1) Blood coagulates to form a blood clot through a complex series of steps involving all of the following substances, EXCEPT ________. A) clotting factors B) platelets C) white blood cells D) thromboplastin
D) thromboplastin
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2) Warfarin (Coumadin, Jantoven) is ________. A) measured in milligrams B) given orally C) given intravenously D) all of the above
D) all of the above
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3) ________ drugs bind to fibrin strands in the clot, convert plasminogen in the clot to plasmin (fibrinolysin), an enzyme that breaks apart fibrin and the clot. A) Anticoagulant B) Platelet aggregation inhibitor C) Factor Xa inhibitor D) Thrombolytic
D) Thrombolytic
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6) Heparin is always measured in ________. A) grains B) milligrams C) milliliters D) units
D) units
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9) One cause of anemia is due to a decrease in the ________ in the blood. A) amount of vitamin K B) number of clotting factors C) number of red blood cells D) volume of blood
C) number of red blood cells
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10) Anticoagulant drugs are used to ________ a blood clot. A) dissolve B) enhance C) prevent D) treat
C) prevent
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12) The platelet aggregation inhibitor drug dipyridamole (Persantine) is given along with other anticoagulant drugs to preventing platelets from ________. A) adhering to artificial heart valves B) forming blood clots after a myocardial infarction C) causing anemia D) inhibiting vitamin K
A) adhering to artificial heart valves
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13) Cathflo Activase is used to ________. A) break up a clot that has formed in a urinary catheter B) break up a clot that has formed in a central venous catheter or intravenous line C) prevent a clot from forming in a central line D) to do hemodialysis
B) break up a clot that has formed in a central venous catheter or intravenous line
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14) Tissue plasminogen activator (tPA) drugs are given at the time of a ________ to dissolve a blood clot that has already formed. A) myocardial infarction B) stroke C) pulmonary embolism D) all of the above
all of the above
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18) Hemophiliac patients are given ________. A) units of whole blood B) blood products (plasma, packed red blood cells) C) clotting factors D) all of the above
all of the above
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21) The ending ________ is common to generic name heparin and low molecular weight heparin drugs. A) -rudin B) -parin C) -ase D) all of the above
B) -parin
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22) Hemophilia A is ________. A) the most common type of hemophilia B) caused by a lack of folic acid to build red blood cells C) caused by the lack of clotting factor VIII D) A and C
A and C
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26) All of the following are thrombin inhibitor drugs, EXCEPT ________. A) apixaban (Eliquis) B) bivalirudin (Angiomax) C) desirudin (Ipravask) D) lepirudin (Refludan)
A) apixaban (Eliquis)
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27) Which of the following is true of phytonadione (Mephyton)? A) It is a vitamin K drug. B) It is used to treat patients with an overdose of anticoagulant drug. C) It is used to prevent hemorrhagic disease of the newborn. D) all of the above
D) all of the above
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30) Which of the following is an example of the drug effect of antagonism? A) changing from intravenous heparin in the hospital to an oral anticoagulant drug upon discharge home B) giving a vitamin K drug to a newborn after birth to prevent hemorrhagic disease C) taking an anticoagulant drug with a meal of leafy green vegetables D) all of the above
C) taking an anticoagulant drug with a meal of leafy green vegetables
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31) A platelet aggregation inhibitor drug would be given in all of the following situations, EXCEPT ________. A) to prevent hemorrhagic disease after a newborn's birth B) to prevent a blood clot after a myocardial infarction or stroke C) to prevent a blood clot during angioplasty or cardiac valve surgery D) to treat patients with acute coronary syndrome
A) to prevent hemorrhagic disease after a newborn's birth
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32) In the drugs ferrous fumarate (Ferro-Sequels and ferrous gluconate (Fergon), the word ferrous tells you that these drugs contain ________. A) folic acid B) iron C) thrombin D) erythropoietin
B) iron
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35) Besides being an antiplatelet drug, aspirin has other effects that include ________. A) relieving pain B) reducing fever C) reducing inflammation D) all of the above
all of the above
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The liver produces clotting factors I through VIII.
False
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Heparin can only be given subcutaneously or intravenously.
True
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Thrombin inhibitor drugs bind to receptors on both circulating thrombin and thrombin already incorporated in a blood clot.
True
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Hemophilia is an inherited genetic abnormality that causes a deficiency of a specific clotting factor.
True
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Darbepoetin alfa, epoetin alfa, and epoetin beta are erythropoietin-like drugs created with recombinant DNA technology.
True
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A saline or heparin lock is a device that provides immediate intravenous access for administering intravenous drugs without the need to have intravenous fluids running continuously.
True
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Factor Xa inhibitor drugs are used to prevent blood clots in patients undergoing joint replacement surgery or abdominal surgery.
True
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Aspirin prolongs the clotting time by inhibiting thromboxane, a substance in the blood that causes platelet aggregation.
True
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clopidogrel (Plavix)
Platelet aggregation inhibitor drug
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ferrous sulfate
Over-the-counter iron supplement
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Aggrenox
Combination aspirin and platelet aggregation inhibitor drug
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