Inflammation/Lymphatics

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module 2

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260 Terms

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What is an allergy?
Over-reaction of the immune system to a harmless antigen (allergens)
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How are hypersensitivity reactions grouped?
Grouped into four types according to the effector mechanism responsible for producing the reaction
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Type I
Binding of antigen to surface IgE, primarily on mast cells. Degranulation causes the release of inflammatory mediators
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Type II
Small molecules binding to cell surface components modify the antigenicity of the molecule rendering them immunogenic. B cell response to the antigen destroys the cell
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Type III
Soluble protein antigens bind to immunoglobulin forming immune complexes. These complexes deposit on small blood vessels triggering complement cascade and inflammation
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Type IV
Antigen-specific effector T cell
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Type 1 hypersensitivity - what is the antigen, what is the effector mechanism and reaction
Antigen = soluble antigen
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Effector mechanism = mast cell degranulation
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Reaction = Allergic rhinitis, asthma, systemic anaphylaxis
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FceRI
Expressed constitutively on mast cells/basophils induced on activated eosinophils binds IgE in the absence of antigen
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What are allergic reactions mediated by
H1 receptors on smooth muscle and endothelial cell
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What are histamines derived from
histidines
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What receptors do histamines bind to
H1, H2 and H3
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What is the purpose of a histamine?
Increase permeability/edema, smooth muscle contraction
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How is an invading parasite attacked and expelled from the host?
By breaking down the ECM proteins allowing invasion by leukocytes - enables the leukocytes to attack the parasite
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What type of hypersensitivity is Asthma/allergic Rhinitis
Type I
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What is Asthma/allergic rhinitis
Reaction to an inhaled allergen such as pollen, house dust mite, dander
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What are 20% of the allergies in North America against?
Cysteine protease of D. pteronissimus
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Wheal and flare
(a reaction) rash or hives (irregular, blanch raised areas with redness)
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-Local urticarial reaction (hives!)
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How does anaphylaxis present in felines?
Coughing, dyspnea (respiratory), vomiting and diarrhea (GI)
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-Common sources of allergens = house dust mites, fleas
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-Presentation = atopic dermatitis
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Common allergies in equine
Sweet itch = allergy to culicoides (midge bite)
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Heaves = respiratory manifestation of allergy to mold ex: aspergillum fumigates, alternaria tenuis
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Sweet Itch
Equine
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-Summer seasonal recurrent dermatitis - allergy to the saliva of biting insects such as culicoides (midge), sand flies and black flies
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How does sweet itch manifest
Intense itching (pruitis) local hair loss (alopecia) and a thickening and ridging of the skin in the affected area
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Heaves
Chronic obstructive pulmonary disease
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-Respiratory manifestation of allergy to mold ex: aspergillum fumigates, alternaria tenuis
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Type II hyper sensitivity antigen
Altered cell surface component
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Type II hypersensitivity effector mechanisms
IgG binds to novel antigen which triggers the complement cascade
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-FcR targets leukocytes
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-IgG binds to cell surface receptor (autoimmunity)
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Type II hypersensitivity reaction
Hemolytic anemia, autoimmunity
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Haptenisation
The reaction of an antigenic compound (a hapten) with a carrier protein in order to stimulate an immune response.
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-Drug modification of a protein antigen
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-Penicillin derivatives - anemia
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Neonatal isoerythrolysis
Ex: Foal's red blood cells are destroyed by antibodies in the mare's colostrum
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Ex: Cats - kitten with blood group A or AB is born to a B mother
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-All type B cats have high titer anti -A IgM
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-Is rare in canines, spontaneously arising alloantibodies are infrequent
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Clinical signs of neonatal isoerythrolysis in cats
Hemolytic anemia, jaundice, hemoglobinuria, weakness, lethargy
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Hyperacute graft rejection
Immediate and rare
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Preexisting antibody to the antigens of the graft
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-Rhesus D reaction
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What do A erythrocytes express on gangliosides
N-Glycolyl neuraminic acid
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What do B erythrocytes express
N-acetyl neuraminic acid
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AB erythrocytes express both ______ and _______
N-glycolyl neuraminic acid and N-acetyl neuraminic acid
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Cats with B blood group lack the _____ enzyme that converts _____ to _______
Hydroxylase, acetyl to glycolyl
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How to treat neonatal isoerythrolysis in cats
Blood type and prevent exposure to colostrum - Type A foster queen or milk replacement
