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First step
Stressor is perceived
Second Step
Hypothalamus releases CHR into hypophyseal portal system
Third Step
The anterior pituitary releases ACTH into systemic blood circulation
4.
Adrenal cortex releases GC into systemic blood circulation
5.
Systemic GC stimulate metabolism and suppress immune function
6.
GC’s circulate back to brain and stimulate GC receptors providing negative feedback at multiple levels