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How do T-cell receptor and immunoglobulin gene rearrangements proceed?
T-cell receptor and immunoglobulin gene rearrangements proceed in a defined sequence.
What happens after each recombination event in T-cell or B-cell development?
After each recombination event, the protein product is tested for functionality.
What happens if a T-cell or B-cell fails to produce a functional protein product?
If the protein product is not functional, the developing T cell or B cell undergoes apoptosis.
What happens if a T-cell or B-cell successfully produces a functional protein?
The cell is allowed to proceed to the next step in development.