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Homeostasis
-internal conditions vary within limits
-set points change
-regulated by negative feedback
Simple Squamos
-lungs
simple cubodial
kidney tubules
-regulated transport
simple columnar
-intestines
-regulated transport
pseudostratified
respiratory tracts
aerolar
-immune system cells
-fibroblasts
-all 3 fibers
adipose
-hypodermis,breasts
-adipocytes
almost no ground substance or fibers
dense regular
-tendons
-fibroblasts
-collagen bundles
dense irregular
-fibroblasts
-collagen
-skin
reticular
-lymphocytes
-reticular fibers
blood
red/white blood cells
-ground substance is plasma
-no fibers
dendritic cells
immune system cells in skin
merkel cells
tactile sensation
sunscreen, zinc does what
reflects the uv rays
functions of integumentary system
-protection
-thermoregulation
-metabolism
-cutaneous sensation
Chemical Classes: Amino Acid Derivatives
-bind to membrane receptors
-can't be stored
-float freely
-Oxytocin and ADH
Chemical Classes: Steroids
-bind to intracellular receptors
-binded to globulins
-can't be stored
-made by er and mitochondria
-hyrdophobic
What happens in target cells?
-membrane permeability
-enzyme activity
-mitotic activity
-protein activity
-secretory activity
Hormones in Anterior Pituitary
-LH
-FSH
-ACTH
-TSH
-PRL
-GH
ADH function
-raise blood pressure
-pee less
Synthesis of TH
-throglobulin synthesis, exocytosized into colloid
-iodine brought in made into iodine
-iodine and thyroglobulin make T3 and T4
-endocyosized out of colloid
-T3T4 cleaved off diffuse across membrane
Actions of TH
-growth and development
-metabolism
-permissive hormone
Support Cells in CNS
-astrocyte
-microglia
-ependymal cells
-oligodentrites
-regulate ECM
-eat bad stuff, macrophage
-line ventricles
-make myelin sheath
Support Cells in PNS
-Schwann cells
-Satellite cells
-make myelin sheath
-similair to an astrocyte
Saltatory Conduction
myelin sheath helps action potential move faster
Chemical Synapses
NT binds to membrane
-causes local potential
-causeD by action potential
Voltage Synapse
-ions flow directly from one cell to the next through a gap junction
temoral summation
same synapse multiple times
spatial summation
different places at same time
classes of neurotransmitters
-acetocholine
-amines
-amino acids
-glutamane-excitory
-Gaba-inhibitory
-peptides
-purines
-gases
SSRI function
reuptake inhibitor
CSF
-mostly water
-similar to plasma but fewer proteins
-protect brain
-provide nutrients/eliminate waste
Choroid Plexus function
makes CSF
blood brain barrier
made of blood vessels
-provides more constant ECM
-prevents bad things from getting to brain
-tight junction between blood vessels
-astrocytes are a foot process not technically part of the bbb
Frontal Lobe
-voluntary motor output
-thinking
-remembering
-personality
Parietal Lobe
-process somatosensory info
-general senses- skin and skeletal
Occipital Lobe
visual info processing
Temporal Lobe
auditory and taste processing
-insula=taste
Brochas Area
motor area for speech, frontal lobe
Wernickes Area
understanding of speech, temporal lobe
Basal Nuclei
motivation
motor
planning
attention
Parkinsons Disease
degeneration of dopamine
basal nuclei becomes overactive
Tracts: Commisures
connect hemispheres
Tracts: Assocation
connect adjacent areas of cortex
Tracts: projection
connect cerebrum w/ lower regions
Dicephalon
-pineal gland
-hypothalamus
-thalamus
pineal gland
secretes melatonin
-light inhibits melatonin
thalamus
relay center for sensory info
hypothalamus
center for autonomic functions
Limbic System
involved with learning,emotion and memory
-dicephalon structures
-fornix
-hippocampus
-amygdala
Reticular Formation
-brain stem nuclei
-send sensory info coming into brainstem
-sends signals to thalamus
-non-specific pathways
consolidation
info going to long term memory
Declarative Memory
-thalamus
-temporal lobe
-prefrontal cortex
Procedural Memory
thalamus
-basal nuclei
-pre-motor cortex
Dorsal Horn
sensory input
Ventral horn
motor output
sensory ascending pathways
3 neuron pathway
-afferent neuron to brainstem
-brainstem to thalamus
-thalamus to primary somatosensory cortex
motor descending pathwasy
2 neuron pathway
-primary motor cortex to spinal cord
-spinal cord to muscle
roots are
sensory or motor
nerves and ramus are
motor and sensory
Nerve structure
Endonerium, perineum, epineurium
Plexus
network of nerves based on origin of nerves and where they go
Components of sensory system
-sensory input
-circuits
-perception
Perception
-perceptual détection
-magnitude estimation
-stimulus discrimation
-feature abstraction
-quality discrimination
-pattern recognition
primary sensory coding
-duration
-modality type
-strength
-location
projection pathway
specific ascending pathways
adaptation
decrease in action potential frequency in response to constant stimulus
Unencapsulated receptors in the skin
free nerve endings
hair follicle receptors
encapsulated receptors in the skin
tactile meisnners corpuscle
pacinian coruscle
receptors in joints
muscle spindles
golgi tendon organs
receptor potential is
a graded potential
analgesia
drugs that decrease pain
referred pain
convergence of 2 receptors on one ascending pathway
Salt and Sout
go through channels other receptors are membrane receptors
Gustatory Pathway
-Afferent neron cranial nerve(7,9,10)
-medulla
-thalamus
-insula
Smell Pathway
olfactory receptro(afferent neuron)
olfactory bulb
olfactory cortex
hypothalamus and limbic system
olfactory epithelium
pseudo stratified columnar
glomeruli
all neurons that detect a certain smell converge here
Hearing structure
cochlea
-endolymph fluid
-perilymph fluid
equilibrium structure
vestibule and semicircular canals
tympanic membrane
vibrates in response to air pressure
auditory tube
equalizes air pressure
membrane that the hairs hit
tectorial membrane in spinal organ corti in cochlea
sound pathway
vestibucochlear nerve
medulla midbrain
thalamus
primary auditory cortex
resonance
basilar membrane thickest at apex correlates with lower frequencies
static equilibrium
vestibule-macula are perpendicular to each other
macula saccule
macula utricle
otoliths-add density to gelatinous mass
dynamic equilibrium
cristae ampulla's
movement of fluid pushes on cupola to bend the hairs to send a signal
-signals sent to cerebellum and vestibular nuclei in brain stem
lacrimal apparatus
cleanses and lubricates the eye
prevents bacterial growth
eye layers
fibrous- sclera and cornea
vascular-iris ciliary body choroid
retina
anterior segment
aqueous humor
posterior segment
vitreous humor
helps maintain pressure
helps conduct light
iris
regulates amount of light entering eye
ciliary boy
controls the shape of the lens
accommodation
change in the shape of the lens for close up vision
close up the lens
bulges and the ciliary body constricts
myopia
near sightedness
can't see long distance
hyperopia
far sightedness
phototransduction
-light hits pigment
-2nd messenger is activated
-ion channels close
optic disk
has no photoreceptors
general senses have
Action Potentials