MNT II Lecture Midterm I

Pharmacology

study of drugs, properties and their effects on the body

pharmacotherapy

using drugs to treat medical issues and disease

pharmacokinetics

the study of how drugs are absorbed, distributed in the body, metabolized, excreted

passive diffusion

• does not need

• goes fast

facilitated transport

• also passive diffusion

• uses transmembrane proteins (channels)

where does drug metabolism happen

• liver

• distributed to other target tissues

drug excretion

• urine

• biliary system

• bowels

• breast milk

• glands

GI Absorption altered

• consumption w/ food

• vomiting

• diarrhea

• transit time issues

• SA diff.

• circulation loss

• competition for carriers

metabolism is altered by…

• age: lean tissue shifts, altered absorption metabolism

• organ function

• genetics

• concurrent use of other meds

excretion is altered by…

• urine pH

• competitors for active transport

• urine flow rates

• creatinine clearance

Main reason for renal failure

• diabetes (atherosclerotic plaque build up, inc P, blows out nephrons (can’t grow back)

  • also high BP and drugs (attempted OD)

Drugs impact on nutrient ingestion

they can cause symptoms like…

• nausea

• vomitting

• diarrhea

• constipation

• hunger

• appetite loss

• weight loss

• weight gain

How do drugs impact nutrient metabolism