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Chapters 1 and 2 Study Guide 1.1 Classifying matter (what it is and how we name it) Physical state Solid: fixed shape and volume (particles tightly packed; strong intermolecular forces). Liquid: fixed volume but shape adapts to container (particles close but can move past each other). Gas: no fixed shape or volume — fills container (particles far apart; weak interactions). Pure substance vs mixture Pure substance: one type of “stuff” with fixed composition. Element: pure substance that cannot be chemically broken into simpler substances (e.g., O₂ gas consists of oxygen atoms). Compound: pure substance made of two or more elements chemically bonded in fixed ratio (e.g., H₂O). Mixture: two or more substances physically combined; components keep their chemical identities. Homogeneous mixture: uniform throughout (solution like salt water). Heterogeneous mixture: non-uniform (e.g., sand in water). Particles Atom: smallest unit of an element that retains element identity (e.g., one carbon atom). Molecule: two or more atoms bonded together (could be same element, e.g., O₂, or different, e.g., CO₂). Ion: atom or group of atoms with net electric charge (cation = positive, anion = negative). How to classify — short checklist Is composition fixed? yes → pure substance (element or compound). no → mixture. Is it made of single type of atom? yes → element. If different elements bonded → compound. Is it uniform? yes → homogeneous; no → heterogeneous. 1.2 SI units & common prefixes Base SI units you need: Length: meter (m) Mass: kilogram (kg) — note: kg is base unit (not g), but we often use grams (g). Time: second (s) Temperature: kelvin (K) Amount of substance: mole (mol) Common prefixes (multipliers): kilo- (k) = 10³ = 1,000 e.g., 1 km = 1,000 m centi- (c) = 10⁻² = 0.01 e.g., 1 cm = 0.01 m milli- (m) = 10⁻³ = 0.001 e.g., 1 mm = 0.001 m Tip: memorize that kilo = 1000, centi = 1/100, milli = 1/1000. 1.3 Scientific notation Why: makes very large or very small numbers easier and reduces error. Format: a \times 10^n where 1 ≤ |a| < 10 and n is integer. Examples 0.000345 = 3.45 \times 10^{-4}. 6,200,000 = 6.2 \times 10^{6}. To convert: move decimal left for positive exponent, right for negative. 1.4 Significant figures (sig figs) & uncertainty What sig figs mean: digits in a measurement that are known reliably plus one uncertain digit (last digit). Rules for counting sig figs Nonzero digits are always significant: 245 → 3 sig figs. Zeros between nonzero digits are significant: 2005 → 4 sig figs. Leading zeros (to left of first nonzero) are NOT significant: 0.0072 → 2 sig figs. Trailing zeros in a number with a decimal are significant: 2.300 → 4 sig figs. Trailing zeros in a whole number without a decimal are ambiguous — use scientific notation to show significance: 1200 (ambiguous) → write 1.200×10³ to show 4 sig figs or 1.2×10³ to show 2. Relationship to uncertainty: the last sig fig is the estimated digit — it indicates the measurement’s uncertainty level. 1.5 Sig figs in calculations Multiplication / Division: answer has same number of sig figs as factor with fewest sig figs. Example: 2.5 \times 3.42 = 8.55 → 2 sig figs → round to 8.6. Addition / Subtraction: align decimal places; answer has decimal places equal to the quantity with fewest decimal places. Example: 12.11 + 0.3 = 12.41 → fewest decimals = 1 decimal → round to 12.4. Always follow these rules and only round at the end of multi-step calculations (keeping extra guard digits during intermediate steps). 1.6 Accuracy vs precision Accuracy: how close a measurement is to the true/accepted value. Precision: how repeatable measurements are (how close they are to each other). Illustration (dartboard): All darts close to bullseye → accurate and precise. All darts clustered but far from bullseye → precise but not accurate. Darts spread out but centered on bullseye on average → accurate but not precise. 1.7 Derived units: volume & density Volume: for regular shapes use geometry (e.g., m³ or L = dm³). Common lab units: mL (1 mL = 1 cm³). Density: \rho = \dfrac{\text{mass}}{\text{volume}}. Common units: g/mL or g/cm³ for solids/liquids; kg/m³ in SI. Rearrangements \text{mass} = \text{density} \times \text{volume} \text{volume} = \dfrac{\text{mass}}{\text{density}} Example (lab / irregular object): Object mass = 12.43 g. Volume by displacement = 3.10 mL. Density = 12.43 g ÷ 3.10 mL = 4.0097 g/mL → with sig figs: three sig figs (3.10 has 3 sig figs; 12.43 has 4) → 4.01 g/mL. 1.8 Dimensional analysis (unit conversions) Key idea: multiply by conversion factors that equal 1 (units cancel). Worked example: convert 2.50 miles → meters. 1 mile = 1609.34 m. 2.50\ \text{mi}\times \frac{1609.34\ \text{m}}{1\ \text{mi}} = 4023.35\ \text{m}. Sig figs: 2.50 has 3 sig figs → answer must have 3 sig figs → 4.02 × 10³ m. 1.9 Practice problems (with steps + sig figs) Problem A — Scientific notation Convert 0.000462 to scientific notation. Move decimal 4 places right: 4.62 \times 10^{-4}. Problem B — Multiplication with sig figs Compute (3.60 \times 2.1). Raw: 3.60\times2.1 = 7.56. Sig figs: 3.60 (3 sig figs), 2.1 (2 sig figs) → result 2 sig figs → 7.6. Problem C — Addition with sig figs Compute 12.11 + 0.3 + 0.042. Align decimals; fewest decimal places = 1 (from 0.3) → round final to 1 decimal place. Sum = 12.11 + 0.3 + 0.042 = 12.452 → round to 12.5. Problem D — Density (irregular object) Mass = 24.68 g; initial water in graduated cylinder = 15.0 mL; final = 17.35 mL. Volume displaced = 17.35 − 15.0 = 2.35 mL (note: 15.0 has 3 sig figs so difference has 3 sig figs). Density = 24.68 ÷ 2.35 = 10.500 ≈ 4 sig figs? But check sig figs: mass 24.68 (4 sig figs), volume 2.35 (3 sig figs) → result to 3 sig figs → 10.5 g/mL. Chapter 2 — Atomic structure, periodic table, bonding, naming 2.1 Historic experiments — what they showed and why they matter J.J. Thomson (late 1800s) — cathode ray experiment What he did: passed a beam (cathode ray) through electric & magnetic fields and measured deflection. Observation: beam deflected toward positive plate → beam composed of negatively charged particles. Discovery: existence of the electron — a very small, negatively charged particle present in atoms. Model implication: atoms are not indivisible; they contain subatomic particles. Thomson proposed the “plum pudding” model: a positive “soup” with embedded electrons. Significance: first discovery of subatomic particle; proved atoms have internal structure. Ernest Rutherford (early 1900s) — gold foil experiment What he did: fired alpha particles (positively charged) at very thin gold foil and detected scattering angles. Observation: most alpha particles passed straight through, but a small fraction deflected at large angles; some bounced back. Conclusion: atom is mostly empty space with a tiny, dense, positively charged nucleus that contains most mass — electrons orbit around that nucleus. Model implication: replaced plum pudding with nuclear model (nucleus + orbiting electrons). Why this matters: Rutherford explained the large-angle deflections that Thomson’s model couldn’t; introduced the nucleus concept — foundation for modern atomic structure. 2.2 Atomic number, mass number, isotopes Atomic number (Z): number of protons in nucleus → defines the element. Mass number (A): total number of protons + neutrons in nucleus (integer). Isotopes: atoms of same element (same Z) with different numbers of neutrons (different A). Example: carbon-12 (^12C) and carbon-14 (^14C). Isotopic notation: {}^{A}{Z}X^{\text{charge}} Example: an ion of chlorine with 17 protons and 18 neutrons and −1 charge → {}^{35}{17}\text{Cl}^{-} (35 = 17+18). Average atomic mass: weighted average of isotopic masses using natural abundances (found on periodic table). The periodic table lists average atomic mass (not integer mass numbers) because natural samples are mixtures of isotopes. 2.3 Example: average atomic mass (Neon) Given isotopes (typical values): ^20Ne mass = 19.992440 amu, abundance = 90.48% (0.9048) ^21Ne mass = 20.993847 amu, abundance = 0.27% (0.0027) ^22Ne mass = 21.991386 amu, abundance = 9.25% (0.0925) Average atomic mass: (19.992440)(0.9048) + (20.993847)(0.0027) + (21.991386)(0.0925) = 20.1800\ \text{amu (approx.)} This is the kind of number you’ll see on the periodic table: 20.180 amu. Procedure (general): multiply each isotope mass × its fractional abundance, then sum. 2.4 Writing atomic/ionic symbols and counting particles Given: protons, neutrons, electrons, and charge — decide isotope notation or ion symbol. Example 1: 17 protons, 18 neutrons, 17 electrons → neutral chlorine atom ^35Cl (since A = 17 + 18 = 35). Symbol: {}^{35}_{17}\text{Cl}. Example 2: 11 protons, 12 neutrons, 10 electrons → net charge +1 (lost 1 electron) → sodium ion {}^{23}_{11}\text{Na}^{+} (A = 23). How to check: protons = atomic number (Z) → identifies element. electrons = protons − charge (if charge positive, fewer electrons). mass number A = protons + neutrons. 2.5 Ionic vs covalent (molecular) compounds Ionic compounds Formed when electrons are transferred from a metal to a nonmetal (forming cations and anions). Bonding characterized by electrostatic attraction between oppositely charged ions. Usually full formula is a formula unit (empirical ratio). Often solids with high melting points and conduct electricity when molten or dissolved. Example: NaCl (Na⁺ and Cl⁻). Covalent (molecular) compounds Formed when two nonmetals share electrons to achieve noble gas configuration. Bonds are electron-sharing; molecules have discrete units. Example: H₂O, CO₂. Rule of thumb: metal + nonmetal → usually ionic. nonmetal + nonmetal → usually covalent. 2.6 Using the periodic table to get information From an element’s location: Atomic number → number of protons (top of box). Atomic mass (average) → usually decimal number beneath symbol. Group (column) number → similar chemical behavior and valence electrons. Period (row) → number of electron shells occupied. Metals/Nonmetals/Metalloids: left side metals, right side nonmetals; staircase demarcates metalloids. Common ion charges: Groups 1A → +1, 2A → +2, 7A (halogens) → −1, 6A → −2, etc. Transition metals: central block (d-block). Halogens: Group 17 (F, Cl, Br, I…). Noble gases: Group 18 (He, Ne, Ar…). 2.7 Writing chemical formulas Ionic compounds (simple) Balance total positive and negative charges to get neutral compound. Example: Al³⁺ and O²⁻ → least common multiple of 3 and 2 = 6 → need 2 Al³⁺ (2×+3=+6) and 3 O²⁻ (3×−2=−6) → formula Al₂O₃. With polyatomic ions Treat polyatomic ion as a unit; balance charges. Use parentheses when more than one polyatomic unit is needed: e.g., calcium nitrate = Ca²⁺ + NO₃⁻ → need two NO₃⁻ → Ca(NO₃)₂. Naming Ionic: cation name (metal) first, then anion name (nonmetal with −ide ending) or polyatomic ion name. For transition metals that can have multiple charges, use Roman numeral for charge (iron(III) chloride = FeCl₃). Molecular (binary nonmetal compounds): use prefixes (mono-, di-, tri-, etc.) to show number of each atom (CO₂ = carbon dioxide). Common polyatomic ions (memorize these) NH₄⁺ ammonium NO₃⁻ nitrate SO₄²⁻ sulfate CO₃²⁻ carbonate OH⁻ hydroxide PO₄³⁻ phosphate ClO₄⁻ perchlorate 2.8 Hydrates Definition: a compound that contains water molecules in its crystalline structure: written as \text{salt} \cdot x\text{H}_2\text{O}. Example: copper(II) sulfate pentahydrate = CuSO₄·5H₂O. Naming: name ionic compound then add prefix for water number + “hydrate” (e.g., decahydrate, pentahydrate). Finding empirical hydrate formula (lab procedure) Mass of hydrate (before heating) — measured. Heat to remove water → mass of anhydrous salt measured. Mass of water lost = mass hydrate − mass anhydrous. Convert both masses to moles: moles anhydrous = mass anhydrous ÷ molar mass of anhydrous salt. moles water = mass water ÷ 18.015 g/mol. Compute mole ratio: moles water ÷ moles anhydrous → round to nearest small whole number → that’s x in salt·x H₂O. Worked lab example (complete): (This matches labs you described.) Given: Mass hydrate = 2.564 g Mass anhydrous = 1.622 g Assume the anhydrous formula is CuSO₄ (molar mass = 159.609 g/mol) Steps: Mass water = 2.564 − 1.622 = 0.942 g. Moles anhydrous CuSO₄ = 1.622 g ÷ 159.609 g/mol = 0.010162 mol. Moles water = 0.942 g ÷ 18.015 g/mol = 0.052290 mol. Mole ratio water : salt = 0.052290 ÷ 0.010162 = 5.15 ≈ 5 → formula CuSO₄·5H₂O. Why rounding to whole number: water molecules must be whole; experimental values near whole numbers are rounded to the nearest integer (if close enough — e.g., 2.99 → 3). 