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embryonic pd
first 8 weeks of dev/gestation
pd where all major differentiation occurs!
development of systems
when do malformations occur
aberrations during the embryonic pd
in nervous sys and/or msk sys
major neurological events in embryonic pd
formation of neural tube and prosencephalon
when does general formation occur
during the embryonic pd
fetal pd
9 weeks to birth
growth and maturation of organ sys
when do deformities occur
if there are aberrations in the fetal pd
deformities of the msk sys
ex of deformation vs malformation
deformation- head shape, club foot, etc
malformation- neural tube doesn't close
what can we do as PTs for malformations vs deformations
we can't change malformations, but could help deal with muscle imbalances that are a result of the malformation
for deformations, we can attempt to correct the forces of the deformation
axial skeleton
vertebral column and ribs
what induces axial skeleton dev
induced by notochord (sends out message to start dev)
what are the three major things that need to happen in axillary dev
closure of neural tube, bones close around that, resegmentation
how does the axial skeleton dev
paraxial mesoderm
thickens either side of notochord, arranges into somites, somites divide
what do somites divide into
sclerotome -> vertebral column and ribs
dermamyotome -> myotome (skeletal mm) and dermotome (dermis/subcutaneous fascia)
what induces appendicular skeleton dev
induced by apical ectodermal ridge (signals limbs to start growing
why is selective cell death important in dev of the appendicular skeleton
needed for the hands! selective cell death allows space between fingers rather than all being connected
appendicular skeleton
pelvic and pectoral girdles and extremities
how does the appendicular skeleton dev
lateral plate mesoderm migrates out to limb buds
when do limb buds appear
at 4th week
after limb buds appear, what happens
initially project out, bend ant at elbows and knees, UE rot ext and LE rot int=anatomical pos
apical ectodermal ridge
induces appendicular skeleton dev
neural tube closure
dev of CNS in within first 8 weeks
has to close, bone close around that, and skin close around bone ->full closure in order to form spinal cord
if neural tube doesn't close what happens
could cause spina bifida, or if bone doesn't close = back pain
sclerotomic resegmentation
spine has to resegment (bones change)
each half came from dif somites so muscles can go from one vertebrae to another
interzone (during jt dev)
in precartilaginous stage, mesenchyme at sites where future joints will be thins out/becomes less dense
genetically determined
after interzone, what happens in joint formation
primitive joint capsules dev, intra articular structures appear (ex- menisci), then cavitation begins jt cavity formation
cavitation begins as a __________ process that appears to be independent of joint activity
enzymatic
after synovial cavity est during 3rd month, what is essential for normal dev of synovial joints
movement! if not moving in utero after 3rd month, atypical jt dev
muscle dev from ______
mesoderm
when do mesenchymal cells modulate into myoblasts
about 4 weeks
myoblasts aggregate into ________
syncycial tubes
when do primitive mm fibers appear
abou 5 weeks
grow in length by incorporating additional myoblasts
at 7 weeks of mm dev, what happens
fibers have become contractile but motor end plates not yet est
when does the motor end plate get est
about 10 weeks
muscle differentiation proceeds _____ to ______
proximal to distal
general overview of muscle dev
stem cells make myoblasts which proliferate, line up and connect to make a mm fiber and then a whole mm
major events in neural dev
neural proliferation and generation of glial cells, neural migration, organization, and myelination
neural proliferation
making neurons that will be in brain
in ventricular zone
neural migration
follow glial cells
get to where they're supposed to be in the brain
organization of neural dev
once they're where they need to be, organize in correct arrangement (crate synapses, form dendrites, layers of the brain, etc)
myelination of neural dev
birth to postnatal
myelin sheath formation to increase speed of nerve transmission
primitive reflexes
type of automatic movement that are present at birth and fade over time
primitive reflex generalizations
present in all infants at certain ages, age range for when each reflex exists, emergence and fading of reflexes is gradual, many primitive reflexes are present in utero and integrated around 4-6 months, can be elicited in normal indiv with sufficient stress, can be tested with a stim/response, elicited actively or passively, never normally obligatory, under neural control but induced by environmental factors, have funct/clinical significance, can be observed functionally or in terms of when they come spontaneously
asymmetrical tonic neck reflex
when turn head one way, ipsilateral arm ext and other bends
if sticks around too long, can't get head to mouth
symmetrical tonic neck reflex
if ext neck, elbows ext and legs flex/vice versa (arms mimc head)
gets in the way of crawling if doesn't go away
tonic labyrinthine reflex
if lying on back, makes you ext more and if lying on stomach, makes you flex more
grasp reflexes
if you put something in their palm, hand will close around it
if sticks around too long, makes it difficult to use hands functionally
plantar grasp reflex
in feet, if stim PIP joint/toes, toes close
inhibits balance if doesn't go away
positive support reaction
if stand baby on feet, stiffen their legs to support their weight (go up on toes)
stepping reflex
hold baby up in standing and tilt them slightly fwd, start taking rhythmical steps
if doesn't go away can make it difficult to walk
suck and swallow reflex
in you put your finger in their mouth, will suck/swallow regularly (important to prevent aspiration)
can affect speech if doesn't go away
rooting reflex
touch corner of mouth, lips deviate to that side (helps find nipple)
affects speech if sticks around too long
