed dryer

d. AOTA

A

31. An ideal drug delivery system (DDS) is

a. capable of controlled delivery rates

b. not highly sensitive to physiological variables

c. based on physicochemical principles

d. Any of the above

D

32. Formulation methods of achieving sustained drug release including

a. use of coating

b. embedding the drug in a matrix

c. microencapsulation

d. AOTA

D

33. Gradual sedimentation in liquid products is due to:

a. chemical reaction

b. decomposition

c. bacterial growth

d. any of the above

D

34. Filtration process wherein the liquid passes through one filter pad or disk

a. parallel

b. series

c. both a and b

d. none

A

35. A gravity operated filling set up is used for liquids which are

a. free flowing

b. foaming

c. viscous

d. either a or b

A

36. Solubility may be enhanced through

a. application of heat

b. agitation

c. reduction of particle size

d. AOTA

D

37. Suspension adjunct used to prevent the product from drying at topical application

a. sweetening agent

b. humectant

c. preservative

d. emollient

B

38. The aggregation of the dispersed globules into loose clusters within the emulsion

a. creaming

b. cracking

c. phase inversion

d. flocculation

D

39. The attire or uniform used in parenteral production include

a. cover all

b. face mask and head covers

c. boots and gloves

d. AOTA

D

40. CGMP means

a. Current Good Manufacturing Practice

b. Current General Manufacturing Program

c. Current General Manufacturing Practice

A

41. The quality of a medicinal and a related product is the sum of all factors which will contribute directly or indirectly to the products