2.9 Stoichiometry & dimensional analysis reminders Always write units and let them cancel. Carry at least one extra guard digit through calculations; only round final answer to correct sig figs. For atomic/molecular calculations you’ll often use Avogadro’s number: 6.022\times10^{23} particles/mol. Calculations and practice problems from your list — solved Identifying sig figs — quick answers 0.004500 → 4 significant figures (4500 with leading zeros not significant; trailing zeros after decimal are significant). 1200 → ambiguous; writing as 1.200×10³ shows 4 sig figs; 1.2×10³ shows 2. Example: Putting numbers into/out of scientific notation 7,890,000 → 7.89 \times 10^{6} (3 sig figs if original had 3 sig figs). 3.40\times10^{-5} → 0.0000340. Dimensional analysis multistep example (CH1 style) Problem: Convert 45.0 km/h to m/s. 1 km = 1000 m, 1 h = 3600 s. 45.0\ \text{km/h} \times \dfrac{1000\ \text{m}}{1\ \text{km}} \times \dfrac{1\ \text{h}}{3600\ \text{s}} = \dfrac{45.0\times1000}{3600}\ \text{m/s} = 12.5\ \text{m/s} (sig figs: 45.0 has 3 sig figs → answer 3 sig figs → 12.5 m/s). Given isotopic data — calculate average atomic mass (worked) (Neon example shown earlier; result 20.180 amu). Using periodic table data to find p, n, e and determine if atom or ion Problem: Given symbol: {}^{37}_{17}\text{Cl}^{-}. Protons = 17 (by atomic number). Mass number = 37 → neutrons = 37 − 17 = 20. Charge −1 → electrons = protons + 1 = 18. This is an anion (ion). Not a neutral atom. Lab hydrate calculations — general example (walkthrough) (We already did CuSO₄·5H₂O example; follow same steps for your lab values.) Density equation & rearrangements (reminder) \rho = \dfrac{m}{V},\qquad m=\rho V,\qquad V=\dfrac{m}{\rho}. Essay-style questions (short, clear answers + reasoning) 1) Classify a substance as element/compound/mixture, pure or mixture, molecules or ions (how to explain) Example substance: Table salt (NaCl) from a bag. Is it pure substance or mixture? If chemically pure NaCl sample → pure substance (compound). If table salt has additives (iodide, anti-caking agents), it’s a mixture. Element/compound? NaCl is a compound (sodium + chlorine chemically bonded). Molecules or ions? Ionic compound made of Na⁺ and Cl⁻ ions (not discrete molecules), so it consists of ions in a crystal lattice. Why: composition fixed for compound; ionic bonding indicates ions rather than molecules. 2) Explain why some elements form cations and others form anions (use noble gas concept) Atoms tend to reach a lower energy, more stable electron configuration. Many atoms achieve stability by adopting the electron configuration of the nearest noble gas: Metals (left side): have few valence electrons; losing them gives a noble gas configuration → form cations (positive). Nonmetals (right side): have more valence electrons but are short of an octet; gaining electrons gives a noble gas configuration → form anions (negative). Example: Na (1 valence electron) loses 1 → Na⁺ (like Ne). Cl (7 valence electrons) gains 1 → Cl⁻ (like Ar). 3) Describe J.J. Thomson and Rutherford experiments (short) Thomson: cathode ray deflection → discovered electrons → atom contains negative particles → plum pudding model. Rutherford: gold foil scattering → most of atom empty; tiny dense positive nucleus deflects alpha particles → nuclear model of atom. Worked examples you specifically asked (Example 1 & 2) Example 1: Using cations: Li⁺ and Ba²⁺; anions: O²⁻ and ClO₄⁻ (perchlorate). Create four neutral ionic compounds and explain subscripts. We want neutral compounds (total positive charge = total negative charge). Possible pairings: Li⁺ + O²⁻ → Li₂O. Reason: O²⁻ has −2, Li⁺ is +1. Need two Li⁺ to balance one O²⁻ → Li₂O. Ba²⁺ + O²⁻ → BaO. Reason: Ba²⁺ (+2) and O²⁻ (−2) already balance 1:1 → BaO. Li⁺ + ClO₄⁻ → LiClO₄. Reason: perchlorate has −1, Li⁺ has +1 → 1:1 ratio. Ba²⁺ + ClO₄⁻ → Ba(ClO₄)₂. Reason: Ba²⁺ (+2) needs two ClO₄⁻ to neutralize → use parentheses for two polyatomic anions. How subscripts determined: cross-balance charges to get net zero; the smallest whole-number ratio is used. Example 2: Write formula or name for each I’ll give the correct formula or name and a brief explanation. K₂S — Name: potassium sulfide. K⁺ and S²⁻ → need two K⁺ to balance one S²⁻. (NH₄)₂SO₄ — Name: ammonium sulfate. NH₄⁺ is +1; sulfate is SO₄²⁻ → need two ammonium to balance sulfate. OBr₂ — Name: oxygen dibromide? Wait — check elements: O + Br is unusual: oxygen normally forms −2, bromine usually −1; a neutral binary molecular compound OBr₂ would be better thought as dibromine monoxide? This is a tricky one. But the formula given is OBr₂; if treated as a binary molecular compound (two elements, both nonmetals), use prefixes: oxygen dibromide (but molecule uncommon). Important note: In practice, more common bromine-oxygen compounds have different formulas (e.g., BrO₂⁻ is chlorite analogs). For classwork, accept oxygen dibromide as name for OBr₂ (prefix naming: mono/di). If the intended was phosphorus triiodide etc., the list might have mixed types; follow molecular naming rules for two nonmetals. Na₂CO₃ · 10H₂O — Name: sodium carbonate decahydrate. Sodium carbonate with ten waters attached. Strontium phosphate — Formula: Sr₃(PO₄)₂. Strontium is Sr²⁺; phosphate is PO₄³⁻. LCM of 2 and 3 is 6 → need three Sr²⁺ (3×+2=+6) and two PO₄³⁻ (2×−3=−6). Gold(III) bromide — Formula: AuBr₃. Gold (III) = Au³⁺, bromide = Br⁻ → need three Br⁻ to neutralize. Beryllium sulfate tetrahydrate — Formula: BeSO₄·4H₂O. Beryllium is Be²⁺, sulfate SO₄²⁻ → BeSO₄, plus 4 waters. Phosphorous triiodide — Formula: PI₃. Binary molecular: phosphorus (P) + iodine (I) → prefixes: phosphorus triiodide. Aluminum hydroxide — Formula: Al(OH)₃. Al³⁺ and OH⁻ → need three OH⁻ to balance one Al³⁺

Inferior View of Skull, Mandible Removed

inferior view of the skull,mandible removed

Native Americans Organized by tribe. Geography influences culture for various groups. Northwest Coast Pacific ocean, whales, totem poles, log homes. Southwest Desert and canyons, cliff homes. Great Plains Buffalo, teepee homes made of animal hide. Eastern Woodland Long houses or other wood homes, Iroquois nation, 5 civilized tribes. Farmed the Three Sisters - beans, corn and squash. Animism Religious belief that there are spirits in inanimate objects (mountains, rivers, animals). Columbian Exchange Transfer of biological material (animals, plants and disease) between the New World and Europe during the age of exploration. Jamestown Settled by businessmen from England who sought to make money by growing and selling tobacco. Massachusetts Bay Settled by Puritans from England who were seeking religious freedom for themselves. New England Colonies Influenced by good harbors, abundant forests, rocky soil, and a short growing season. Middle Colonies Culturally diverse, bread-basket because of grain farming. Southern Colonies Provided agricultural products that were processed in the North and in Europe. Triangular Trade Led directly to the increased importation of enslaved Africans to the Western Hemisphere. Middle Passage The journey of slaves from Africa to the new world. British Mercantilism Economic policy used by the British in which the American Colonies served as a source of raw materials and a market to sell goods. French and Indian War Caused by disputed land claims in the Ohio River valley between the French and the British. Virginia House of Burgesses Early colonial efforts in self-government contributing to the development of representative democracy. Mayflower Compact Early colonial efforts in self-government contributing to the development of representative democracy. Town Hall Meetings Early colonial efforts in self-government contributing to the development of representative democracy. Albany Plan of Union Early attempt to unify American colonies but under British rule. Declaration of Independence States the colonial grievances against British rule and was written by Thomas Jefferson. John Locke's theory of natural rights Power to govern belongs to the people ('consent of the governed'). Bill of Rights Both documents support limitations on governmental power and stress the importance of individual liberty. NO TAXATION WITHOUT REPRESENTATION Many colonists believed they could not be taxed by the British because they had no representatives in the British government, which means that the British did not have the consent of the governed. Thomas Paine Published Common Sense which was influential in persuading American colonists to support colonial independence from Britain. Convinced many Americans who had been undecided about declaring independence from Britain. Response to Mercantilist Policies Committees of Correspondence/Non-importation Agreements/Boston Tea Party First Continental Congress. Sugar and Stamp Acts Tax foreign molasses and printed material. Quartering Act Requires colonists to house and feed British soldiers. Townshend Acts Taxes imported goods and tea. Boston Massacre Five people killed by British soldiers. Revolutionary War Begins shortly after the signing of the Declaration of Independence. American Colonies Win the war and independence with the help of familiar land and foreign aid from France. Mississippi River Became the western boundary of the U.S. at the end of the Revolutionary War. Articles of Confederation First form of government used by the U.S. after independence from Britain. The first plan of union for the original 13 states. Decentralized Political System Power is broken up and divided among many groups, not unified. Problems and Weaknesses of Articles Largely unsuccessful at solving many major problems because most powers remained with the state governments. Congress Depended on the states for men and money to support an army. The federal government could not enforce its laws. States' Powers Had the power to collect taxes, coin money, and control trade. Success of the Articles Provided a system for governing the Western territories and a process for admitting new states to the union. Constitutional Convention (1787) Major American delegates meet in Philadelphia to correct the weaknesses of the Articles of Confederation. Shays' Rebellion (1786) Significant because it convinced many Americans of the need for a stronger national government. Exposed the weaknesses of the Articles of Confederation. Bicameral Legislature Created a legislature with two houses that write and vote on laws. Three-Fifths Compromise Determined that 3/5 of the slave population would be counted for representation in the House. U.S. Constitution A statement of rules and procedures for governing the U.S. Sovereignty Derived from the consent of the governed (only the citizens give the government the power to rule). Democracy A government for the people by the people. A democracy must have citizen participation in government. Democratic Government A government characterized by a free and open election process. Republican Government A government in which representatives are elected by the people. Division of Power The concept included in the Constitution to prevent unlimited government power through federalism, checks & balances, and separation of powers. Federalism The division of powers between the national and state government. Legislative Branch The branch of government that includes Congress (House of Representatives and Senate) which proposes, writes, votes on laws, and approves treaties. Executive Branch The branch of government that includes the President of the U.S. and his cabinet. Judicial Branch The branch of government that includes federal courts and the Supreme Court. Marbury v. Madison A landmark case that established judicial review and strengthened the Judiciary branch of the U.S. Checks & Balances A system where each branch of government checks the others to ensure no one branch has too much power. Impeachment The process by which the President can be removed from office by trial conducted by Congress. Veto The power of the President to reject a bill passed by Congress. Override of Veto The process by which Congress can pass a bill despite a presidential veto, requiring a two-thirds vote of both houses. Elastic Clause A clause that allows Congress to pass laws necessary and proper to fulfill its duties, broadening its power. Judicial Review The power of the courts to declare laws unconstitutional. Electoral College The body that elects the President of the U.S. based on electoral votes from each state, not a popular vote. George Washington The first President of the U.S. who set precedents for future presidents and issued the Proclamation of Neutrality. Whiskey Rebellion A rebellion in western Pennsylvania against a new excise tax, which Washington suppressed using state militia. Farewell Address A speech by Washington urging the U.S. to avoid European conflicts and alliances. Louisiana Purchase (1803) The acquisition of the Louisiana Territory by Thomas Jefferson, which contradicted his strict interpretation of the Constitution. Mississippi River Control The goal of the Louisiana Purchase to secure U.S. control of the Mississippi River for trade. Ohio River Valley The region whose farmers gained the greatest economic benefit from the Louisiana Purchase. Westward Expansion The focus of the U.S. following the Louisiana Purchase, promoting settlement and development of western territories. Articles of Confederation The first constitution of the United States, which established a weak federal government. Washington's Precedents The traditions and practices established by George Washington during his presidency. Constitutional Convention The 1787 meeting in Philadelphia where the U.S. Constitution was created. Shays Rebellion An armed uprising in 1786-1787 by farmers in Massachusetts protesting economic injustices. US Constitution The supreme law of the United States, establishing the framework of government. Great Compromise The agreement that established a bicameral legislature in the U.S. Congress; Settled a dispute over state representation in national Congress. ⅗ compromise The agreement that slaves would count as three-fifths of a person for representation purposes. Commerce Compromise The agreement that allowed Congress to regulate commerce but prohibited export taxes. Bill of Rights The first ten amendments to the U.S. Constitution that guarantee individual liberties. Federalists/Antifederalists Federalists supported the Constitution; Antifederalists opposed it, fearing too much central power. 3 branches of government The division of government into the legislative, executive, and judicial branches. Checks and Balances A system that ensures no one branch of government becomes too powerful. Louisiana Purchase The 1803 acquisition of territory from France that doubled the size of the United States. Loose/strict constructionists Loose constructionists interpret the Constitution broadly; strict constructionists interpret it narrowly. Indian Removal The policy of relocating Native American tribes to lands west of the Mississippi River. Civilization The process of assimilating Native Americans into American culture. Trail of Tears The forced relocation of Native Americans from their homelands, resulting in thousands of deaths. Worcester v. Georgia A Supreme Court case that ruled in favor of Native Americans but was not enforced by Jackson. Andrew Jackson The seventh President of the United States known for his populist policies and Indian removal. Manifest Destiny The belief that the U.S. was destined to expand across the North American continent. Cotton Gin A machine that quickly and efficiently removes seeds from cotton fibers. Missouri Compromise An agreement passed in 1820 that allowed Missouri to enter the Union as a slave state and Maine as a free state. Compromise of 1850 A package of five separate bills passed by the United States Congress to defuse a political confrontation between slave and free states. Abolitionists Individuals who advocated for the immediate end of slavery in the United States. Kansas Nebraska Act A law that allowed voters in Kansas and Nebraska to choose whether to allow slavery, effectively repealing the Missouri Compromise. Dred Scott v Sanford An 1857 Supreme Court case that ruled that African Americans could not be American citizens and that Congress had no authority to prohibit slavery in federal territories. Bleeding Kansas A series of violent political confrontations in the United States involving anti-slavery and pro-slavery elements in Kansas. Uncle Tom's Cabin An anti-slavery novel by Harriet Beecher Stowe published in 1852 that depicted the harsh realities of slavery. Underground Railroad A network of secret routes and safe houses used by enslaved African Americans to escape to free states and Canada. Horace Mann An American educational reformer who promoted public education and is known as the 'Father of the American Public School System.' Seneca Falls Convention The first women's rights convention held in 1848, which launched the women's suffrage movement in the United States. 2nd Great Awakening A Protestant religious revival during the early 19th century in the United States that emphasized individual piety and a personal relationship with God. Temperance A social movement against the consumption of alcoholic beverages. Civil War A conflict from 1861 to 1865 between the Northern states (Union) and Southern states (Confederate States) over issues including states' rights and slavery. Abraham Lincoln The 16th President of the United States who led the country during the Civil War and worked to end slavery. Emancipation Proclamation An executive order issued by Abraham Lincoln in 1862 that declared the freedom of all slaves in Confederate-held territory. Reasons for North (Union) Victory The North was better prepared economically, had more human resources, and superior war material. Reconstruction Era The period following the Civil War during which the Southern states were reorganized and reintegrated into the Union. Lincoln's Plan for Reconstruction Aimed to restore Southern representation in Congress and offered amnesty to Confederates who swore allegiance to the U.S. Radical Republicans A faction of the Republican Party that sought to impose harsh penalties on the Southern states and promote civil rights for freed slaves. Andrew Johnson The 17th President of the United States who succeeded Abraham Lincoln and oversaw the early years of Reconstruction. Reconstruction A policy supported by Lincoln to allow Southern States to reenter the nation as quickly as possible. Radical Republicans Members of Congress who disagreed with Johnson about how to handle Reconstruction, leading to Johnson's impeachment. Impeachment of Johnson Johnson was impeached for firing Secretary of War Edwin M. Stanton without Senate approval, but the impeachment failed. 13th Amendment Law that formally abolished slavery in the U.S. in 1865. 14th Amendment Law that officially gave citizenship to African Americans and legally protected them under the Bill of Rights and U.S. Constitution. 15th Amendment Law that granted African Americans voting rights. Poll Taxes Fees collected by Southern States to restrict African Americans from exercising their voting rights. Literacy Tests Requirements imposed by Southern States to limit African Americans' voting rights. Jim Crow Laws Laws enacted in the 1870s and 1880s to restrict the freedoms of African Americans after the Civil War. Plessy v. Ferguson Supreme Court case in 1896 that upheld Jim Crow Laws based on 'separate but equal' public facilities for African Americans. Black Codes Laws aimed at restricting the rights of former slaves and limiting the effectiveness of the 14th and 15th amendments. Ku Klux Klan Group that attempted to restrict the rights of former slaves. Sharecropping System of farming in Southern States after the Civil War that kept former slaves economically dependent on farms. New South Term describing changes in the Southern economy, including industrial development and agricultural diversification. Sectionalism The division between the North and South that contributed to tensions leading up to the Civil War. Gilded Age Period marked by economic growth and industrialization in the U.S. Industrial Revolution Causes Factors such as capital, labor supply, Erie Canal, and transcontinental railroads that contributed to industrial growth. Mechanization of Agriculture The use of machines in farming that led to an increase in production. Effects of Industrial Revolution Challenges for smaller industries, development of monopolies, widening economic gap, and increased immigration. Social Darwinism Theory which believed that the growth of large business at the expense of others was merely survival of the fittest (the stronger businesses will succeed and the weaker one will fail). Laissez-faire Capitalism Economic policy which argues that government should limit any interference in the economy (the government should leave the economy alone). Rise of Big Business (1865-1900) Federal Government followed laissez-faire economic policy. Trusts and monopolies were created by entrepreneurs to maintain control of the market. Robber Baron Term used during the Gilded Age to characterize leaders of big business who used ruthless tactics when dealing with competitors. Gilded Age Mark Twain labeled the late 1800's ________ to describe the extremes of wealth and poverty (big differences between the rich and the poor). Urbanization Rural (countryside) residents move to urban (inner city) areas in search of jobs. Size of cities increase. How the Other Half Lives Book by Jacob Riis that exposed the living conditions of urban slums (working-class, inner-city neighborhoods). Working Conditions Rapid industrial growth leads to shift from rural to urban lifestyle, widespread use of child labor, and growth of tenements & slums. Immigration Many immigrants traveling to the U.S. settled in urban areas in the North because rapid industrialization created many job opportunities. New Immigrants Came primarily from southern and eastern Europe (Ex: Italy & Russia) between 1890-1915. Were culturally different from the earlier immigrants. Chinese Exclusion Act (1882) Limited the number of Chinese immigrants entering the U.S. An example of Nativism. Nativists Group of Americans who were angry about Immigrants taking jobs from Americans and working for cheaper wages. Trust Titans Business leaders who controlled large monopolies and trusts. Philanthropy The desire to promote the welfare of others, expressed especially by the donation of money to good causes. Gospel of Wealth Philosophy that wealthy individuals have a responsibility to use their wealth for the greater good of society. Industrial Revolution Period of major industrialization that took place during the late 18th and early 19th centuries. Monopolies/trusts Entities that dominate a market and restrict competition. Gentlemen's Agreement Informal agreement between the U.S. and Japan that restricted Japanese immigration. America Expands Between the 1890's and the start of World War I (1914), the U.S. expanded its access to overseas markets and raw materials through the policy of imperialism. Reasons for Imperialism Due to the expansion of American industry during the 1800's, the U.S. needed to obtain raw materials and new markets. Dollar Diplomacy Attempted to increase the U.S. power in Latin America, indicating a U.S. desire to interact with foreign countries in ways that were profitable to U.S. corporations. Economic Nationalism U.S. practices economic nationalism by implementing protective tariffs to help American industry. Protective Tariff A tax on foreign products making them more expensive so people will buy American products instead. Open Door Policy (1899-1900) Issued in order to secure equal trade opportunities in China and guarantee access to its markets. Annexation of Hawaii U.S. annexes (takes over) Hawaii and the Philippines. Spanish American War A conflict in 1898 that resulted in the U.S. obtaining overseas colonies and being recognized as a world power. Yellow Journalism Joseph Pulitzer and William Randolph Hearst used yellow journalism to generate public support for the Spanish American War. Panama Canal Built as a result of the Spanish American War to allow quicker movement between oceans for trade and military security. Progressive Movement A movement to correct the economic and social abuses of industrial society, supporting consumer protection, women's suffrage, and other reforms. Progressives Believed the government needs to regulate big business to protect consumers and workers, opposing the Laissez-faire attitude. Jane Adams A prominent social reformer and activist during progressive era, who established settlement houses that provided assistance to the poor. W.E.B. Du Bois Formed the National Association for the Advancement of Colored People (NAACP) to end segregation and win equal rights. Booker T. Washington Believed that African Americans should pursue education as the key to improving social status and founded a vocational training institution. Labor Union An organization of employees formed to bargain with the employer for better working conditions, benefits, and pay. Clayton Antitrust Act Made unions legal, allowing them to organize and improve conditions. Collective Bargaining Discussions between labor union leaders and management to agree on a contract for workers. Wagner Act (1935) Legalized collective bargaining. Triangle Shirtwaist Company Fire A tragedy where many women workers were killed in a factory fire, drawing national attention to worker safety. Samuel Gompers The person who founded the AFL; Organized workers into unions to strive for better conditions and pay. American Federation of Labor The first long-lasting, successful labor union in the U.S., focusing on the rights of skilled workers. Pure Food & Drug Act (1906) Law that provided federal inspection of meat products and forbade unsafe food products and poisonous medicines. Meat Inspection Act Created sanitary standards established for slaughterhouses and meat processing plants. Muckraker Writers during the progressive era that exposed social ills of inner cities, factory conditions, and political corruption. The Jungle A publication by Upton Sinclair that led Congress to pass the Meat Inspection Act. Upton Sinclair An author known for his muckraking work, particularly The Jungle. Ida M Tarbell A muckraker who focused on issues including the monopoly of Standard Oil. Lincoln Steffens A muckraker who exposed political corruption in cities. Jacob Riis A muckraker known for his work How the Other Half Lives. Booker T Washington An African American educator and leader who advocated for vocational training. WEB Dubois An African American sociologist and civil rights activist who co-founded the NAACP. Nativism A political policy favoring the interests of established inhabitants over those of immigrants. Labor Unions Organizations formed by workers to advocate for better working conditions and wages. Collective bargaining The negotiation process between employers and a group of employees aimed at reaching agreements. Triangle Shirtwaist Fire A tragic industrial disaster that highlighted the need for better workplace safety regulations. AFL The American Federation of Labor, a national federation of labor unions in the United States. Plessy v Fergusun A landmark Supreme Court case that upheld racial segregation under the 'separate but equal' doctrine. Woodrow Wilson The 28th President of the United States who led the nation during World War I. Neutrality A policy of not taking sides in a conflict, adopted by Wilson at the beginning of World War I. Unrestricted submarine warfare A type of naval warfare in which submarines sink vessels without warning. Espionage Act A law enacted in 1917 to prohibit interference with military operations or support for U.S. enemies. Sedition Act A law that made it a crime to criticize the government during World War I. Schenck v. U.S. A Supreme Court case that ruled that freedom of speech could be limited during wartime. Fourteen Points A statement of principles proposed by President Wilson to govern the postwar world. League of Nations An international organization established after World War I to promote peace and cooperation. Isolationism A foreign policy of avoiding involvement in international conflicts, followed by the U.S. in the 1920s and 30s. Treaty of Versailles Congress refuses to sign the Treaty of Versailles because many Senators objected to the U.S. membership in the League of Nations, fearing that it would pull the U.S. into another major war. Washington Naval Conferences Attempts by the U.S. to achieve peace and arms control in the decade after WWI. Kellog-Briand Pact Attempts by the U.S. to achieve peace and arms control in the decade after WWI. Bolshevik Revolution Communist takeover of Russia in 1917 increased nativism leading to the Red Scare (fear of Communism in the U.S. following WWI). Immigration quota acts of 1921 & 1924 Restricted the number of immigrants from Southern and Eastern Europe due to a recurrence of nativist attitudes following WWI. 19th Amendment Women were granted the right to vote during the Progressive Era (1917). Women's suffrage The national effort to ratify women's suffrage was strengthened by the economic opportunities created by World War I. Major female leaders of the women's rights movement Susan B. Anthony, Carrie Chapman Catt, Elizabeth Cady Stanton, and Lucretia Mott. Roaring Twenties The 1920's are called the 'Roaring Twenties' because of widespread social and economic change and changing cultural values. Prohibition Law authorized by the 18th Amendment that banned the manufacture and sale of alcoholic beverages. Sacco and Vanzetti Two immigrant anarchists who were convicted of murder and executed with very little evidence during the height of the Red Scare. Scopes Trial John Scopes was convicted in 1925 for teaching about evolution, illustrating a conflict concerning religious beliefs and scientific theories. Harlem Renaissance African American authors and artists used literature and art to celebrate the richness of their heritage. Flappers Women during the 1920's that rejected traditional feminine roles and refused to conform to society's expectations. Henry Ford Use of the assembly line in the production of automobiles led directly to a decrease in the cost of automobiles. Economic growth during the 1920's Development of many new consumer goods led to rapid economic growth. Automobiles, radio, and motion pictures Standardized American culture and influenced what people considered to be 'American culture'. Red Scare A period of intense fear of Communism in the U.S. following WWI. Cultural conflict in the 1920s Illustrated by the Scopes Trial and the Harlem Renaissance, reflecting tensions between traditional values and modern ideas. Consumer Culture Emergence of a culture where buying is encouraged by advertising and installment payments. Installment Buying Paying for something a little at a time rather than all at once. Stock Speculation Heavy increases in stock investments driven by a belief in never-ending prosperity. Government's Role in the Economy (1920s) Prevailing view that the government should interfere as little as possible. Warren G. Harding President who called for 'a return to normalcy' and advocated for reduced international involvement and less government regulation of business. Calvin Coolidge President who believed the economy functions best if government allows business to operate freely. Overproduction of Farm Crops Demand for American farm goods dropped dramatically during the 1920s due to decreased European need for imports. Dust Bowl Environmental disaster caused by over-farming and severe drought, leading to increased westward migration. Stock Market Crash of 1929 Considered the start of the Great Depression, largely caused by speculators buying stocks on margin. Decline in Farm Prosperity A significant decrease in the economic well-being of farmers during the Great Depression. Overproduction and Underconsumption Situation where U.S. businesses produced more products than the population could buy, leading to low consumer demand. Global Financial Interdependence Evidence that economies worldwide are interconnected; if one falls, they all fall. Herbert Hoover President of the U.S. at the start of the Great Depression, whose policies favored big business. Hoovervilles Nickname for poor communities due to Hoover's refusal to provide direct federal aid to the homeless. Bonus Army WWI veterans who marched on Washington demanding payment for their services. Franklin Delano Roosevelt (FDR) President who won an easy victory over Hoover in 1932, advocating for government intervention in economic problems. Court Packing FDR's proposal to increase the size of the Supreme Court to make it favorable to New Deal laws. Deficit Spending Used by FDR to stimulate economic growth. FDR Reelected to 3rd Term Controversial event in 1940 as it challenged the tradition of presidents stepping down after two terms. FDR's reelection to 3rd term Eventually led to the establishment of presidential term limits. New Deal Most immediate goal was to provide work for the unemployed. Public works jobs Tried to stimulate economic recovery by creating public works jobs. Social welfare programs Were expanded during the New Deal. Government involvement Increased government involvement with both business and labor. Agricultural Adjustment Acts Designed to increase prices of farm products by reducing farm output. Tennessee Valley Authority (TVA) Created in 1933 to improve economic conditions in a poor rural region. Social Security Act 1935 Considered an important program because it extended support to elderly/retired citizens. Federal Deposit Insurance Corporation (FDIC) Tried to restore public confidence in banks by safeguarding savings. Bank holiday (1933) Declared to restore confidence in the nation's banks. WPA Intended to help unemployed workers. Civilian Conservation Corps (CCC) Intended to help unemployed workers. National Labor Relations Act (Wagner Act) Strengthened labor unions by legalizing collective bargaining. Opposition to New Deal The strongest opposition came from business leaders. Laissez-Faire The tradition that government shouldn't interfere with the economy. Critics of the New Deal Claimed the TVA and Social Security System threatened the U.S. economy by applying socialist principles. Impact of New Deal Raised national debt and expanded the power of the Federal Government. Political thinking change Supported the idea that the government should become more involved in the social and economic life of the people. WWII start Started when Germany invaded Poland in 1939. U.S. Neutrality In the 1930's, the primary objective was to avoid involvement in Asian and European conflicts. Neutrality Acts Passed in mid 1930's to avoid mistakes that led to WWI. Lend-Lease Act Efforts to help the Allies without formally declaring war. Bombing of Pearl Harbor Brought the U.S. directly into World War II. Totalitarian aggression The U.S. became involved to fight totalitarian aggression from Germany, Italy, and Japan. D-Day Invasion June 1944- Important to the outcome of WWII because it opened a new Allied front in Europe (Germany had to fight enemies from the East and West instead of just the East). Key challenge faced by the U.S. during WWII Fighting the war on several fronts (Europe and Asia). U.S. and Soviet Union cooperation during WWII Supports the idea that alliances are built upon mutual self-interest (the U.S. and Soviet Union were enemies but formed an alliance because they were both enemies with Germany). 