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Functions of the Urinary System
1. Removes waste from the blood
2. Maintains electrolyte balance
-Effect hydration, blood pH & muscle/nerve
function
3. Effects blood pressure
The kidney regulates
key electrolytes and helps regulate blood
pressure.
Water
Increased Antidiuretic hormone (ADH) causes water
reabsorption in renal tubules of the kidneys. Decreased levels increase urine production.
Sodium Regulation
ADH and aldosterone regulate osmolarity
(amount of solute per unit volume of water in body).
Increased ADH decreases sodium concentration and aldosterone
increases sodium concentrations during hyponatremia.
Potassium
Aldosterone produced by the adrenal gland regulates
potassium which is necessary for proper muscle function.
Hyperkalemia (high serum potassium) causes the release of
aldosterone which causes excretion of potassium by the kidneys, thus lowering serum potassium.
Blood Pressure
Low blood pressure is sensed by the kidneys
that then produce renin in the arterioles that then produces angiotensin II that increases blood pressure.
Basic Physiology of the Kidneys
Filtration
reabsorption
secretion
- Takes place in renal corpuscle
- Water, electrolytes, sugars, amino acids, pass from blood to glomelular capsule as filtrate
- Occurs in renal tubule
- Some useful substances returned to blood (electrolytes, water etc.)
- Renal tubules secrete uric acid and ammonia etc.
The Nephron
Functional units of the kidneys
Consists of:
1. Renal Corpuscle - Contains Glomerulus & Glomerular Capsule (Bowman’s Capsule)
2. Renal Tubule
The Kidney
• Retroperitoneal
• Left is longer and more narrow than right
• Upper poles more medial and posterior than lower poles
The Kidney- anatomy
• Hilum
Notch in kidneys where blood vessels, lymph vessels, nerves and ureters enter kidney.
The Kidney- anatomy
Renal Sinus
fat filled space surrounding the renal pelvis.
the kidney anatomy
• Renal Medulla
Contain collecting tubes that drain fluid from renal tubules.
the kidney anatomy
• Renal Cortex
Outer portion of kidney that contains the nephrons (functional units of kidneys) consisting of 1. (A) glomeular capsule (Bowman’s Capsule) and (B) Glomeuli – Capillaries that filter the blood and 2. Renal tuble (passes fluid from the renal pyramids to the renal pelvis)
the kidney anatomy
• Renal Pyramids
Renal columns – Extensions of cortex into renal pyramids that serve to anchor the cortex.
the kidney anatomy
Calyces
4-13 minor/2-3 major
– collect urine from renal pyramids and transfers to renal pelvis.
the kidney secretes…
1 – 2 liters of urine per day
Ureters
length
location
function
enter
•10 – 12 inches in length
• Retroperitoneal
• Function by perisatalsis
• Enter on posteriolateral surface of
bladder (trigone)
The Urethra
length male/female
•1.5 inches in females (1 inch anterior to vaginal opening)
• 7 – 8 inches in male (travels through prostate)
The Bladder & Prostate
location
function
how much fluid does it hold
how is it imaged
•Prostate inferior to bladder
• Posterior to pubic symphysis
• Can encroach on urethra (BPH)
• Maintains viability or motility of sperm
• Bladder anterior to rectum and vaginal canal
• Bladder holds max. of 500 ml of fluid
• The prostate is commonly imaged with
transrectal ultrasound
Types of Urinary Studies
antegrade
- Bolus injection nephrotomography
- Infusion Nephrotomography
- Intravenous Urography (IVU)
- Pyelography
Types of Urinary Studies
retrograde
- Retrograde Urography
- Cystoureterography
- Cystourethrography
Patient Preparation - IVU
• Low residue diet 1 – 2 days prior to exam
• Light evening meal
• Laxative
• Well hydrated
• NPO after midnight
Patient Preparation - IVU
bun
creatinine
+3 more
• BUN (8 – 25 mg/dl)
• Creatinine (.6 – 1.5 mg/dl)
glomerlular filtration (GFR) 90-120
(below 60 is compromised function)
diabetic history (glucophage)
HX of heart disease, allergic asthma, current medications
CONTRAST HISTORY
1920’s
1950’s
1985
Serendipitous discovery of the unique x-ray absorption properties of iodine during treatment of syphilis
First clinically usable media introduced!
