W10 GBS, CMT, poliomyelitis

guillaine barre syndrome

(auto-immune) demyelination disease of PNS that affects the myelin sheath

landry’s paralysis

other name for GBS

stocking glove pattern

usual pattern of manifestation for GBS

post-infection

GBS s/sx:

___

idiopathic

self-limiting

ascending

demyelinating

idiopathic

GBS s/sx:

post-infection

___

self-limiting

ascending

demyelinating

self-limiting

GBS s/sx:

post-infection

idiopathic

___

ascending

demyelinating

ascending

GBS s/sx:

post-infection

idiopathic

self-limiting

___

demyelinating

demyelinating

GBS s/sx:

post-infection

idiopathic

self-limiting

ascending

___

campylobacter jejuni

most common microorganism agent in precedent infection in GBS

IgG

what Ig is the most common and is affected in GBS?

IgA

what Ig is seen in the mucuous membrane?

IgM

what Ig is used in response to new bacteria?

IgE

what Ig is seen in allergies?

ascending

hallmark of GBS:

___

bilateral

symmetrical

paralysis

bilateral

hallmark of GBS:

ascending

___

symmetrical

paralysis

symmetrical

hallmark of GBS:

ascending

bilateral

___

paralysis

paralysis

hallmark of GBS:

ascending

bilateral

symmetrical

___

3-18

estimated time for full recovery of GBS pts is ___mos

male

GBS poor prognosticating factors:

____

advanced age

diarrhea

cytomegalovirus

axonal forms

advanced age

GBS poor prognosticating factors:

male

___

diarrhea

cytomegalovirus

axonal forms

diarrhea

GBS poor prognosticating factors:

male

advanced age

___

cytomegalovirus

axonal forms

cytomegalovirus

GBS poor prognosticating factors:

male

advanced age

diarrhea

___

axonal forms

axonal forms

GBS poor prognosticating factors:

male

advanced age

diarrhea

cytomegalovirus

___

facial diaparesis

CN7 problem manifestation in GBS

acute inflammatory deyelinating polyneuropathy

most common variant of GBS

decreased

in AIDP, NCV findings are ___

CN 7, 9, 10, 11

CN affected in AIDP

europe, south africa

places where AIDP is more common

paresthesia

most common sx in AIDP

aching

what type of pain is manifested in AIDP?

onufruwicz nucleus

a small group of neurons located at ventral horns of sacral spinal cord that controls bowel and bladder function

acute motor axonal neuropathy

subtype of GBS that is more common in children and young adults

wallerian degeneration

AMAN has ___ but unaffected myelin sheath

acute motor sensory axonal neuropathy

subtype of GBS that is more common in elderly

normal

in axonal GBS, NCV findings are ___

opthlamoplegia, ataxia, areflexia

triad of miller fisher syndrome

opthalmoplegia

___ is paralysis or difficulty in controlling the eyeball

extra ocular

what mm group is weakened in opthalmoplegia?

ptosis

CN3 affectation for levator palpebrae may result in ___

miller fisher syndrome

regional variant of GBS that account for 5% of all cases

acute pandysautonomia

autonomic failure; most fatal in GBS; prone to infections

respiratory decompensation

most common cause of death in GBS pts

phrenic

respiratory decompensation is due to the affectation of the ___ nn

AIDP

what variant of GBS has these clinical features: paresthesia, symmetrical weakness of all limbs, hypo/areflexia, mild sensory sx, aching pain

axonal

what variant of GBS has these clinical features: symmetrical weakness, (N) or inc reflexes, variable sensory sx, respiratory involvement

axonal

AMAN and AMSAN are ____ type of demyelination

demyelinating

AIDP is ___ type of demyelination

axonal and demyelinating

MFS is ____ type of demyelination

camoylobacter jejuni, cytomegalovirus, epstein-barr virus

3 most common agents of infections in GBS

swine (influenza) flu

what vaccination was it discovered that may cause GBS?

idiopathic

the cause of GBS is ___

molecular mimicry

term that describes the pathophysiology of GBS

myelin sheath

structure that is primarily affected in GBS

inflammation

secondary axonal degeneration is most likely due to ___

increased CSF protein level

finding in lumbar puncture/lumbar tap that may indicated GBS

brighton criteria

name of decriptive criteria used in diagnosing GBS

85

since GBS is self-limit, it is expected to have approximately ___% of pts to have full recovery

plasmapheresis

medical procedure for removal, return or exhange of blood

IgG

what immunoglobulin is used in IVIg treatment in GBS?

3 months

treatment for GBS should be checked for ___ before continuining or switching to a new treatment

difficulty swallowing

bulbar affectation in GBS may cause pt to have ___

CN3

CN involvement for opthalmoplegia and ptsosis

CN 3, 4, 6

CN involvement that are spared in AIDP but affected in MFS

CN3

longest CN intracranially is ___

CN10

longest CN extracranially is ___

charcot marie tooth disease

most common hereditary peripheral sensory motor neuropathy

17

CMTD has affectation of the chromosome ___

sensory loss, motor loss, areflexia

CMTD triad

inverted champgane bottle, strok leg deformity

seen in CMTD pts in postural ax of the LE d/t mm atrophy

longitudinal

the ___ arch is affected in pes cavus in CMTD

CMTD1

type of CMTD that is hypertrophic and affects the myelin sheath

first

in CMTD1, sx manifest during ___ decade of life

onion bulb formation

sx term seen in the myelin sheaths in CMTD1 as a result of repeated cycles of demyelination and remyelination

CMDT2

type of CMTD that is axonal and has wallerian degeneration

second

in CMTD2, sx manifest during ___ decade of life

CMTD3

type of CMTD that is a hypertrophic neuropathy, is seen in infants and is the severe form of CMTD

dejerine-sottas

other name for CMTD3

refsum’s disease

other name for CMTD4

CMTD4

type of CMTD that has overaccumulation of phytanic acid in the schwann cells

phytanic acid

in CMTD4, there is oveaccumulation of the ___ in the schwann cells

CN 1, 8

CN affectation in CMTD4

CMTD5

type of CMTD that is associated with spinocerebellar degeneration, which leads to ataxia

CMTD6

type of CMTD that is associated with optic neuritis

CMTD7

type of CMTD that is associated with retinitis pigmentosa and there is a chance of blindness

CMTD 1, 2

which CMTD type/s is/are autosomal dominant?

CMTD4

which CMTD type/s is/are autosomal recessive?

CMTD3

which CMTD type/s is/are both autosomal dominant and autosomal recessive?

decreased, normal

in CMTD1, NCV is ___ whereas in CMTD2 it is ___

heine-medin disease

other name for poliomyelitis

picornavirus

most common viral agent that causes polio is ___

fecal/oral

picornavirus may be spread via ___ route

brunhilde

type of poliomyelitis that is most paralytogenic

lansing

type of poliomyelitis that is most frequent

leon

type of poliomyelitis that is most fatal

salk

polio vaccine that is administered intramuscularlly

sabin

polio vaccine that is administered orally

2

the acute stage for poliomyelitis lasts for ___ years

asymptomatic polio

minor type of poliomyelitis that does not usually present with s/sx and is associated with viremia

abortive polio

minor type of poliomyelitis that is influenza-like

non-paralytic polio

major type of poliomyelitis that has meningitis and lhermitte sign