1944 election of FDR Can be attributed to the unwillingness of voters to change leadership during a major crisis. FDR's personal diplomacy during WWII Strengthened the President's role in shaping U.S. foreign policy. Women in wartime industries Women replaced men in essential wartime industries. Economic opportunities for women during WWII Expanded for women. Post-war job situation for women Many working women left their factory jobs because they were forced to give up their jobs to returning war veterans. Migration of African Americans during WWII More African Americans migrated to large cities because industry was expanding. GI Bill (1944) Extended educational and housing opportunities to war veterans. Provided federal funds for veterans to attend college. Rationing during WWII Ordered by the U.S. government to conserve raw materials for the war effort. Funding WWII The U.S. government relied heavily on the sale of war bonds (lends from citizens to help fund the war. Also contributed to the national debt). Economic impact of WWII on the U.S. Accelerated its recovery from the Great Depression. Korematsu v. U.S. The U.S. government considered Japanese Americans a threat to national security during WWII, causing them to place Japanese Americans in confinement in internment camps. Supreme Court ruling on Japanese internment Said that the removal of Japanese Americans from their homes was constitutional because this type of action was necessary during a national emergency. Wartime conditions and civil liberties Supreme Court ruled that wartime conditions justified limitations being placed on civil liberties. Impact of WWII on Japanese Americans Many Japanese lost their homes and businesses. President Harry Truman's decision on atomic bombs Decided to drop atomic bombs on Japan (Hiroshima & Nagasaki). Truman's use of atomic weapons Decided to use atomic weapons against Japan in order to end the war while limiting the loss of American lives. Truman's impact on civil rights Advanced the cause of civil rights for African Americans by ordering the desegregation of the Armed Forces (Black and White troops fight together and are no longer separated). Truman Doctrine Originally designed to contain communism by giving aid to Greece and Turkey (later expanded by Eisenhower). Truman and General MacArthur Relieved General Douglas MacArthur of his command in the Korean conflict because General MacArthur challenged the concept of civilian control over the military. Loyalty checks during Truman's presidency Required loyalty checks due to the fear of communist influence in government. Nuremberg Trials Held to make German leaders accountable for the Holocaust (mass genocide against Jews and other minorities). Established the principle that leaders of a nation may be held accountable (put on trial) for crimes against humanity/ war crimes. United Nations Replaced the League of Nations in order to prevent international disputes from escalating into major wars. Marshall Plan (1948-1952) U.S. provided economic aid in order to help Europe's economic recovery after WWII. U.S. foreign policy after WWII Changed as the U.S. became more involved in world affairs. Eleanor Roosevelt's contribution Helped create the United Nations Universal Declaration of Human Rights. Post-WWII economic growth In the decade after WWII, rapid growth in personal income contributed to the expansion of the middle class. Appeasement A diplomatic policy aimed at avoiding conflict by making concessions to an aggressor. African Americans in WW2 Refers to the contributions and experiences of African Americans during World War II. Rosie the Riveter A cultural icon representing women who worked in factories and shipyards during World War II; used as a poster in order to recruit women Japanese Internment The forced relocation and incarceration of Japanese Americans during World War II. Rationing The controlled distribution of scarce resources, goods, or services during wartime. Pearl Harbor The site of the surprise military attack by the Japanese on December 7, 1941, leading the U.S. to enter WWII. War Bonds Debt securities issued by a government to finance military operations during times of war. Manhattan Project A secret U.S. project during World War II that developed the first nuclear weapons. Desegregation of the Military The process of eliminating racial segregation within the United States Armed Forces. United Nations (UN) An international organization founded in 1945 to promote peace, security, and cooperation among countries. Selective Service The system by which men are registered for military conscription in the United States. Lend Lease A U.S. program during WWII that supplied Allied nations with vast amounts of war material. NATO North Atlantic Treaty Organization, a military alliance formed in 1949 for mutual defense against aggression. Cold War An era of political tension and military rivalry between the U.S. and Soviet Union from 1946 to 1989. Baby Boom A significant increase in the birth rate following WWII, particularly in the 1950s and 1960s. Iron Curtain The boundary dividing Europe into two separate areas of political influence during the Cold War. Sputnik Launch The 1957 launch of the first artificial satellite by the Soviet Union, marking the start of the space race. Containment A U.S. policy aimed at preventing the spread of communism during the Cold War. Berlin Airlift The U.S. operation to supply West Berlin after the Soviet blockade in 1948-1949. McCarthy Era A period of intense anti-communist suspicion in the U.S. during the early 1950s. Senator Joseph McCarthy A U.S. senator known for leading the anti-communist witch hunts during the McCarthy Era. McCarthyism The practice of making accusations of subversion or treason without proper evidence. Korean War A conflict from 1950 to 1953 between Communist North Korea and South Korea, supported by the U.S. and UN. United Nations military force First time the United Nations used military force to oppose aggression. General Douglas MacArthur Relieved of command in the Korean War for threatening civilian control of the military. Presidential wartime powers Expanded during the Korean War. Outcome of the Korean War Korea continued to be a divided nation. Vietnam War Civil war between Communist North Vietnam and U.S.-backed South Vietnam. Domino Theory Idea that if one country falls to communism, others around it will as well. Vietnam War protests Significant protests in the U.S. including Berkeley demonstrations and Kent State protest. 26th Amendment Lowered the voting age to 18 as a result of U.S. participation in the Vietnam War. War Powers Act 1973 Limited the president's ability to send troops into combat abroad. Public opinion on foreign policy Showed that foreign policy can be altered by public opinion. Trust in government Greater public distrust of governmental policies post-Vietnam War. Military technology and victory U.S. experience in the Vietnam War showed that superior military technology does not guarantee victory. Peace Corps Established by President John F. Kennedy to support developing nations. Bay of Pigs Invasion 1961 Kennedy's effort to remove Fidel Castro from power in Cuba, considered his most significant foreign policy failure. Cuban Missile Crisis 1962 Soviet Union placed nuclear weapons in Cuba; Kennedy imposed a naval blockade. Nuclear Test Ban Treaty Negotiated by Kennedy to limit nuclear testing following the Cuban Missile Crisis. New Frontier Kennedy's program that expanded the U.S. space program. Détente Policy to ease tensions between the U.S. and Soviet Union. Strategic Arms Limitations Talks (SALT) Part of the presidential policy of détente aimed at reducing world tensions. Nixon's visit to China 1972 Attempt to reduce tensions between the U.S. and Communist China. Watergate Scandal Break-in at the Democratic National Committee headquarters leading to Nixon's resignation. Trust in elected officials Undermined as a lasting effect of the Watergate scandal. Executive privilege Weakened as a result of the Watergate scandal. Nixon (1974) Supreme Court case that directly limited the president's power of executive. Civil Rights Movement Movement to end segregation based on race during the 1960's. Civil Disobedience Nonviolent attempts to oppose segregation, such as lunch counter sit-ins and freedom riders. Jackie Robinson Broke color barrier in Major League Baseball. President Truman's Executive Order Desegregated armed forces. NAACP National Association for the Advancement of Colored People, focused on higher education, full political participation, and continued support for civil rights. Brown v. Board of Education of Topeka Required the integration (desegregation) of all public schools in the U.S. and overturned Plessy v. Ferguson ruling. Eisenhower's Federal Troops Sent into Little Rock, Arkansas in 1957 to enforce a Supreme Court decision to desegregate public schools. Martin Luther King Jr. Leader of the civil rights movement during the 1960's, advocated for nonviolent protest. Malcolm X Civil rights leader during 1950's and 60's that advocated black separatism. Rosa Parks Practiced civil disobedience by refusing to give up her seat on a bus to a white man in Montgomery, Alabama. Civil Rights Act 1964 Passed to correct racial and gender discrimination and ended Jim Crow laws. Voting Rights Act 1965 Removed the literacy test as a voting qualification to eliminate racial barriers within voting. Affirmative Action Programs Main goal is to promote economic gains for minorities and women. Fair Housing Act Government efforts to end discrimination against various groups. Americans with Disabilities Act Government efforts to end discrimination against individuals with disabilities. Chief Justice Earl Warren Followed a policy of judicial activism and expanded individual rights in criminal cases. Supply-Side Economics Lowered tax rates on personal and business income and supported economic changes favoring big business. Trickle Down Economics Believed that economic growth depends on making increased amounts of capital available to business. National Debt in the 1980s Increased greatly due to the Federal Government's reliance on deficit spending. Reagan's Federal Budget Proposals Came under criticism for including very large deficits. Involvement in World Affairs in the 1980s Based on a concern for advancing the nation's self-interest. North American Free Trade Agreement (NAFTA) Increased commerce and eliminated tariffs. Encouraged countries to participate in the global economy. Reflected the U.S. commitment to globalization. Persian Gulf War A direct result was that the U.S. liberated Kuwait from Iraqi control. Election of 2000 George Bush won even though Al Gore received more popular votes, because of the way the Electoral College votes came out. USA Patriot Act Increased government surveillance of citizens, increased cooperation between law enforcement and intelligence. War on Terror War in Afghanistan against Taliban and Al Qaeda. War in Iraq Saddam Hussein accused of having WMD's and wouldn't allow inspection. Barrack Obama First African-American elected to the Presidency. Obamacare Passed major health insurance reform package. September 11, 2001 terrorist attacks Attacks on World Trade Center and the Pentagon. Rise of the Tea Party Extreme right wing conservatives opposed to most government spending. Supply-side economics Economic theory that advocates reducing taxes and decreasing regulation to stimulate economic growth. George Bush Committed U.S. troops to the Persian Gulf War to assure the flow of Middle East oil to the U.S. and its allies. Bill Clinton Supported NAFTA because it would stimulate economic growth in the U.S. U.S. troops in Haiti and Bosnia Sent during the 1990's to stop conflicts within those nations. Bombing of Kosovo Participated in 1999 because of human rights violations. Economic stimulus package Passed by Barrack Obama to prop up the economy. Withdrawal of American troops Began from Iraq and Afghanistan under Barrack Obama. Mission to find Osama bin Laden Ordered by Barrack Obama that resulted in the killing of Al Qaeda leader.