All were considered ionic, high-osmolar contrast media
(HOCM)
FDA approves use of nonionic, low-osmolar contrast media (LOCM)
Ionic Contrast Media
molecules must:
contain:
also known as:
osmolality:
high incidence:
• Molecules must disassociate
– Contain iodine, anions and cations that may
interact with CNS
• Also known as High-Osmolality Contrast
Media (HOCM)
– Osmolality 1000-2000 mOsm/kgH20
– High incidence of reactions and complications as
compared to Low-Osmolality
Non-Ionic CM
also known as
media
osmolality
does NOT
cost
x
x
Also known as Low-Osmolality Contrast
Media (LOCM)
– osmolality 290-860 mOsm/kgH20
• Does not disassociate into ions
• Higher cost
• Reduced complications
• pH range 5.5-7.4
Ionic Monomer
• May be ionic monomers (one
iodinated benzene ring) or
dimer (2 linked benzene rings)
• Ions may interact with CNS
• Contain carboxyl group molecule
to achieve high water solubility
Nonionic Dimer
•May also be monomers (one
iodinated benzene ring) or
dimer (2 linked benzene rings)
• No ions to interact with CNS
• Contain no carboxyl group, but have
several hydroxyl groups per molecule
to achieve water solubility
Elimination of the carboxyl group
Nonionics also have
and the ions result in less reactions
from nonionic iodinated contrast media.
lower osmolality (3:1) than ionic compounds (3:2)
Non-Ionic CM
viscosity
Viscosity is higher in non-ionic contrast
-Viscosity of water is 1 centipoise (cps)
-Viscosity of blood hematocrit 40%= 3-4 cps
– Decreased by warming
• Optiray® 320
25° C = 9.9 cps
37° C = 5.8 cps
JCAHO no longer recommends the use of
warmer units due to possible infection control
Contrast Agents - IVU
Reactions are related to:
All urinary studies use water soluble iodinated
contrast (50% – 70% iodine) and may cause
adverse reactions in the body.
1. Osmolality
2. Ionic Vs nonionic structure
3. Viscosity
Signs of Allergic Reactions
rule of 5
Most reaction occur within 5” of injection
Rule of Five – Most reactions occur within 5”
of injection. These only occur in 5% of patients and
only 5% of those are life-threatening.
Reaction of Symptoms
• Increased pulse rate
• Pallor
•Cool, clammy skin
• Urticaria
• Dyspnea
• Pharyngeal constriction
• Fall in BP of 30 mm or more below baseline
may indicate an anaphylactic reaction
Early (Mild) Signs
Late Signs (Serious)
•Restlessness
• Urticaria
•Pharyngeal constriction
•Arrhythmias
•Dramatic fall in BP
Iodinated CM Reactions
Cardiopulmonary Effects
• Pulmonary edema in preexisting heart
disease
• Increased cardiac failure especially right-sided
failure
• RBCs shrink due to osmotic gradient
– Rigid RBCs may not pass through small
capillaries resulting in tissue anoxia
Iodinated CM Reactions
Renal effects
– Osmotic diuresis
– Loss of potassium, calcium, phosphorus,
urea, uric acid, magnesium, water and
sodium
– Dehydration can occur
– Possible nephrotoxicity
CONTRAST-INDUCED NEPHROTOXICITY
• 98% of all iodinated media is eliminated by kidneys
• Renal blood flow first increases then decreases for several hours
CONTRAST-INDUCED NEPHROTOXICITY
By definition is when there is:
•A sudden, significant worsening of renal
function after receiving intravascular
contrast.
• 20-50% rise in baseline creatinine
or a rise in serum creatinine of at least
0.5 mg/dL within 48 hours.
