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Block 2
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What are the components of the epidemiologic triad?
Host
Agent
Environment
What is infectivity?
the ability to penetrate and reproduce in a host; does not imply disease
What is pathogenicity?
the ability to cause clinical disease
What is virulence?
ability to cause severe disease or death
What is a natural host?
maintains the infection in the endemic state
What is the amplifier host?
supports rapid multiplication of the agent
What is the dead-end host?
does not normally transmit the agent
What is the environment contribution?
is where the infectious agent normally lives, grows, and multiplies (the reservoir)
What is needed for infection to occur?
portal of exit
portal of entry
What is horizontal transmission?
spread between contemporaries via touching, biting, scratching, contaminated droplets, urine/body fluids, or reproductive discharge
What is vertical transmission?
mother-to-offspring (transplacental or transmammary)
What is direct transmission?
spread through direct contact with an infected animal, its tissues, ot fluids, or by droplet (aerosol) projection
What is indirect transmission?
spread through intermediary vehicle or vector
What is vehicle transmission?
inanimate object or fomite, ingestion from contaminated food or water or biological products
What is vector-born transmission?
transfer by an arthropod
What is a mechanical vector?
no multiplication or development of the agent
What is a biological vector?
allows multiplication or development of the agent
What are airborne (small particle) transmission?
travel large distances, remain suspended for extended periods
What is the epidemiologic triad for Bovine Spongiform Encephalopathy (BSE)?
Agent/Reservoir: prion
Transmission: food-borne disease by feeding ruminants protein supplements from other ruminant tissue
Intervention: ban feeding ruminant-source protein feeds to cattle
What is the epidemiologic triad for Rift Valley Fever (RVF)?
Agent/reservoir: aedes mosquito
Amplifying host: ruminants
Transmission: zoonotic transmission to humans occurs through direct contact with the blood or organs of infected animals
What does endemic mean?
disease occurs at an expected frequency
What does epidemic mean?
disease occurs at a greater than expected frequency
What does sporadic mean?
disease occurs occasionally as a single case or in small clusters