Dependant/ independent variables Independent- The variable being manipulated Dependant- The observed result of the independent variable being manipulated 3 Domains Prokaryotes, Eukaryotes, Archae 3 Types of Relationships Commensalism Parasitism Mutualism Scientific Hypothesis an idea that proposes a tentative explanation about a phenomenon or a narrow set of phenomena observed in the natural world. Difference between Archea/ Bacteria Archaea consists of three RNA whereas bacteria consists of single RNA. Quantitative/ Qualitative data Quantitative data is numbers-based, countable, or measurable Qualitative data is interpretation-based, descriptive, and related to language. Homeostasis Balance of the body Controlled Experiment In a controlled experiment, all extraneous variables are held constant so that they can't influence the results. Difference between Hydrophobic/ Hydrophilic Any substance that repels water Any substance that has an affinity for water Protons/ electrons/ neutron Protons- a subatomic particle with a positive electric charge Electrons- a negatively charged subatomic particle that can be either bound to an atom or free (not bound). Neutron- an uncharged atomic particle that has a mass nearly equal to that of the proton and is present in all known atomic nuclei except the hydrogen nucleus What a cation/ Anion Cations are ions that are positively charged. Anions are ions that are negatively charged. Isomers Chemical compounds that have identical chemical formulae but differ in properties and the arrangement of atoms in the molecule Picture of elements/ what's on valence electrons Valence electrons have negatively charged particles How many valence electrons are in shells 8 electrons What are examples of trace elements? zinc (Zn), copper (Cu), selenium (Se), chromium (Cr), cobalt (Co), iodine (I), manganese (Mn), and molybdenum (Mo). Different types of Bonds Covalent Bonds- one or more electrons shared between atoms Non-polar covalent: electrons are shared equally between nuclei Polar covalent- electrons shared equally between the nuclei Ionic Bonds- one or more electrons transformed from one to another Hydrogen Bonds- a weak bond between a partially positive hydrogen atom and a partially negative oxygen atom Cohesion/ Adhesion Cohesion- the attraction of molecules for other molecules of the same kind Adhesion- the sticking of molecules or surfaces to each other Radioactive Isotopes, Why are they used Radioisotopes are an essential part of medical diagnostic procedures. In combination with imaging devices that register the gamma rays emitted from within, they can be used for imaging to study the dynamic processes taking place in various parts of the body. Why is Water Important Water's role as a solvent helps cells transport and use substances like oxygen or nutrients. Properties of Water Water is polar Water is a solvent Water is less dense as a solid than a liquid What are reactions a process that converts one or more substances to another substance. .Why are trace elements important? function primarily as catalysts in enzyme systems What are Buffers Substances in the cells that help maintain a relatively stable pH What is the pH scale? a measure of how acidic/basic water is Find the molecular mass of something Atomic weight on the periodic table is equal to moles #/1m = x/ desired # moles Functional groups The shape of molecules directly affects their function Types of atoms, bonds A specific arrangement of atoms Difference between Hydraullisis/ Dehydration Dehydration- removes a water molecule from a new bond Hydrolysis- add a water molecule, breaking a bond Differentiate between Polymers/ Monomers A monomer is a molecule with low molecular weight that can combine with others of the same kind to form a chemical compound known as a polymer Different types of Proteins/ enzymes antibodies, contractile proteins, enzymes, hormonal proteins, structural proteins, storage proteins, and transport proteins Difference between plants and animals Plants are not mobile and animals are Cell membrane components Phospholipids, cholesterol, glycolipids, lipid bilayer, membrane proteins

2.3: Detect, Remove, and Prevent Malware

📘 Chapter 19: Blood – Full Simplified Study Notes (27 Slides) ⸻ Slide 1: Cardiovascular System • Cardiovascular system = heart, blood, blood vessels. • Blood’s job: • Delivers nutrients, hormones, oxygen, and chemical messages. • Carries immune cells to fight infections. • Why it matters: Without this transport system, cells would starve and toxins would build up. • Analogy: Like UPS + garbage service → delivers packages (nutrients, O₂) and removes trash (waste, CO₂). ⸻ Slide 2: Whole Blood • Whole blood = plasma + formed elements. • Hematocrit: percentage of blood volume made of cells. • Plasma: watery fluid. • Key properties of blood: • Temp: 38°C (100.4°F) → warmer than body surface. • Thickness: 5x thicker than water. • pH: ~7.4 (slightly alkaline). • Volume: Men = 5–6 L, Women = 4–5 L. • About 7% of body weight. • Example: If someone weighs 150 lbs, about 10 lbs of that is blood. ⸻ Slide 3: Blood Plasma • Plasma = liquid with proteins + solutes. • Proteins: • Albumins: keep water inside blood vessels (prevent swelling). • Globulins: antibodies → defense. • Fibrinogen: forms clots. • Other solutes: • Electrolytes: Na⁺, K⁺, Cl⁻, HCO₃⁻ (important for nerves/muscles). • Nutrients: glucose, fructose, amino acids. • Wastes: urea, uric acid. • Analogy: Plasma = soup broth carrying salt, sugar, proteins, and waste. ⸻ Slide 4: Formed Elements • Red Blood Cells (RBCs / erythrocytes): 99.9% of all blood cells. • RBC count: Men = 4.5–6.3 million/μL, Women = 4.2–5.5 million/μL. • Platelets: fragments needed for clotting. • White Blood Cells (WBCs / leukocytes): fight disease. • Think: Plasma is the liquid, formed elements are the “stuff floating inside.” ⸻ Slide 5: RBC Structure • RBCs lose their nucleus & organelles. • Consequences: • Can’t divide. • Can’t make proteins or repair. • Only use glycolysis (anaerobic metabolism) → no oxygen needed for energy. • Analogy: Like delivery trucks with no engine shop → they drive until they break down. ⸻ Slide 6: RBC Lifespan • RBCs have no nucleus, mitochondria, ribosomes → no repair. • Rely on glycolysis for energy. • Live about 120 days. • Must be recycled by spleen/liver. • Example: Like a disposable battery that runs until it dies. ⸻ Slide 7: RBC Shape & Function • Shape = biconcave disc (doughnut-like, thin middle). • Benefits: • High surface area → better oxygen exchange. • Can stack like coins → smooth flow. • Flexible → squeeze through tiny capillaries. • Analogy: Like a flexible frisbee that can bend and stack. ⸻ Slide 8: Hemoglobin • Main protein inside RBC. • Structure: • 2 alpha chains + 2 beta chains. • Each has heme group with iron atom (Fe). • Function: Iron binds oxygen → carries it around body. • Why recycle? Iron is valuable, so old RBCs get broken down to save it. • Analogy: Hemoglobin = oxygen backpack. ⸻ Slide 9: RBC Lifecycle • Starts from hemocytoblast (stem cell). • Branches into: • Myeloid stem cells: make RBCs + some WBCs. • Lymphoid stem cells: make lymphocytes. • Think: Hemocytoblast = tree trunk, RBCs and WBCs = branches. ⸻ Slide 10: RBC Production (Erythropoiesis) • Erythropoiesis = making RBCs. • Embryo: 1st 8 weeks = yolk sac → later liver, spleen, thymus, bone marrow. • Adult: red bone marrow only (vertebrae, sternum, ribs, skull, pelvis, ends of long bones). • Nutrients needed: amino acids, iron, vitamins B12, B6, folic acid. • Analogy: RBCs = cookies, bone marrow = kitchen, iron + vitamins = ingredients. ⸻ Slide 11: RBC Production Control • Controlled by erythropoietin (EPO). • Made by kidneys/liver when low oxygen (hypoxia). • Effects: • Increases stem cell division. • Speeds up hemoglobin production. • Blood doping: Athletes take EPO or reinfuse RBCs → more oxygen for muscles. • Risk: thicker blood → clots, strokes. • Analogy: EPO = coach yelling “make more RBCs!” ⸻ Slide 12: Blood Types • RBCs have antigens on membranes (A, B, AB, O). • Rh factor = + or –. • Plasma has antibodies (agglutinins): attack foreign antigens → cause clumping (agglutination). • Universal donor = O–. • Analogy: Blood type = ID card. If ID doesn’t match, antibodies attack. ⸻ Slide 13: RBC Summary • Know: • How typing works. • How RBCs are made. • What controls them. • Why they live 120 days. • How they’re broken down. • Analogy: RBCs = delivery trucks with expiration dates. ⸻ Slide 14: WBC Basics • WBCs = leukocytes. • Have nuclei, organelles, no Hb. • Functions: fight pathogens, remove wastes, destroy abnormal cells. • Only in blood briefly → then move into tissues. • Analogy: WBCs = body’s police force. ⸻ Slide 15: Neutrophils • 50–70% of WBCs. • Nucleus 2–5 lobes. • First responders → attack bacteria. • Use phagocytosis + enzymes. • Die quickly → pus = dead neutrophils + bacteria. • Analogy: Neutrophils = foot soldiers. ⸻ Slide 16: Basophils • <1% WBCs. • Release histamine (dilates vessels, causes swelling/redness). • Release heparin (prevents clots). • Trigger inflammation → work with mast cells. • Analogy: Basophils = fire alarms. ⸻ Slide 17: Eosinophils • 2–4% WBCs. • Stain red-orange. • Bi-lobed nucleus. • Kill parasites, respond to allergies. • Release toxic chemicals (nitric oxide, enzymes). • Help control inflammation. • Analogy: Eosinophils = exterminators. ⸻ Slide 18: Monocytes • 2–8% WBCs. • Largest WBC, kidney-shaped nucleus. • Become macrophages in tissue. • Eat large pathogens, dead cells. • Call fibrocytes → scar tissue. • Analogy: Monocytes = garbage trucks. ⸻ Slide 19: Lymphocytes • 20–30% WBCs. • Big nucleus, little cytoplasm. • Most live in lymph tissue. • Types: • T cells: attack infected cells. • B cells: make antibodies. • NK cells: kill cancer/virus cells. • Analogy: Lymphocytes = special forces. ⸻ Slide 20: WBC Production • From hemocytoblasts. • Myeloid stem cells: all except lymphocytes. • Lymphoid stem cells: lymphocytes. • Colony-Stimulating Factors (CSFs): • M-CSF = monocytes. • G-CSF = granulocytes. • GM-CSF = granulocytes + monocytes. • Multi-CSF = RBCs + WBCs + platelets. • Analogy: CSFs = managers assigning jobs. ⸻ Slide 21: Platelets • Fragments of cells, no nucleus. • Lifespan = 9–12 days. • Removed by spleen. • 2/3 stored for emergencies. • Analogy: Platelets = emergency patch kits. ⸻ Slide 22: Platelet Functions 1. Release clotting chemicals. 2. Form platelet plug at damage site. 3. Contract (actin + myosin) → shrink clot, close wound. • Analogy: Platelets = patch team pulling duct tape tight. ⸻ Slide 23: Hemostasis • Definition: stopping bleeding. • 3 phases: vascular, platelet, coagulation. • Analogy: Like fixing a leaking pipe step by step. ⸻ Slide 24: Vascular Phase • Vessel wall contracts (vascular spasm). • Endothelial cells: • Expose basement membrane. • Release endothelins → stimulate contraction/healing. • Become sticky → platelets attach. • Analogy: Pinch a hose to slow the leak. ⸻ Slide 25: Platelet Phase • Platelets stick to exposed collagen. • Form platelet plug (15 sec after injury). • Release chemicals: ADP, thromboxane A₂, serotonin, Ca²⁺, PDGF. • Feedback prevents over-clotting. • Analogy: Like putting your hand over a hole until repair arrives. ⸻ Slide 26: Coagulation Phase • Chain reaction of clotting factors. • Fibrinogen → fibrin (forms net). • Common pathway: 1. Factor X → prothrombinase. 2. Prothrombin → thrombin. 3. Fibrinogen → fibrin. • Clot retraction pulls vessel edges together. • Analogy: Casting a fishing net over the leak. ⸻ Slide 27: Fibrinolysis & Clotting Needs • Fibrinolysis: clot dissolves after healing. • t-PA → activates plasminogen → plasmin → digests fibrin. • Requirements for clotting: • Calcium (Ca²⁺): needed in all clotting steps. • Vitamin K: liver makes clotting factors; comes from food + gut bacteria. • Deficiency = bleeding problems. • Analogy: Once pipe is repaired, cut away the net (clot)

