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What are carbohydrates?
Energy-yielding macronutrients made of carbon, hydrogen, and oxygen that serve as the primary energy source for the brain
What are the three main types of carbohydrates?
Monosaccharides, disaccharides, and polysaccharides
What are the most common monosaccharides?
Glucose, fructose, and galactose
What is the structure of a disaccharide?
Two monosaccharides joined by a glycosidic bond
What monosaccharides make up sucrose?
Glucose and fructose
What monosaccharides make up lactose?
Glucose and galactose
What monosaccharides make up maltose?
Glucose and glucose
What are oligosaccharides?
Carbohydrates composed of 3-10 monosaccharides that are often fermented in the colon
What are polysaccharides?
Long chains of monosaccharides such as starch, glycogen, and fiber
What is starch?
The storage form of carbohydrate in plants composed of amylose and amylopectin
What is glycogen?
The storage form of carbohydrate in animals stored in the liver and muscles
What is dietary fiber?
Indigestible carbohydrates found in plant foods
Where does carbohydrate digestion begin?
In the mouth
What enzyme begins carbohydrate digestion?
Salivary amylase
Why does carbohydrate digestion stop in the stomach?
The acidic environment inactivates amylase
Where does most carbohydrate digestion occur?
In the small intestine
What enzyme continues starch digestion in the small intestine?
Pancreatic amylase
What enzymes complete carbohydrate digestion at the brush border?
Maltase, lactase, sucrase, and isomaltase
How are glucose and galactose absorbed?
By active transport via SGLT1
How is fructose absorbed?
By facilitated diffusion via GLUT5
What transporter moves monosaccharides into the bloodstream?
GLUT2
What is euglycemia?
The maintenance of normal blood glucose levels
What is the normal fasting blood glucose range?
70-110 mg/100 mL
What hormone lowers blood glucose levels?
Insulin
What hormone raises blood glucose levels?
Glucagon
What hormone increases glucose availability during stress?
Epinephrine
What hormone promotes gluconeogenesis during fasting and stress?
Cortisol
What is glycolysis?
The breakdown of glucose into pyruvate to produce ATP
What is glycogenesis?
The conversion of glucose to glycogen for storage
What is glycogenolysis?
The breakdown of glycogen to release glucose
What is gluconeogenesis?
The formation of glucose from non-carbohydrate sources
What is the pentose phosphate pathway?
A pathway that produces NADPH and ribose-5-phosphate
What is the glycemic index (GI)?
A measure of how quickly a food raises blood glucose
What is glycemic load (GL)?
A measure that accounts for both carbohydrate quality and quantity
What are benefits of a low-GI diet?
Lower cholesterol, reduced risk of type 2 diabetes, improved blood glucose control
What is high-fructose corn syrup (HFCS)?
A liquid sweetener derived from corn used widely in processed foods
What is the composition of HFCS?
Approximately 55% fructose and 42% glucose
How does HFCS compare to sucrose?
They are nearly identical in composition and metabolism
What causes lactose intolerance?
A deficiency of the enzyme lactase
What is cow's milk allergy?
An immune reaction to milk proteins
What is soluble fiber?
Fiber that dissolves in water and slows digestion
What is insoluble fiber?
Fiber that increases stool bulk and promotes bowel regularity
What are examples of soluble fiber?
Pectins, gums, and mucilages
What are examples of insoluble fiber?
Cellulose, hemicellulose, and lignin
What are health benefits of dietary fiber?
Improved satiety, lower cholesterol, better glycemic control
What are health risks of low fiber intake?
Constipation, diverticulosis, and poor blood glucose control
What are lipids?
Energy-yielding macronutrients that provide 9 kcal per gram
What are the four main types of lipids?
Fatty acids, triglycerides, phospholipids, and sterols
What are the main functions of lipids?
Energy storage, insulation, cell membrane structure, and hormone production
What is a saturated fatty acid?
A fatty acid with no double bonds
What is a monounsaturated fatty acid?
A fatty acid with one double bond
What is a polyunsaturated fatty acid?
A fatty acid with two or more double bonds
What are essential fatty acids?
Fatty acids the body cannot synthesize and must obtain from the diet
What are the two essential fatty acids?
Linoleic acid (omega-6) and linolenic acid (omega-3)
What are the health roles of essential fatty acids?
Growth, inflammation regulation, and cardiovascular health
What is a triglyceride?
A lipid composed of a glycerol backbone and three fatty acids
What is the primary function of triglycerides?
Energy storage
What is a phospholipid?
A lipid with a glycerol backbone, two fatty acids, and a phosphate group
Why are phospholipids important?
They form cell membranes and act as emulsifiers
What is a sterol?
A lipid with a ring structure such as cholesterol
What is cholesterol used for in the body?
Hormone synthesis, bile acids, and vitamin D production
Where does lipid digestion mainly occur?
In the small intestine
What hormone stimulates bile release during fat digestion?
Cholecystokinin (CCK)
What is the function of bile?
Emulsifies fats to aid digestion
What are micelles?
Structures that transport lipid digestion products to intestinal cells
What are chylomicrons?
Lipoproteins that transport dietary fat through the lymph and blood
What is the building block of fatty acid synthesis?
Acetyl-CoA
What enzyme regulates fatty acid synthesis?
Acetyl-CoA carboxylase
What is the rate-limiting enzyme of cholesterol synthesis?
HMG-CoA reductase
What are lipoproteins?
Transport particles that carry lipids through the bloodstream
What is the function of VLDL?
Transports triglycerides made in the liver
Why is LDL called "bad cholesterol"?
It delivers cholesterol to cells and increases heart disease risk
Why is HDL called "good cholesterol"?
It removes cholesterol from cells and returns it to the liver