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Type III hypersensitivity antigen
Soluble antigen
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Type III Hypersensitivity effector mechanisms
Immune complexes, complement, phagocytes
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Type III hypersensitivity reaction
Arthus reaction (ex: to a tetanus vaccine), serum sickness (to drugs or antitoxins), Farmer's lung (hypersensitivity pneumonitis)
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Type III hypersensitivity high dose antigen
vasculitis, nephritis, arthritis
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Type III hypersensitivity Subcutaneous antigen
Arthus reaction
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Type III hypersensitivity inhaled antigen
Famer's lung
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What is an example of an infectious disease with an immune complex component and an example of one with autoimmune conditions?
Immune complex component = feline infectious peritonitis (FIP)
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Autoimmune = Systemic lupus erythematosus (SLE)
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Type IV hypersensitivity antigen
Cell associated antigen
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Type IV hypersensitivity effector mechanism
macrophages, eosinophils, CTLs
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Type IV hypersensitivity reaction
chronic asthma, allergic rhinitis, contact dermatitis, tuberculin reaction
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Type IV hypersensitivity is synonymous with what kind of reaction? What does it consist of? Example?
Delayed-type hypersensitivity (DTH), occurs 1-3 days after antigen exposure
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ex: tuberculin reaction = small amount of protein extract from m.tuberculuosis is infected subcutaneously - if immune M. tuberculosis proteins are processed, used to stimulate Th cells with then promote a local inflammatory response recruiting leukocytes at the site of injection
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(other examples : nickel allergy, poison ivy)
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Atopic dermatitis in canines and felines
Type I hypersensitivity reaction to allergens: dust mite (dermatophagoides pteronyssinus) , flour mite (dermatophagoides farinae) or saliva of flea (ctenocephalides felis)
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Treatment for atopic dermatitis
Identify allergen, prevent further exposure to allergen
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-Hyposensitization may be a good treatment for house dust mites
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Immunodeficiency results from
A defect at any stage of the immune response
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Are congenital immunodeficiencies rare?
Yes, many are X-linked and more common in males
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Complement deficiency - C3 example
Autosomal recessive - single base pair deletion in the C3 gene
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-Brittany spaniels had increased susceptibility to bacterial infection
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Inherited IgA deficiency
secreted immunoglobulin resistant to proteolytic degradation
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secretory component mediates transport across epithelial surfaces
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high affinity receptor on monocytes and neutrophils
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What condition in Irish setters is a deficiency of b-chain LFA-1 and what does it cause?
LAD (Leukocyte adhesion deficiency)
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-There is an absence of a functional LFA molecule - prevents adhesion of granulocytes to the endothelium - no migration!
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Secondary immunodeficiency following drug treatment
Corticosteriods - anti-inflammatory agent
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Increased production of IkBa - binds transcription factor NFkB preventing it from entering the nucleus and enhancing cytokine gene expression
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Cyclosporin A (secondary immunodeficiency following drug treatment)
Inhibits T cell activation by disrupting the transduction of signals from the T cell receptor
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Cancer (secondary immunodeficiency following drug treatment)
Affects rapidly dividing cells in the gut and bone marrow - causes immunosuppression
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-WBC count should be monitored
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immunodeficiency in response to viral infection - Lentiviruses (FIV, HIV,)
T helper cell depletion
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immunodeficiency in response to viral infection - FeLV
Thymic atrophy
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immunodeficiency in response to viral infection - distemper, parvo
Transient lymphocytolysis
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immunodeficiency in response to viral infection- parasite infection
Generalized immunosuppression
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Neonatal isoerythrolysis - foals
Foal's red blood cells are destroyed by antibodies in the mare's colostrum
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Inflammation
A complex, regulated yet non-specific response to physical/chemical injury or biological agent
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tumor, rubor, calor, dolor, functio laesa
The signs of inflammation in spanish; swelling, redness, heat, pain, loss of function
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What are some of the benefits of inflammation?
-Dilution/inactivation of pathogens and toxins
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-Killing pathogens/foreign materials/Necrotic tissue/neoplastic cells
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-Wound healing factors
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-Restrict movement for healing
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-Increase temp to induce vasodilation and inhibit replication of pathogens
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What are some of the disadvantages of inflammation
-Collateral damage
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-Excessive and/or prolonged inflammatory response can cause problems (IBD, Johne's disease, pemphigus, lupus, anaphylaxis, glomerulonephritis)
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-Anti inflammatory meds
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What suffix means inflammation?
-itis
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Inflammation of the skin
Dermatitis
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Inflammation of the kidney
Nephritis