Key Documents and Figures in Early American History and Government Save Flashcards Learn Test Blocks Blast Match House of Burgesses The legislature for the Jamestown colony established by the Virginia Company in 1619; it was the first legislative assembly in North America Track progress 1 / 48 Profile Picture Created by Audreybehm1 Created just now Terms in this set (48) Original House of Burgesses The legislature for the Jamestown colony established by the Virginia Company in 1619; it was the first legislative assembly in North America Mayflower Compact The governing document for Plymouth Colony that established forms of self-government for the colonists Magna Carta A document limiting the power of the king of England and guaranteeing certain rights to Englishmen English Bill of Rights A document signed in 1689 that guaranteed the rights of English citizens Enlightenment An eighteenth-century movement inspired by European philosophers who believed that society's problems could be solved by reason and science John Locke Was an English philosopher who wrote Two Treatises of Government. Great Awakening a religious movement in the English colonies during the 1730s and 1740s that was heavily inspired by evangelical preachers Thomas Jefferson Was an American farmer, landholder, author, architect, lawyer, and statesman. He joined the Virginia House of Burgesses in 1768 and began advocating for American independence in the 1770's. Jefferson represented Virginia in the Second Continental Congress, during which time he drafted and revised the Declaration of Independence. He went on to serve as a diplomat to France and as the nation's first secretary of state, second vice president, and third president. Jefferson also founded the University of Virginia. John Hancock Was a Massachusetts statesman who served as the president of the Second Continental Congress. George Washington Worked early on as a surveyor of the Virginia colony. Washington became interested in western expansion in the Ohio Country and invested in the Ohio Company. In 1752, he accepted an appointment to the military as an officer. Two years later, he led a company to drive out the French from Fort Duquesne. Later, he went on to serve as the commander-in-chief of the colonies' Continental Army and to become the first President of the United States. Republican Government a government in which officials are representatives elected by the people; also known as a representative democracy Bill of Rights the first ten amendments to the Constitution, protecting freedoms guaranteed to citizens by the government Articles of Confederation the original federal constitution drafted by the Continental Congress in 1777 Shays' Rebellion a farmers' rebellion, led by Daniel Shays, against higher taxes in Massachusetts Confederation an alliance or league of governments pledged to work together Northwest Territory a vast territory north of the Ohio River and west of Pennsylvania as far as the Mississippi River James Madison Was a Patriot who represented Virginia in the Continental Congress. In 1787, he participated in the Constitutional Convention and was a leading voice in replacing the Articles of Confederation with a new plan for government. For his part in winning passage of the 1787 Constitution, he became known as the Father of the Constitution. Madison went on to serve as Thomas Jefferson's secretary of state and then to become the fourth president of the United States. Checks and Balances a system in which each branch of the government has the power to monitor and limit the actions of the other two Federalism a political system in which power is shared between the national government and state governments The Federalist Papers a series of 85 essays, written by James Madison, Alexander Hamilton, and John Jay, that explained and defended the Constitution Separation of Powers a principle that divides power among the executive, legislative, and judicial branches of government Antifederalists one who opposed ratification of the Constitution Virginia Declaration of Rights a document listing the protected rights of Virginians, which was incorporated into the Virginia state constitution in 1776; it influenced a number of later documents, including the Declaration of Independence and the Bill of Rights Limited Government a principle stating that the government has only as much authority as the people give it and, therefore, its power is limited; government in which government actions are limited by law John Marshall was the fourth Chief Justice of the United States. After serving under George Washington in the Revolutionary War, including the winter at Valley Forge, Marshall held various law and political positions. As chief justice, Marshall participated in more than 1,000 decisions, writing more than 500 of them himself, often advancing and defending judicial power and the principles of American federalism. Judicial Review the power of the Supreme Court to decide whether acts of a president or laws passed by Congress are constitutional Louisiana Purchase the 1803 purchase from France by the United States of the territory between the Mississippi River and the Rocky Mountains Monroe Doctrine a foreign policy doctrine set forth by President Monroe in 1823 that discouraged European intervention in the Western Hemisphere Andrew Jackson was an American military officer before serving in the U.S. House of Representatives and Senate, and finally as the seventh U.S. President from 1829 to 1837. As a general in the U.S. Army during the War of 1812, Jackson successfully defended New Orleans. As President, he vetoed the renewal of the charter of the Bank of the United States, opposed the nullification issue in South Carolina, and initiated the spoils system. Nullification a theory that states could nullify, or void, any federal law they deemed unconstitutional Indian Removal Act an act passed by Congress in 1830 that allowed the federal government to negotiate land exchanges with the American Indians in the Southeast Trail of Tears an act passed by Congress in 1830 that allowed the federal government to negotiate land exchanges with the American Indians in the Southeast Panic of 1837 the start of a prolonged downturn in the American economy touched off by changes in government policy Alexis de Tocqueville was a French aristocrat whose travels in the United States in the 1830's resulted in the publication of Democracy in America, an influential analysis of American politics. Industrial Revolution a shift from manual labor to mechanized work that began in Great Britain during the 1700's and spread to the United States around 1800 Underground Railroad a system that existed before the Civil War in which African American and white abolitionists helped people trying to escape enslavement travel to safe areas in the North and in Canada Abolitionists reformers who advocated a complete end to slavery Frederick Douglass was born into slavery in Maryland and escaped to the North in 1838. In 1841, he spontaneously shared his experiences of enslavement at an antislavery convention, and he soon became a speaker for the abolitionist cause. His autobiography, Narrative of the Life of Frederick Douglass, first published in 1845, reached still more people. During the Civil War, Douglass worked as an adviser to President Lincoln. Douglass also lent strong support to the women's movement. Second Great Awakening a religious revival movement in the first half of the 1800s Lucretia Mott was deeply committed to the ideal of reform. Known for her effective public speaking, she traveled the country promoting abolition. Frustrated by attempts to limit women's involvement in reform, Mott turned her attention to women's rights in the 1840's. She worked with Elizabeth Cady Stanton to organize the Seneca Falls Convention. Elizabeth Cady Stanton was a lively and often fiery crusader for women's rights. While raising a growing family, she worked with Lucretia Mott and others to organize the Seneca Falls Convention. From the beginning, she pushed for women to fight for the right to vote, helping shape the direction of the movement for years to come. Declaration of Sentiments a document created at the Seneca Fall Convention in 1848 that demanded equal rights for women Susan B. Anthony was a campaigner for reforms and civil rights throughout her life. At different times she took up the cause of abolition, temperance, and working women's rights. But it is for the cause of woman suffrage that Anthony is best known. In 1869, she and her friend, Elizabeth Cady Stanton, formed the National Woman Suffrage Association (NWSA), which led to over 30 years of relentless lecture tours, lobbying, and civil disobedience geared toward gaining the vote for women. Suffrage the right to vote Manifest Destiny the 19th century doctrine that westward expansion of the United States was not only inevitable but a God-given right Sam Houston was the only American to serve as governor of two different states—first Tennessee, then Texas. In between, he was commander of the Texan army, president of the Republic of Texas, and U.S. senator from Texas. Although an enslaver, Houston opposed the spread of slavery into the West. He was removed from the governorship of Texas after speaking out against Texas seceding from the Union. James K. Polk was a lawyer and politician who served as the 11th president of the United States from 1845 to 1849. Before being elected President, Polk served in the Tennessee legislature and as Speaker of the U.S. House of Representatives. As President, Polk led the United States through the Mexican-American War, resulting in the United States gaining large territories along the Pacific coast and in the Southwest. Treaty of Guadalupe Hidalgo the 1848 treaty ending the Mexican-American War Add or remove terms Learn More You can also click the terms or definitions to blur or reveal them Review with an activity About us About Quizlet How Quizlet works Careers Advertise with us Get the app For students Flashcards Test Learn Solutions Modern Learning Lab Quizlet Plus Study Guides Pomodoro timer For teachers Live Blog Be the Change Quizlet Plus for teachers Resources Help center Honor code Community guidelines Terms Privacy California Privacy Your Privacy/Cookie Choices Ads and Cookie Settings Interest-Based Advertising Quizlet for Schools Parents Language English (USA) © 2025 Quizlet, Inc. COPPA Safe Harbor Certification seal Home Your library Notifications 5 Your courses AP Psychology Advanced Chemist... Honors Algebra 2 New folder Start here Flashcards Study Guides Practice Tests Expert Solutions Home Your library Notifications 5 AP Psychology Advanced Chemist... 