galant reflex
when hold baby up and touch their side, flex trunk towards taht side
contr to scoliosis if sticks around too long
crossed ext reflex
if step on something sharp and hold their, other leg comes across leg
moro reflex
if head rops, hands come out then back in together
allows them to grab onto something if falling
when should primitive reflexes go away
around 4-6 months
when is ATNR really strong
at 2 months
how are reactions different than reflexes
reactions can habituate, evolve, and dev over time
righting reactions
automatic movements that serve to maintain and restore vertical pos of head in space and alignment of head/trunk and trunk/limbs (aka keeping head neck and trunk at midline)
equilibrium reactions
serve to maintain and regain balance during movement
not born with! dev over time as primitive reflexes fade
order of equilibrium reactions
1- elongation of wt bearing side
2- flex of non wt bearing side
3- limb counter balancing towards non wt bearing side
4- rotate to reach farther to non wt bearing side
5- if none of the above work, staggering/protective rxns (put hands out or step so you don't fall)
fetal movement before 10 weeks, at 10 weeks, and by 15 weeks
before 10 weeks- movement is wormlike, not org in patterns
at 10 weeks- neurally driven movement begins
by 15 weeks- almost all movement present
what is the order of movements acquired
ext first, then flex, lat flex, and lastly rotation
a one month old will be in _________ and by 2 months will _________
physiological flexion
stretch out into extension
when is a baby strong in their flexors and can get hands/feet up against gravity
at 3 months
when can babies hold their head in the middle, hold hands tg at midline, and have knees/legs up in the air at the same time (all in supine)
by 4 months
when do babies reach full anitgravity flexion (hands to feet)
6 months
when do babies reach full antigravity in prone (swimming)
6 months
3 key things that happen at the hip during dev
retroversion/anteversion
dev of head and neck of femur
angle of inclination
dev of head and neck of femur
at 1st, only 1 growth plate, but then genetic message sends to growth plate to grow and form a second plate
angle of inclination of femur
larger angle at first=femur starts out more straight
eventually becomes more acute due to gravity/forces pushing down on it
anteversion/retroversion of the femur
distal femur is what rotates, not the head/neck!
1st in utero=retroverted, then int rot and are in excessive anteversion when born, then during childhood become less anteverted/normal amount
effects of too much or not enough anteversion
too much anteversion=toe in
too mcuh retroversion=toe out
important dev at the knee
varus (bc stand with ft wide aprt)->valgus (bc ft wide apart, line of gravity inwards causing valgus around 3 yrs)->less valgus (around 6 yrs)
what can result from the hip not dev properly
hip subluxation
foot and ankle important dev
dev of the arch
how does dev of the arch happen
flat footed when first stand bc line of gravity inwards and arch collapses bc no bony contours yet, no foot pad under foot, smooth cartilage, and fib/tib are same length
limb dissociation vs intersegmental dissociation vs intralimb dissociation
moving limbs vs moving limbs separate from each other (one leg ext, other is flex) vs multiple actions of one limb (flex knee but ext foot)
stability vs mobility
stability needed to move well
mobility- too much or too little makes it hard to move well
what parameters can be used to measure growth
height, weight, proportion, head circumference, bone density, dentition (red flag if lose teeth before 6 yrs)
what's an important component of complex movement
weight shift
generalizations about equilibrium rxns
described in terms of response to perturbation, observed in any pos, perturbations to elicit rxns can vary, mechanism of imposition of perturbation varies
what directions are most commonly used in equilibrium rxns
med/lat, ant/post, diagonal
alberta infant motor skill
most observational
put them in pos and see waht they can do spontaneously
difference bw newborns and premature babies
premature babies don't get intrauterine constraint so move more
not in flex when born
what do you do in the NICU for premature babies
imitate their environ in utero- give them constraint by swaddling the,, damp down senses, give them time to sleep, cluster care
synactive theory for high risk infants
physiological stability-> motor organization -> behavioral state organization -> attention/interaction -> self regulation
walking at 2.5 years
kinematics same as an adult, but no heel strike or push off (heel strike around 3 yrs old)
when can kids ride a bike
3 yrs- tricycle, 5 yrs- training wheels, 6 yrs- no wheels
normal motor dev from 1-5 yrs
growth, dev, increased motor control, skill acquisition
2 pds of rapid growth in weight
3rd trimester and infancy
adolescence
2 pds of rapid growth in height
2nd trimester and infancy
adolescence
head circumference
at birth, circumference is 70% of adult size
essentially complete by age 10
muscle growth
greatest inc in number of fibers before birth
inc both number and size of fibers in 1st yr of life
after 1st yr growth primarily from inc fiber size
gait kinematics at 12-13 months (generally anywhere between 9-15 months)
kinematics are immature!
wide BOS, ant pelvic tilt/lordosis, dec trunk and pelvic rot, inc hip and knee flex, lack of armswing
visual perception
vision coming in
shows if eyes are working ok, optic nerve working, transmitting info to occipital cortex
visual cognition
making sense of what you're seeing
involves association cortices
initial hand use
first thing that happens in grasp reflex but not voluntary grasping
stages of grasping
move into finger flex by scratching surfaces, then grab with fist, then use ulnar side and lastly radial side (sophisticated grasp)
_______ is just as important as grasping!
reaching and releasing
when would you refer to an OT
difficulty with reaching, grasping, releasing (fine motor skills)
sensory processing issues
feeding and coordinating mm