Adrenergic Antagonists
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24 Terms
Adrenergic antagonist
blockers or sympatholytics
classified based on alpha/beta affinity
Alpha blockers
antagonists w/ affinity for alpha1
vasodilation = decrease BP
Phenoxybenzamine
alpha-1 and 2 blocker
decrease BP
epi reversal
TU: pheochromocytoma
AE: postural HTN, N/V
Phentolamine
alpha-1 and 2 blocker
DOA: 4 hr
TU: pheochromocytoma
AE: postural HTN
CL: CAD leads to arrhythmia, angina
Tamsulosin
selective alpha-1A blocker
inferior CV outcomes
TU: HTN glucose metabolism, BPH tx
Decrease BP with vasodilators
TU: HTN not alone
prazosin
doxazosin (AE: inhibits ejaculation, floppy iris)
alpha-1 blocker
Yohimbine
selective alpha-2 blocker
increase SNS outflow
E.D. supplement
Cl: cardiac d2, psych, renal
Reserpine
alpha blocker
affects NT uptake/release
depletes NE/dopamine/serotonin
replaced by better HTN txs
Beta blockers non-selective
equal beta-1 and beta-2 activity
Propranolol
non-selective beta blocker
TU: HTN, MI, angina, migraine, hyperthyroidism
AE: bronchoconstriction, sexual impairment, arrhythmias, metabolic disturbance, CNS s.e.
Nadolol
non-selective beta blocker
long DOA
DOA: 12-24 hr
TU: glaucoma tx
timolol (occasionally HTN)
carteolol
non-selective beta blocker
Pindolol
non-selective beta blocker
good for bradycardia
not a pure antagonist
Beta-1 cardioselective
TU: HTN, stable angina, cardiac-F
Betaxolol
beta-1 cardioselective
DOA: 12-24 hr
TU: glaucoma tx
Acebutolol
beta-1 cardioselective
good for bradycardia
not a pure antagonist
TU: chronic hear failure pts
bisoprolol
metoprolol
beta-1 cardioselective
Esmolol
beta-1 cardioselective
short ½ life, IV amin during procedures
Atenolol
beta-1 cardioselective
TU: decrease BPN
Nebivolol
beta-1 cardioselective
release nitric oxide
vasodilation
Alpha blockers non-selective
alpha-1 block causes orthostatic HTN, dizziness
decrease peripheral vasoconstriction
Carvedilol
non-selective alpha blocker
TU: chronic heart failure pts
Labetalol
non-selective alpha blocker
TU: HTN in pregnancy (methyldopa alt)
IV during HTN emergency
Adrenergic antagonist general effects
“REST & DIGEST”
Reduced HR
Elevated airway resistance (bronchoconstriction)
Slowed conduction (decrease HR)
TPR reduced
&
Decreased BP
Impaired SNS relexes
GI motility increase
Erectile dysfunction
Sedation (decrease anxiety)
Tiredness/fatigue
Note 
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