Iodinated CM Reactions
Anaphylactoid Reactions
• Mild to severe
– 94% of severe and fatal reactions occur with in 20 minutes of injection
– 60% within 5 minutes
– Delayed reactions may occur days or weeks after injection but are usually mild
May be prevented by:
– Premedicate with steroids and antihistamines if known allergy to contrast or high risk (asthma,multiple allergies)
– Emergency medication must be readily available
Incidents of contrast Side Effects
Overall Complications
Ionic = 5%, Non-ionic = 1%
Death
Ionic
1:40,000 – 1:70,000
Non-ionic
1:200,000
Nephrotoxicity is 10% (higher in diabetes
mellulitis and dehydration), usually resolves
spontaneously
Patient Preparation for IVU
•Low residue diet 1-2 days prior
•Light evening meal day before exam
•Laxative
•Well hydrated
•NPO after midnight
Equipment - IVU
•Tomographic Table- CR equipment
• Markers
•14 X 17 and/or 10 X 12 IR’s with analog studies
• Compression band – Placed at level of ASIS
• Emergency drug cart or drug box
A doctor (preferably the radiologist must be
immediately available)
Radiation Protection
• Males shielded with lead below symphysis
when possible – can use shadow shield
• Females hard to shield
• Good collimation is best protection
IVU - exposure
at the end of expiration
Intravenous Urography
Abdominal masses
Renal cysts or tumors
Pyelonephritis
Hydronephrosis
Evaluation of trauma to kidneys
Post-operative kidney function
Renal hypertension
Intravenous Urography
CONTRADICTIONS
Renal failure
Previous allergic reaction with non-ionic contrast
(in some cases patient may be pre-medicated)
Anuria
Non-Ionic Contrast is Recommended for:
• Elderly patients
• Patients with asthma
• Patients with a previous contrast reaction
• Patients with cardiovascular arrhythmias
•Patients with a slight increase in BUN or
Creatinine
• Patients with sickle cell anemia
• Patients with diabetes mellitus
• Multiple myeloma patients
Preliminary Steps for the IVU
•Scout film
• Foot board
• Pillow under knees
Explain procedure/ get hx
Contrast Administration
•30 – 100 cc for adult (1 cc per/lb. up to max. of
150 cc)
• Amount in children depends on weight and age
• Sex of patient must be considered
• Nephrogram phase occurs first (within in first 5”)
• Pelvicalyceal shows up within 2 – 8 minutes
Common Projections
Normally AP projections ranging from 3” – 20” (minutes)
Routine Projections include a
Scout
Tomograms of kidneys
AP
Both obliques
Upright post-void.
IVU
Supplemental Positions
•Trendelenberg
• Prone Position
•Lateral Position
IVU
_ x _
AP Projection
CR
SS
14 X 17 IR
Position of the Part:
• Patient supine
•MSP centered to table
Central Ray:
• Centered to the midline at the iliac crests
(images must show kidneys, ureters, bladder)
Structures Shown:
• Kidneys, ureters, bladder
• Short-scale contrast (80 – 85 kVp used)
AP Oblique Projections
RPO and LPO Positions
POS
CR
SS
14 X 17 IR
Position of the Part:
• Patient supine
• MCP forms 30° angle to IR
• Center IR to iliac crests
Central Ray:
• 2” lateral to the midline on the elevated side
• Centered at the iliac crestsStructures Shown:
• Kidneys, ureters, bladder
• Kidney closest to IR is perpendicular to IR,
kidney farther from IR will be parallel to IR
Nephrotomography/Nephrourography
Bolus Nephrotomography
EXAM PROCEDURE
•Demonstrates renal parenchyma
• Indications include evaluation of renal
hypertension, cysts and tumors
•Scout film
•Large bolus injection
• AP projection of abdomen during arterial phase
• Tomographic images during nephrotic phase
(within 5 minutes of injection)
• Tomographic section in posterior 1/3rd of
abdomen (commonly 9, 10, 11 cm)
Nephrogram Pathology
Decreased uptake during nephrogram phase at 1 minute
tomogram and small right kidney indicates right renal arterial stenosis.