a. safety

b. effectiveness

c. acceptability

d. AOTA

D

42. Group which is responsible for auditing the control system for evaluating product quality

a. Quality Control

b. Quality assurance

c. Production

d. Medical

B

43. The disintegration medium of plain uncoated tablet is

a. simulated gastric fluid TS

b. simulated intestinal fluid TS

c. Distilled water

d. potable water

C

44. Quality control test that are performed on granules before compression into tablets are except:

a. sieve analysis

b. bulk density

c. angle of repose

d. AOTA

C

45. The most common method of tableting active ingredients which are chemically incompatible

a. microencapsulation

b. film coating

c. add stabilizers

d. use double layer tableting

D

46. Sealing of ampule is done by

a. Pull sealing

b. softening the neck of ampule

c. Tip sealing

d. a and c

D

47. Bullet shaped capsules are called

a. spansules

b. bougies

c. pulbules

d. NOTA

C

48. This is used to increase the resistance of gas

a. Sulfur dioxide

b. Titanium Oxide

c. Ethylene oxide

d. acid

A

49. The animal of choice for in vitro rectal absorption studies

a. dog

b. pig

c. rabbit

d. mouse

A

50. Method that will produce tablets of best quality

a. direct compression

b. wet granulation

c. dry granulation

d. any of the above

B

51. Bubble test measure the efficiency of:

a. glass

b. plastics

c. membrane filter

d. air filter

C

52. A processing problem encountered only in the manufacture of tablets:

a. double impression

b. weight variation

c. molding

d. chipping

A

53. The coalescence of oil globules in a o/w emulsion is called:

a. cracking

b. inversion

c. creaming

d. sedimentation

A

54. The ff. are true for Spans, except:

a. they are resistant to addition of acids and electrolytes

b. they are hydrophobic

c. they have high HLB values

d. they from w/o emulsions

C

55. A variation of dry gum method of preparing emulsions using volatile oil is added to acacia in a bottle:

a. Oil method

b. English method

c. Emulsifier in oil method

d. Bottle method

D

56. Antioxidants which block an oxidative chain reaction in which they are not usually consumed:

a. BHT

b. EDTA

c. thiourea

d. tartaric acid

A

57. These are gas sterilants, except:

a. carbon dioxide

b. formaldehyde

c. beta propiolactone

d. sulfur dioxide

A

58. A sterilization method which destroys microorganism b y cellular protein coagulation:

a. autoclaving

b. dry heat sterilization

c. gas sterilization

d. none of the above

A

59. The usual contaminants of ophthalmic preparations are the ff., except:

a. Pseudomonas aeruginosa

b. Bacillus subtilis

c. Aspergillus fumigatus

d. Staphylococcus aureus

D

60. A commonly used capsule diluent:

a. lactose

b. starch

c. Calcium Phosphate

d. any of the above

A

61. An opacifying agent for capsules:

a. sulfur oxide

b. lactose

c. titanium oxide

d. talc

C

62. A common levigating agent:

a. glycerin

b. mineral oil

c. alcohol

d. ether

B

63. Method used for the incorporation of small amounts of potent drugs with a large amount of diluent:

a. spatulation

b. sifting

c. geometric dilution

d. levigation

C

64. The ff. excipients impart satisfactory compression characteristics to the tablet formulation except:

a. glidant

b. disintegrant

c. lubricant

d. antiadhesive

B

65. Tablet weight is determined by:

a. volumetric fill of the disc

b. pressure during compression

c. amount and nature of bunder

d. all

A

66. One part of a slightly soluble material will dissolve in ________ part of solvent

a. 10-30

b. 30-100

c. 100-1000

d. 1000-10000

C

67. Brandy and whiskey are classified as:

a. elixirs

b. spirits

c. aromatic waters

d. juice

B

68. The reduction of camphor with the aid of alcohol is called:

a. trituration

b. pulverization by intervention

c. levigation

d. any of the above

B

69. The prominently printed element on the label:

a. brand name

b. Rx symbol

c. pharmacologic category

d. generic name

B

70. A 600L paracetamol drops was manufactured. If it is packed in 60-mL bottle, the theoretical yield is:

a. 100

b. 1000

c. 10000

d. 5000

C

71. Invert sugar has the tendency to darken in color due to:

a. levulose

b. sucrose

c. glucose

d. lactose

A

72. A near saturated solution of sucrose in water:

a. simple syrup

b. syrup

c. sucrose solution

d. all

A

73. Acacia mucilage is x% dispersion in water:

a. 42

b. 35

c. 5

d. 25

B

74. Thixotropy is a characteristic demonstrated by:

a. jellies

b. magmas

c. gels

d. suppositories

C

75. Galenicals are also called:

a. extracts

b. fluidextracts

c. extractives

d. marc

C

76. The injection of large of volumes of a solution into substances tissue to provide a continuous, abundant drug supply is called:

a. hypodermicyclics

b. IV administration

c. IM administration

d. intradermal administration

A

77. Excessive use of binders in tablet affected:

a. bioavailability

b. disintegration

c. dissolution

d. all

D

78. Impart cohesive qualities to the tablet granulation:

a. diluent

b. lubricant

c. binder

d. disintegrant

C

79. Buccal tablets are intended to be dissolved:

a. swallow

b. rapidly

c. beneath the tongue

d. chewed

A

80. These are necessary components of a stable emulsion, except:

a. electrolyte

b. dispersion medium

c. dispersed phase

d. emulsifier

A

81. Problem often encountered in suspensions:

a. caking

b. smooth texture

c. slow settling

d. dispersatility

A

82. The different methods of determining the emulsion type are the ff., except:

a. Dry Gum

b. Drop dilution

c. Electrical conductivity

d. Dye

A

83. The container of choice for parenteral:

a. plastic

b. glass

c. metals

d. tubes

B

84. The container of choice for ointments:

a. jars

b. cans

c. collapsible tubes

d. widemouth bottle

C

85. Which of the ff. is not classified as a lubricant?

a. lactose

b. Stearic acid

c. Ca Stearate

d. talc

A

86. Spans & Tweens are:

a. binders

b. diluents

c. preservatives

d. surfactants

D

87. Filtration of a solution to a high degree of clarity:

a. polishing

b. dialysis

c. clarification

d. dissolution

A

88. Plastic containers are not recommended for pharmaceuticals because:

a. vapors permeate through the walls of the container

b. leeching of constituents from the plastic to the product

c. absorption of the drug molecules to the surface of the plastic

d. all of the above

e. none of the above

D

89. These are advantages of tablets, except:

a. economy

b. accuracy

c. blandness of taste

d. prolonged dissolution

D

90. HEPA filters are used for filtration of:

a. parenterals

b. ophthalmics

c. air

d. solvents

C

91. For compacting the materials in the tablet machine:

a. hopper

b. feedframe

c. dies

d. punches

D

92. Tablet granulations can be dried faster using:

a. granulator

b. oven

c. fluid bed dryer

d. solar dryer

C

93. The partial or complete separation of the top or bottom of a tablet from the main body:

a. chipping

b. capping

c. lamination

d. picking

B

94. Used for mixing powder mixtures in large volume quantity:

a. drum roller

b. V-blender

c. planetary mixer

d. compactor mills

B

95. A roller mill is used to reduce the particle size of powders in:

a. ointment

b. tablet

c. capsules

d. emulsion

A

96. This is not part of the master formula record:

a. complete batch formula

b. price per dosage unit

c. weight of each

d. description of container & closure

B

97. This part of the sugar coating process is to round off tablet contours rapidly:

a. sealing

b. subcoating

c. syruping

d. finishing

e. polishing

B

98.

Formula mg/tab batch of 600,000 tabs

Primaquine PO4 30

A. 18kg

B. 33.96kg

C. 9.96kg

D. 0.342kg

E. 0.138kg

F. 104 mg

A

99.

Formula mg/tab batch of 600,000 tabs

Lactose 56.6

A. 18kg

B. 33.96kg

C. 9.96kg

D. 0.342kg

E. 0.138kg

F. 104 mg

B

100.

Formula mg/tab batch of 600,000 tabs

Starch 16.6

A. 18kg

B. 33.96kg

C. 9.96kg

D. 0.342kg

E. 0.138kg

F. 104 mg

C