Water-Soluble vs. Lipid Soluble Hormones

Whether a hormone is water-soluble or lipid-soluble determines how they produce their _____________.

responses

Where are the receptors of water-soluble hormones?

plasma membrane

Where are the receptors of lipid-soluble hormones?

cytosol or nucleus

Where are the target molecules located for water-soluble hormones?

cytosol

Where are the target molecules located for lipid-soluble hormones?

nucleus

Do water-soluble hormones have second messengers?

yes

Do lipid-soluble hormones have second messengers?

no

What is the net result of water-soluble hormones?

phosphorylation proteins and modulated metabolic pathways

What is the net result of lipid-soluble hormones?

new proteins and changes in synthesis of proteins

Water-soluble hormones are generally ______ - acting and effects are _________ lived.

fast, short

Lipid-soluble hormones have ________ onset and ___________ duration.

slow, longer

Where is water-soluble hormone's first messenger located?

outside the cell

Where is water-soluble hormone's second messenger located?

inside the cell

What is the first messenger of water-soluble hormones?

the hormone itself

What is the primary second messenger for water-soluble hormones?

cAMP

What does the second messenger of water-soluble hormones initiate?

biochemical cascade

In addition to cAMP what are the other secondary messengers of water-soluble hormones?

1) IP3

2) DAG

3) Calcium

In water-soluble hormones the hormone does NOT enter the cell without the help of a ____________ in the plasma membrane

receptor

Steroid hormones ___________ across the plasma membrane.

diffuse