Part 7: Plant Alkaloids

Plant Alkaloids aka

Vinca Alkaloids

Plant Alkaloids are cell cycle (specific/ non-specific)

specific

What cycle are plant alkaloids are specific to?

M phase

How do plant alkaloids kill cells?

Bind to microtubular proteins during metaphase → causing Mitotic Arrest

The cell cannot divide, and dies when making the attempt

What are the 6 plant alkaloid drugs?

1. vincristine (oncovin)

2. vinblastine (Velban)

3. VP-16 (Etoposide)

4. Vinorelbine (Navelbine)

5. Taxol (paclitaxol)

6. Taxotere (docetaxel)

Which plant alkaloid is synergistic with RTT?

taxol

What are the following drugs made from?

Taxol

vincristine

.VP-16

Vinblastine

Taxotere

How do vincristine and vinblastine cause cell kill?

inhibiting the mitotic spindle,

The cell doubles the chromosomes, but cell can’t divide cuz spindle wont separate

What are the following drugs used to treat?

Vincristine

Vinblastine

Vincristine (is out for blood)

1. Lymphoid CAs (HD & NHL)

2. Leukemia

3. Multiple Myeloma

Vinblastine (a blast of air and a blast of …)

1. lung CA

2. Testicular CA

What side effects do the following drugs have?

Vincristine

Vinblastine

Vincristine:

Peripheral neuropathy- numbness + tingling of fingers and toes

Vinblastine:

More BMS than vincristine, but less peripheral neuropathy

What is VP-16 used for?

• Some Lymphomas

• Testicular

• Small Cell Lung CA

(kinda like a combo of vincristine and vinblastine)

Side effects for VP-16?

BSM, very little of anything else

(the mandrake is really a man’s best friend)

What are the following drugs used for?

Taxol

Taxotere

1. Recurrent ovarian

2. Breast

3. Combined with carboplatin for Lung CA

Taxotere- a newer drug better than taxol & with less side effects - same uses

Toxicities for

Taxol

Taxotere

Taxol

1, Peripheral Neuropathy

2, BMS

3, Allergic Rxns

(same as vinblastine but also with allergic rxns)

Taxotere

neuropathy (but not as bad as taxol)

Due to Taxol causing allergic reactions, what interventions must we do for a patient allergic to it?

Premedicate them with Benadryl + steroids

How does Vinorelbine cause cell kill?

Affects mitotic spindle

What is vinorelbine used for?

lung + breast CAs