Development of Penicillin

Penicillin

A group of antibiotics derived from natural extracts of the Penicillium mold and semisynthetic derivatives.

1940

Many natural fermentation products first developed early in this year

IM injection

The first penicillin in extensive clinical use is usually given by?

Penicillin G

virtually non toxic to human cells, thus can be given safely in large amounts

penicillinase-producing staphylococci

Pen G is still considered a first line drug against most gram positive bacteria except?

Penicillin V

A semisynthetic analogue of penicillin G with similar spectrum of activity, more completely absorbed orally, and not destroyed by gastric acid.

Penicillium mold

The penicillin group of antibiotics includes natural extracts from several strains of the P__________ m___ and a number of semisynthetic derivatives of many natural fermentation products first developed in the early 1940’s.

epinephrine

Make sure that this is available to counteract a severe allergic reaction.

1 hour

Food may decrease the absorption of many oral penicillin, so those penicillin should be taken with a full glass of water _________ before food intake or 2 hours after.

Amoxicillin and Bacampicillin

__________________ are penicillin that are unaffected by food.

What is Broad Spectrum Penicillin?

Penicillins used to treat both gram positive and negative bacteria, including Escherichia Coli, Haemophilus Influenzae, and Salmonella.

Shigella

Examples of gram negative bacteria: Escherichia Coli, Haemophilus Influenzae, and _____

Unasyn

Ampicillin + Sulbactam

Augmentin

Amoxicillin + Clavulanate

What is Penicillinase Resistant Penicillin?

Penicillins used to treat penicillinase-producing staphylococcus aureus.

Dynapen

Dicloxacillin Sodium

Pseudomonas Aeruginosa

Extended Spectrum Penicillin are effective against _____________________, gram negative Bacillus, Proteus, Serratia, Klebsiella Pneumoniae, Enterobacter and Acinetobacter

Benefits of Penicillin

Effective against a wide range of bacterial infections, treats respiratory tract infections, skin and soft tissue infections, and can prevent complications from certain infections.

Adverse Effects of Penicillin

Allergic reactions, gastrointestinal disturbances, potential for antibiotic resistance development, and rare serious side effects like kidney damage or blood disorders.