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ASSESSMENT OF THE LIVER Anatomic and Physiologic Overview The liver, the largest gland of the body and a major organ, can be considered a chemical factory that manufactures, stores, alters, and excretes a large number of substances involved in metabolism (Hammer & McPhee, 2019; Sanyal, Boyer, Terrault, et al., 2018). The location of the liver is essential because it receives nutrient-rich blood directly from the gastrointestinal (GI) tract and then either stores or transforms these nutrients into chemicals that are used elsewhere in the body for metabolic needs. The liver is especially important in the regulation of glucose and protein metabolism. The liver manufactures and secretes bile, which has a major role in the digestion and absorption of fats in the GI tract. The liver removes waste products from the bloodstream and secretes them into the bile. The bile produced by the liver is stored temporarily in the gallbladder until it is needed for digestion, at which time the gallbladder empties and bile enters the intestine (see Fig. 43-1). Anatomy of the Liver The liver is a large, highly vascular organ located behind the ribs in the upper right portion of the abdominal cavity. It weighs between 1200 and 1500 g in the average adult and is divided into four lobes. A thin layer of connective tissue surrounds each lobe, extending into the lobe itself and dividing the liver mass into small, functional units called lobules (Barrett, Barman, Brooks, et al., 2019; Hammer & McPhee, 2019). The circulation of the blood into and out of the liver is of major importance to liver function. The blood that perfuses the liver comes from two sources. Approximately 80% of the blood supply comes from the portal vein, which drains the GI tract and is rich in nutrients but lacks oxygen. The remainder of the blood supply enters by way of the hepatic artery and is rich in oxygen. Terminal branches of these two blood vessels join to form common capillary beds, which constitute the sinusoids of the liver (see Fig. 43-2). Thus, a mixture of venous and arterial blood bathes the hepatocytes (liver cells). The sinusoids empty into venules that occupy the center of each liver lobule and are called the central veins. The central veins join to form the hepatic vein, which constitutes the venous drainage from the liver and empties into the inferior vena cava, close to the diaphragm (Barrett et al., 2019; Hammer & McPhee, 2019; Sanyal et al., 2018). In addition to hepatocytes, phagocytic cells belonging to the reticuloendothelial system are present in the liver. Other organs that contain reticuloendothelial cells are the spleen, bone marrow, lymph nodes, and lungs. In the liver, these cells are called Kupffer cells (Barrett et al., 2019; Hammer & McPhee, 2019). As the most common phagocyte in the human body, their main function is to engulf particulate matter (e.g., bacteria) that enters the liver through the portal blood. The smallest bile ducts, called canaliculi, are located between the lobules of the liver. The canaliculi receive secretions from the hepatocytes and carry them to larger bile ducts, which eventually form the hepatic duct. The hepatic duct from the liver and the cystic duct from the gallbladder join to form the common bile duct, which empties into the small intestine. The sphincter of Oddi, located at the junction where the common bile duct enters the duodenum, controls the flow of bile into the intestine. Figure 43-1 • The liver and biliary system, including the gallbladder and bile ducts. Reprinted with permission from Norris, T. L. (2019). Porth’s pathophysiology: Concepts of altered health states (10th ed., Fig. 38.1). Philadelphia, PA: Wolters Kluwer. Figure 43-2 • A section of liver lobule showing the location of hepatic veins, hepatic cells, liver sinusoids, and branches of the portal vein and hepatic artery. Functions of the Liver Glucose Metabolism The liver plays a major role in the metabolism of glucose and the regulation of blood glucose concentration. After a meal, glucose is taken up from the portal venous blood by the liver and converted into glycogen, which is stored in the hepatocytes. Subsequently, the glycogen is converted back to glucose through a process called glycogenolysis and is released as needed into the bloodstream to maintain normal levels of blood glucose. However, this process provides a limited amount of glucose. Additional glucose can be synthesized by the liver through a process called gluconeogenesis. For this process, the liver uses amino acids from protein breakdown or lactate produced by exercising muscles. This process occurs in response to hypoglycemia (Barrett et al., 2019; Hammer & McPhee, 2019). Ammonia Conversion The use of amino acids from protein for gluconeogenesis results in the formation of ammonia as a by-product. The liver converts this metabolically generated ammonia into urea. Ammonia produced by bacteria in the intestines is also removed from portal blood for urea synthesis. In this way, the liver converts ammonia, a potential toxin, into urea, a compound that is excreted in the urine (Barrett et al., 2019; Hammer & McPhee, 2019). Protein Metabolism The liver also plays an important role in protein metabolism. It synthesizes almost all of the plasma proteins (except gamma-globulin), including albumin, alpha-globulins and beta-globulins, blood clotting factors, specific transport proteins, and most of the plasma lipoproteins. Vitamin K is required by the liver for synthesis of prothrombin and some of the other clotting factors. Amino acids are used by the liver for protein synthesis (Barrett et al., 2019; Hammer & McPhee, 2019). Fat Metabolism The liver is also active in fat metabolism. Fatty acids can be broken down for the production of energy and ketone bodies (acetoacetic acid, beta-hydroxybutyric acid, and acetone). Ketone bodies are small compounds that can enter the bloodstream and provide a source of energy for muscles and other tissues. Breakdown of fatty acids into ketone bodies occurs primarily when the availability of glucose for metabolism is limited, as in starvation or in uncontrolled diabetes. Fatty acids and their metabolic products are also used for the synthesis of cholesterol, lecithin, lipoproteins, and other complex lipids (Hammer & McPhee, 2019; Sanyal et al., 2018). Vitamin and Iron Storage Vitamins A, B, and D and several of the B-complex vitamins are stored in large amounts in the liver. Certain substances, such as iron and copper, are also stored in the liver. Bile Formation Bile is continuously formed by the hepatocytes and collected in the canaliculi and bile ducts. It is composed mainly of water and electrolytes such as sodium, potassium, calcium, chloride, and bicarbonate, and it also contains significant amounts of lecithin, fatty acids, cholesterol, bilirubin, and bile salts. Bile is collected and stored in the gallbladder and is emptied into the intestine as needed for digestion. The functions of bile are excretory, as in the excretion of bilirubin; bile also serves as an aid to digestion through the emulsification of fats by bile salts. Bile salts are synthesized by the hepatocytes from cholesterol. After conjugation or binding with amino acids (taurine and glycine), bile salts are excreted into the bile. The bile salts, together with cholesterol and lecithin, are required for emulsification of fats in the intestine, which is necessary for efficient digestion and absorption. Bile salts are then reabsorbed, primarily in the distal ileum, into portal blood for return to the liver and are again excreted into the bile. This pathway from hepatocytes to bile to intestine and back to the hepatocytes is called the enterohepatic circulation. Because of the enterohepatic circulation, only a small fraction of the bile salts that enter the intestine are excreted in the feces. This decreases the need for active synthesis of bile salts by the liver cells (Hammer & McPhee, 2019). Bilirubin Excretion Bilirubin is a pigment derived from the breakdown of hemoglobin by cells of the reticuloendothelial system, including the Kupffer cells of the liver. Hepatocytes remove bilirubin from the blood and chemically modify it through conjugation to glucuronic acid, which makes the bilirubin more soluble in aqueous solutions. The conjugated bilirubin is secreted by the hepatocytes into the adjacent bile canaliculi and is eventually carried in the bile into the duodenum. p. 1366 p. 1367 In the small intestine, bilirubin is converted into urobilinogen, which is partially excreted in the feces and partially absorbed through the intestinal mucosa into the portal blood. Much of this reabsorbed urobilinogen is removed by the hepatocytes and secreted into the bile once again (enterohepatic circulation). Some of the urobilinogen enters the systemic circulation and is excreted by the kidneys in the urine. Elimination of bilirubin in the bile represents the major route of its excretion. Drug Metabolism The liver metabolizes many medications, such as barbiturates, opioids, sedatives, anesthetics, and amphetamines (Goldman & Schafer, 2019; Hammer & McPhee, 2019; Sanyal et al., 2018). Metabolism generally results in drug inactivation, although activation may also occur. One of the important pathways for medication metabolism involves conjugation (binding) of the medication with a variety of compounds, such as glucuronic acid or acetic acid, to form more soluble substances. These substances may be excreted in the feces or urine, similar to bilirubin excretion. Bioavailability is the fraction of the given medication that actually reaches the systemic circulation. The bioavailability of an oral medication (absorbed from the GI tract) can be decreased if the medication is metabolized to a great extent by the liver before it reaches the systemic circulation; this is known as first-pass effect. Some medications have such a large first-pass effect that their use is essentially limited to the parenteral route, or oral doses must be substantially larger than parenteral doses to achieve the same effect. Gerontologic Considerations Chart 43-1 summarizes age-related changes in the liver. In the older adult, the most common change in the liver is a decrease in size and weight, accompanied by a decrease in total hepatic blood flow. However, in general, these decreases are proportional to the decreases in body size and weight seen in normal aging. Results of liver function tests do not normally change with age; abnormal results in older patients indicate abnormal liver function and are not a result of the aging process itself. Chart 43-1 Age-Related Changes of the Hepatobiliary System •Atypical clinical presentation of biliary disease •Decreases in the following: •Clearance of hepatitis B surface antigen •Drug metabolism and clearance capabilities •Intestinal and portal vein blood flow •Gallbladder contraction after a meal •Rate of replacement and or repair of liver cells after injury •Size and weight of the liver, particularly in women •Increased prevalence of gallstones due to the increase in cholesterol secretion in bile •More rapid progression of hepatitis C infection and lower response rate to therapy •More severe complications of biliary tract disease Adapted from Townsend, C. M., Beauchamp, R. D., Evers, B. M., et al. (2016). Sabiston’s textbook of surgery: The biological basis of modern surgical practice. Philadelphia, PA: Elsevier. Metabolism of medications by the liver decreases in the older adult, but such changes are usually accompanied by changes in intestinal absorption, renal excretion, and altered body distribution of some medications secondary to changes in fat deposition. These alterations necessitate careful medication administration and monitoring; if appropriate, reduced dosages may be needed to prevent medication toxicity

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