Percutaneous Antegrade Pyelography
Direct stick of the kidney with injection of
positive contrast into renal pelvis
• Used to evaluate hydronephrosis
• Largely replaced by ultrasound
Retrograde Urography
Direct catherization of ureters with a
ureteroscope with injection of positive contrast
to visualize the bladder ureters and renal pelvis
•Used in cases of renal insufficiency/allergies
to iodine
• Shows structure well, but little about function
Retrograde Urography
Procedure
Operative procedure requiring surgical asepsis
•Patient is supine, knees in flexed (lithotomy
position in stirrups)
• Cystoscope inserted through urethra into bladder
• Catheter inserted into ureters
• Colored dye injected IV to check renal function
Contrast injected to visualize renal pelvis/ureters
Retrograde Urography
images
supplemental images
Three images obtained (14X17, centered at L -3):
1. AP scout
2. Pyelogram image – head of table lowered
10 - 15°
3. Ureterogram image – head of table elevated
35 - 40°
Supplemental Images: RPO/LPO positions
Cystography
Radiographic visualization of the bladder
using positive contrast media
Cystoureterography
Shows bladder & lower ureters
Cystourethrography
Shows bladder and urethra
Cystography
Indications
•Vesicoureteral reflux
• UTI
• Urethral strictures
• Bladder trauma
• Neurogenic bladder
Cystography
Preparation
•Table covered with radiolucent plastic sheet
• Urine collection receptacle
• Perineal care prior to exam
• Proper aseptic technique
• Catherization of patient or use of acorn plug
for female patients
Cystography
Procedure
•Contrast is injected into the bladder
• Routine projections include AP axial, both
obliques and lateral
• Chassard-Lapine projection may be used
supplementally to show posterior bladder &
lower ureters
Cystography
AP Axial Projection
POS
CR
SS
10 X 12 IR lengthwise
Position of the Part:
• Patient supine
• MSP centered to grid
• Center IR 2 inches above pubic symphysis
(at the pubic symphysis for voiding studies)
• Expose at end of respiration
Central Ray:
• Angled 10 - 15° caudal & centered to IR
Structures Shown:
Bladder
Lower ureters may be shown when reflux is
present
AP Oblique Projection
RPO or LPO Position
IR
POS
CR
SS
10 X 12 IR lengthwise
Position of the Part:
• Patient supine & rotated 40 - 60°
• Abduct upper thigh away from bladder
• Center IR 2 inches above pubic symphysis &
2 inches medial to upper ASIS
Central Ray:
Perpendicular & centered to IR
Note: 10 ° caudal angle when bladder neck
and urethra are areas of interest
Structures Shown:
Bladder
Ureters when reflux present
Lateral Projection
POS
CR
SS
Position of the Part:
• Patient in lateral recumbent
• MCP centered to grid
• IR centered 2 inches above pubic symphysis
Central Ray:
Perpendicular and centered to grid
Structures Shown:
Anterior, posterior and base of bladder walls
Male Cystourethrography
AP Oblique Projection
IR
POS
CR
10 X 12 LW
Part Position:
• Patient supine & rotated 35 - 40° for entire study
• IR centered to the superior border of pubic
symphysis
• Patient’s elevated thigh extended
• Patient’s lower leg flexed
Central Ray: Perpendicular & centered to the IR
at pubic symphysis
Male Cystourethrography
AP Oblique Projection
Procedure
SS
•The patient injected with urethral syringe
loaded with a Brodney clamp
• Penis extended along soft tissue of leg
• Exposures taken during filling and voiding
Structures Shown:
Bladder and urethra
Female Cystourethrography
AP Projection
IR
CR
PROCEDURE
SS
Position of the Part:
• Patient supine
CENTRAL RAY
•Centered at the superior border of the
pubic symphysis
• Angled 5° caudal
Procedure:
• Perform endoscopy
• Catherize bladder & drain, remove catheter
• Syringe with soft-rubber acorn used to inject
contrast
• images taken during filling and voiding
• AP and oblique projections
(35 - 40°) also be required
Structures Shown:
Bladder and urethra
Female Cystourethrography
Metallic Bead Chain Method
Procedure:
Images Show:
Shows abnormalities associated with stress incontinence
•PROCEDURE
Chain threaded into urethral orfice
• Foley inserted and bladder drained
• Contrast instilled and catheter removed
• AP and lateral images taken at rest and
during straining
•IMAGES SHOWN
Anatomic bladder changes (shape & position)
• Position of bladder floor
• Position of proximal urethral orfice
• Angle of inclination of urethra