Drug, alcohol and nicotine dependence

Methadone

Treats drug dependency. Class-long acting full agonist at mu opioid receptors. Decreases withdrawal between doses, deceased cravings and euphoric effects. Side effects are Constipation, sweating, sextual dysfunction and tooth decay

Acamprosate

Treats alcohol dependence. Class-NMDA receptor antagonist. Helps restore balance to neurotransmitters in the brain, reducing cravings and withdrawal symptoms. Positive allosteric modulator at GABA-A receptors, restoration of normal activity in glutamate and GABA-ergic systems. Side effects may include diarrhea, nausea, and insomnia.

Naltrexone

Treats alcohol dependence. Class-Mu opioid antagonist. Reduces cravings and withdrawal symptoms. It blocks the euphoric effects of alcohol, helping to prevent relapse. Side effects may include nausea, headache, and dizziness.

Varenicline

Treats nicotine dependence. Class-Partial agonist at a4b2 nicotinic receptors. Blocks ability of nicotine to activate these receptors. Reduces withdrawal symptoms. Side effects are Nausea, Insomnia, abnormal dreams and seizures