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Circadian Rhythm
The body’s biological clock; operates on a 24-hour cycle; regulates cycles of alertness and sleepiness
Ultradian Rhythm
90-minute sleep cycles; regulate sleep stages, oscillating between NREM and REM sleep; in consecutive cycles, N1 and N3 sleep shorten, while N2 and REM sleep lengthen.
Pre-NREM-1 Stage
Awake but relaxed; high frequency alpha waves
NREM Stage 1
characterized by theta brain waves; sensations from the environment filter into mental images/dreams; hypnagogic sensations—sensations of falling or floating and jerking awake
NREM Stage 2
Characterized by sleep spindles—rapid bursts of rhythmic brain wave activity; can be awakened w/o much difficulty, but clearly asleep
NREM Stage 3
Characterized by delta brain waves; deepest level of NREM sleep—lowest level of consciousness; tissue and cellular repair, strengthens immune system, growth hormone released; night terrors, sleepwalking, and sleeptalking occur in this stage
REM Sleep
Brain waves become rapid and saw-toothed; breathing heart rate, brain activity all increase, but body is paralyzed; characterized by rapid eye movement; most vivid dreams occur in REM; aids memory consolidation and learning
Suprachiasmatic Nucleus (SCN)
Pair of cell clusters in the hypothalamus that regulate circadian rhythm; adjusts melatonin production in response to light
Melatonin
A hormone that helps with the timing of the circadian rhythm; helps humans fall asleep and stay asleep
Insomnia
Sleep disorder characterized by difficulty falling and staying asleep; causes fatigue and increased risk of depression, obesity, hypertension, etc.
Narcolepsy
Sleep disorder characterized by sudden sleep attacks; fall directly into REM sleep; disrupts daily activities
Sleep Apnea
Sleep disorder characterized by stopped breathing during sleep; disrupts sleep and causes sleep deprivation; leads fatigue and increased risk of depression and obesity
Psychoactive Drug
A chemical substance that alters the brain, causing changes in perceptions and moods
Tolerance
When the brain and body adapt to offset the effects of a substance; requires a higher dose to feel the same effect
Withdrawal
Physical and psychological symptoms that occur after stopping intake of a drug
Physical: pain, headaches, nausea, vomiting, etc.
Psychological: guilt, depression, anxiety, desire to escape reality/lower self-awarness
Addiction
Physical and/or psychological dependence on a substance, causing disruptions of normal life activities
Stimulants
Drugs that excite neural activity and speed up body functions; heart rate, respiration, and body temp increase (similar to fight or flight response)
Depressants
Drugs that reduce neural activity and slow body functions; heart rate, respiration, and body temp decreases (similar to rest and digest response)
Hallucinogens
Psychedelic (“mind-manifesting”) drugs that distort perceptions and evoke sensory images in the absence of sensory input
Ecstasy (MDMA)
Stimulant and mild hallucinogen; causes serotonin transporters to pump serotonin into synapse, causing excess serotonin
Desirable effects: high energy, emotional elevation, connectedness with others
Negative effects: dehydration, permanently depressed mood (damage to serotonin-producing neurons), impaired cognitive and immune system functioning
Methamphetamine
Stimulant; causes dopamine transporters to pump dopamine into synapse, causing excess dopamine
Desirable effects: increased alertness and energy, euphoria
Negative effects: irritability, insomnia, hypertension, seizures
Cocaine
Stimulant; blocks reuptake, causing excess dopamine in the synapse
Desirable effects: rush of euphoria, increased energy and alertness
Negative effects: heightened reaction and aggression, cardiovascular stress, fidgeting, depressive crash
Alcohol
Depressant; increases the inhibitory effects of GABA and binds to glutamate receptors, preventing glutamate from binding
Desirable effects: rush of euphoria, disinhibition, relaxation, reduced self-consciousness
Negative effects: impaired decision making and motor function, slowed reactions, organ damage, impairs memory
Barbiturates
Depressants/tranquilizers; enhance the effects of GABA
Desirable effects: induce sleep, reduce anxiety
Negative effects: impairs memory and judgement
Opioids (e.g. Heroin)
Depressant; binds to opiate receptors, shutting down the release of inhibitory neurotransmitters and causing a flood of dopamine
Desirable effects: rush of euphoria, pain relief, stress relief
Negative effects: sedation, loss of natural endorphin production
Marijuana
Hallucinogen and mild depressant; binds to cannabinoid receptors, turning off the release of inhibitory neurotransmitters, causing a flood of dopamine
Desirable effects: disinhibition, relaxation, enhanced sensation, mild hallucinations
Negative effects: impaired learning and memory, impaired motor coordination and reaction time
LSD
Hallucinogen; mimics serotonin and binds to serotonin receptors; can be inhibitory or excitatory
Desirable effects: hallucinations
Negative effects: near-death experiences, panic