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what is an electrophile?
an e- deficient molecule w/ a +ve/δ+ charge attracted to e- rich regions in other molecules/ions
give the equation for the nitration of benzene:
outline the mechanism for the nitration of benzene:
which catalyst is used in the nitration of benzene? what is the significance of this?
sulfuric acid (H2SO4)
helps to make the nitronium ion - NO2+
give the 2 eqns for the formation of the nitronium ion:
HNO3 + H2SO4 → H2NO3+ + HSO4-
H2NO3+ → H2O + NO2+
give 2 reasons why the nitration step is important in organic synthesis:
used in the manufacture of explosives
used in the formation of amines
outline the steps of Friedel-Crafts acylation in eqn/mechanism form: