exam 1 - immune cells

list the major immune cell types in order from most to least abundant

neutrophils, lymphocytes, monocytes, eosinophils, basophils

blood percentage value of neutrophils

54-62%

blood percentage value of lymphocytes

25-33%

blood percentage value of monocytes

2-10%

blood percentage value of eosinophils

1-6%

blood percentage of basophils

<1%

lifetime of neutrophils

hours-days

in spleen and other tissue

lifetime of lymphocytes

weeks-years

lifetime of monocytes

hours-days

lifetime of eosinophils

8-12 days

circulating for 4-5 days

lifetime of basophils

hours-days

list the 4 types of lymphocytes

B cells

cytotoxic T (CD8) cells

helper T (CD4) cells

natural killer (NK) cells

what do B cells do

initiate antibody mediated immune response by binding specific antigens to the plasma membrane receptors

present antigen to CD4

what is the active form of a B cell

plasma cells

what do plasma cells do

secrete antibodies

what does CD8 do

bind to antigens on plasma membrane of target or virally infected cell and kill it

linked to autoimmune diseases

what does CD4 do

secrete cytokines to activate B cells, CD8, NK, macrophages

doesn’t actually bind to anything

what do NK cells do

bind directly and nonspecifically to virus infected and cancer cells and kill them

function as killer cells in antibody-dependent cellular cytotoxicity (ADCC)