Clotting Factors and proteins

1 fibrinogen

Clot formation

2 prothrombin

activation of I,V,VII,VIII, XI, XIII, protein C, platelets

3 TF

Co factor of VIIa

4 Calcium

Facilitates coagulation factor binding to phospholipids

5 Proacclerin, labile factor

Co-factor of X-prothrombinase complex

7 Stable factor, proconvertin

Activates factors 9, 10

8 Antihaemophilic factor A

Co-factor of 9-tenase complex

9 Antihaemophilic factor B or Christmas factor

Activates 10, Forms tenase complex with factor 8

10 Stuart-Prower factor

Prothrombinase complex with factor 5, Activates factor 2

11 Plasma thromboplastin antecedent

Activates factor 9

12 Hageman factor

Activates factor 11, 7, and prekalikrein

13 Fibrin-stabilising Factor

Crosslinks fibrin

factor 12, prekallikrein, factor 11

surface bound zymogens

factor 7, 9, 10, 2, protein c

vitamin k-dependent zymogens

high molecular weight kininogen, factor 8, factor 5, fibrinogen, protein s

cofactors/substrates